ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	UBC
Approved Name	ubiquitin C
Name Alias	polyubiquitin-C
Location	12q24.3
Position	chr12:125396192-125399577, -
External Links	HGNC: 12468 Entrez Gene: 7316 Ensembl: ENSG00000150991 UCSC: uc001ugs.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_26	chr12:122465458-124605386 (NCBI36 / hg18)	2139929	12q24.31-12q24.32	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 76)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 76)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045087	innate immune response	Biological Process		54
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0042981	regulation of apoptotic process	Biological Process		32
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process		27
GO:0050852	T cell receptor signaling pathway	Biological Process		21
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process		27
GO:0046788	egress of virus within host cell	Biological Process		4
GO:0048011	nerve growth factor receptor signaling pathway	Biological Process		42
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		12
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		12
GO:0051403	stress-activated MAPK cascade	Biological Process		10
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		10
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	Biological Process		3
GO:0071456	cellular response to hypoxia	Biological Process		12
GO:0060613	fat pad development	Biological Process		2
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	Biological Process		5
GO:0097009	energy homeostasis	Biological Process		1
GO:0072520	seminiferous tubule development	Biological Process		1
GO:0007173	epidermal growth factor receptor signaling pathway	Biological Process		25
GO:0007179	transforming growth factor beta receptor signaling pathway	Biological Process		14
GO:0007219	Notch signaling pathway	Biological Process		21
GO:0007220	Notch receptor processing	Biological Process		2
GO:0007249	I-kappaB kinase/NF-kappaB cascade	Biological Process		5
GO:0007254	JNK cascade	Biological Process		11
GO:0008063	Toll signaling pathway	Biological Process		11
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process		26
GO:0008585	female gonad development	Biological Process		3
GO:0010008	endosome membrane	Cellular Component		27
GO:0010467	gene expression	Biological Process		140
GO:0010992	ubiquitin homeostasis	Biological Process		1
GO:0016032	viral reproduction	Biological Process		57
GO:0016044	cellular membrane organization	Biological Process		24
GO:0016070	RNA metabolic process	Biological Process		46
GO:0016071	mRNA metabolic process	Biological Process		34
GO:0019221	cytokine-mediated signaling pathway	Biological Process		28
GO:0016197	endosomal transport	Biological Process		11
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Biological Process		13
GO:0021888	hypothalamus gonadotrophin-releasing hormone neuron development	Biological Process		1
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process		14
GO:0030666	endocytic vesicle membrane	Cellular Component		11
GO:0033554	cellular response to stress	Biological Process		12
GO:0032480	negative regulation of type I interferon production	Biological Process		10
GO:0034134	toll-like receptor 2 signaling pathway	Biological Process		10
GO:0034130	toll-like receptor 1 signaling pathway	Biological Process		10
GO:0034142	toll-like receptor 4 signaling pathway	Biological Process		11
GO:0034138	toll-like receptor 3 signaling pathway	Biological Process		11
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	Biological Process		8
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	Biological Process		10
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	Biological Process		14
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	Biological Process		6
GO:0000075	cell cycle checkpoint	Biological Process		21
GO:0000080	G1 phase of mitotic cell cycle	Biological Process		6
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0002020	protease binding	Molecular Function		13
GO:0000209	protein polyubiquitination	Biological Process		23
GO:0000216	M/G1 transition of mitotic cell cycle	Biological Process		13
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0000187	activation of MAPK activity	Biological Process		21
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process		26
GO:0000084	S phase of mitotic cell cycle	Biological Process		20
GO:0005829	cytosol	Cellular Component		447
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005515	protein binding	Molecular Function	IPI[19285159]	910
GO:0002756	MyD88-independent toll-like receptor signaling pathway	Biological Process		9
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Biological Process		10
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	Biological Process		14
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Biological Process		17
GO:0002224	toll-like receptor signaling pathway	Biological Process		10
GO:0007144	female meiosis I	Biological Process		2
GO:0007141	male meiosis I	Biological Process		3
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Biological Process		11
GO:0006915	apoptotic process	Biological Process		111
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process		42
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0006281	DNA repair	Biological Process		62
GO:0005886	plasma membrane	Cellular Component		772

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03320	PPAR signaling pathway	12	Peroxisome proliferator-activated receptors (PPARs) are nucl...... Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. More...

Genes shared at least 5 GO terms with UBC (count: 153)

Gene Symbol	Pathway Count	Pathway List
UBB	67	innate immune response; positive regulation of transcription from RNA polymerase II promoter; regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; T cell receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; egress of virus within host cell; nerve growth factor receptor signaling pathway; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; stress-activated MAPK cascade; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleotide-binding oligomerization domain containing signaling pathway; cellular response to hypoxia; regulation of transcription from RNA polymerase II promoter in response to hypoxia; epidermal growth factor receptor signaling pathway; transforming growth factor beta receptor signaling pathway; Notch signaling pathway; Notch receptor processing; I-kappaB kinase/NF-kappaB cascade; JNK cascade; Toll signaling pathway; fibroblast growth factor receptor signaling pathway; endosome membrane; gene expression; viral reproduction; cellular membrane organization; RNA metabolic process; mRNA metabolic process; cytokine-mediated signaling pathway; endosomal transport; negative regulation of transforming growth factor beta receptor signaling pathway; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; endocytic vesicle membrane; cellular response to stress; negative regulation of type I interferon production; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I; negative regulation of epidermal growth factor receptor signaling pathway; cell cycle checkpoint; G1 phase of mitotic cell cycle; mitotic cell cycle; protein polyubiquitination; M/G1 transition of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; activation of MAPK activity; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cytosol; nucleoplasm; protein binding; MyD88-independent toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; toll-like receptor signaling pathway; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; DNA repair; plasma membrane;
PSMB7	23	regulation of apoptotic process; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cell cycle checkpoint; mitotic cell cycle; protein polyubiquitination; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cytosol; nucleoplasm; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process;
PSMC3	23	regulation of apoptotic process; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cell cycle checkpoint; mitotic cell cycle; protein polyubiquitination; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cytosol; nucleoplasm; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process;
PSMD5	23	regulation of apoptotic process; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cell cycle checkpoint; mitotic cell cycle; protein polyubiquitination; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cytosol; nucleoplasm; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process;
PSMD7	23	regulation of apoptotic process; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cell cycle checkpoint; mitotic cell cycle; protein polyubiquitination; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cytosol; nucleoplasm; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process;
MAPK3	22	innate immune response; positive regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; stress-activated MAPK cascade; epidermal growth factor receptor signaling pathway; Toll signaling pathway; fibroblast growth factor receptor signaling pathway; gene expression; cytokine-mediated signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; activation of MAPK activity; cytosol; nucleoplasm; protein binding; MyD88-independent toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; apoptotic process;
PSME1	22	regulation of apoptotic process; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cell cycle checkpoint; mitotic cell cycle; protein polyubiquitination; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cytosol; nucleoplasm; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process;
PSME2	22	regulation of apoptotic process; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cell cycle checkpoint; mitotic cell cycle; protein polyubiquitination; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cytosol; nucleoplasm; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process;
MAPK1	21	innate immune response; T cell receptor signaling pathway; nerve growth factor receptor signaling pathway; stress-activated MAPK cascade; epidermal growth factor receptor signaling pathway; Toll signaling pathway; fibroblast growth factor receptor signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; activation of MAPK activity; cytosol; nucleoplasm; protein binding; MyD88-independent toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; apoptotic process; transcription, DNA-dependent;
RELA	19	innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; T cell receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; nerve growth factor receptor signaling pathway; Toll signaling pathway; cytokine-mediated signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; cytosol; nucleoplasm; protein binding; MyD88-independent toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway;
PSMA8	19	regulation of apoptotic process; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cell cycle checkpoint; mitotic cell cycle; protein polyubiquitination; M/G1 transition of mitotic cell cycle; S phase of mitotic cell cycle; cytosol; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process;
MAPK7	17	innate immune response; positive regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; stress-activated MAPK cascade; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; cytosol; nucleoplasm; protein binding; MyD88-independent toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; apoptotic process;
TLR4	17	innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; I-kappaB kinase/NF-kappaB cascade; Toll signaling pathway; endosome membrane; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; activation of MAPK activity; protein binding; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; plasma membrane;
MAP2K3	15	innate immune response; stress-activated MAPK cascade; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; activation of MAPK activity; cytosol; nucleoplasm; protein binding; MyD88-independent toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway;
MAPK9	15	innate immune response; stress-activated MAPK cascade; JNK cascade; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; cytosol; nucleoplasm; protein binding; MyD88-independent toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway;
IRF7	13	innate immune response; positive regulation of transcription from RNA polymerase II promoter; Toll signaling pathway; endosome membrane; cytokine-mediated signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; cytosol; nucleoplasm; protein binding; MyD88-independent toll-like receptor signaling pathway;
TIRAP	12	innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; I-kappaB kinase/NF-kappaB cascade; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 4 signaling pathway; protein binding; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; plasma membrane;
XPO1	11	transforming growth factor beta receptor signaling pathway; gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; cytosol; nucleoplasm; protein binding;
MEN1	10	positive regulation of transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; gene expression; negative regulation of transcription from RNA polymerase II promoter; cytosol; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; DNA repair;
MALT1	9	innate immune response; regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; T cell receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; protease binding; cytosol; protein binding; plasma membrane;
E2F5	9	positive regulation of transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; gene expression; G1 phase of mitotic cell cycle; mitotic cell cycle; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent;
CDC26	9	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell cycle checkpoint; mitotic cell cycle; cytosol; nucleoplasm; protein binding;
NEDD4L	9	transforming growth factor beta receptor signaling pathway; gene expression; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; cytosol; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent;
SKP2	9	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; G1 phase of mitotic cell cycle; mitotic cell cycle; protein polyubiquitination; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cytosol; nucleoplasm; protein binding;
PRKD1	8	innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; cytosol; protein binding; apoptotic process; plasma membrane;
PIK3R1	8	positive regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; nerve growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cytosol; protein binding; plasma membrane;
BAD	8	nerve growth factor receptor signaling pathway; cellular response to hypoxia; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cytokine-mediated signaling pathway; cytosol; protein binding; apoptotic process;
ANAPC4	8	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell cycle checkpoint; mitotic cell cycle; cytosol; nucleoplasm;
PLK1	8	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; cytosol; nucleoplasm; protein binding;
TCEB1	8	cellular response to hypoxia; regulation of transcription from RNA polymerase II promoter in response to hypoxia; gene expression; viral reproduction; cellular response to stress; cytosol; nucleoplasm; protein binding;
NCOR1	8	transforming growth factor beta receptor signaling pathway; Notch signaling pathway; gene expression; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent;
NCOR2	8	transforming growth factor beta receptor signaling pathway; Notch signaling pathway; gene expression; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent;
HSPA8	8	gene expression; cellular membrane organization; RNA metabolic process; mRNA metabolic process; cytosol; protein binding; transcription, DNA-dependent; plasma membrane;
FADD	7	innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; protease binding; cytosol; protein binding; apoptotic process;
TNFAIP3	7	innate immune response; nucleotide-binding oligomerization domain containing signaling pathway; negative regulation of type I interferon production; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; protease binding; cytosol; protein binding;
TXN	7	innate immune response; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; cytosol; nucleoplasm; protein binding; transcription, DNA-dependent;
GSK3B	7	positive regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cytosol; protein binding; plasma membrane;
NR4A2	7	positive regulation of transcription from RNA polymerase II promoter; gene expression; cellular response to stress; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent;
RBPJ	7	positive regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; gene expression; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
SNW1	7	positive regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; gene expression; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
SQSTM1	7	positive regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; endosomal transport; cytosol; nucleoplasm; protein binding; apoptotic process;
BCAR1	7	regulation of apoptotic process; T cell receptor signaling pathway; nerve growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; cytosol; protein binding; plasma membrane;
PRKCB	7	positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; cytosol; protein binding; apoptotic process; transcription, DNA-dependent; plasma membrane;
EGLN3	7	cellular response to hypoxia; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to stress; cytosol; nucleoplasm; protein binding; apoptotic process;
NCBP1	7	gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; cytosol; nucleoplasm; protein binding;
RQCD1	7	gene expression; RNA metabolic process; mRNA metabolic process; cytokine-mediated signaling pathway; cytosol; protein binding; transcription, DNA-dependent;
CDC45	7	cell cycle checkpoint; mitotic cell cycle; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; nucleoplasm; protein binding;
CCND1	7	G1 phase of mitotic cell cycle; mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cytosol; nucleoplasm; protein binding;
CDT1	7	mitotic cell cycle; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cytosol; nucleoplasm; protein binding;
CASP1	6	innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; cytosol; protein binding; apoptotic process;
NCF2	6	innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; cytosol; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I;
RIPK3	6	innate immune response; positive regulation of NF-kappaB transcription factor activity; I-kappaB kinase/NF-kappaB cascade; cytosol; protein binding; plasma membrane;
ARRB1	6	positive regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; cellular membrane organization; cytosol; protein binding; plasma membrane;
GATA6	6	positive regulation of transcription from RNA polymerase II promoter; cellular response to hypoxia; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; apoptotic process;
MAML1	6	positive regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; gene expression; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
MED1	6	positive regulation of transcription from RNA polymerase II promoter; gene expression; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
VEGFA	6	positive regulation of transcription from RNA polymerase II promoter; cellular response to hypoxia; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to stress; negative regulation of transcription from RNA polymerase II promoter; protein binding;
YAP1	6	positive regulation of transcription from RNA polymerase II promoter; gene expression; cytosol; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
TGFBR1	6	regulation of apoptotic process; transforming growth factor beta receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; protein binding; apoptotic process; plasma membrane;
BIRC2	6	positive regulation of I-kappaB kinase/NF-kappaB cascade; protein polyubiquitination; cytosol; protein binding; apoptotic process; transcription, DNA-dependent;
PAK1	6	T cell receptor signaling pathway; cellular response to stress; cytosol; protein binding; apoptotic process; plasma membrane;
ADRBK1	6	nerve growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cytosol; protein binding; plasma membrane;
PRKAR2B	6	nerve growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; mitotic cell cycle; cytosol; plasma membrane;
CBL	6	epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; cytosol; protein binding; plasma membrane;
CNOT6	6	gene expression; RNA metabolic process; mRNA metabolic process; cytosol; protein binding; transcription, DNA-dependent;
POLR2G	6	gene expression; viral reproduction; nucleoplasm; apoptotic process; transcription initiation from RNA polymerase II promoter; DNA repair;
RPL13	6	gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; cytosol; protein binding;
RPL14	6	gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; cytosol; protein binding;
RPS3	6	gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; cytosol; protein binding;
RPS9	6	gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; cytosol; protein binding;
SMC1A	6	gene expression; cell cycle checkpoint; mitotic cell cycle; nucleoplasm; protein binding; DNA repair;
SMG1	6	gene expression; RNA metabolic process; mRNA metabolic process; cytosol; protein binding; DNA repair;
CAMK2D	6	cytokine-mediated signaling pathway; endocytic vesicle membrane; G1/S transition of mitotic cell cycle; cytosol; nucleoplasm; plasma membrane;
POLE	6	mitotic cell cycle; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; nucleoplasm; DNA repair;
CYBA	5	innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I;
HERC5	5	innate immune response; cytokine-mediated signaling pathway; negative regulation of type I interferon production; cytosol; protein binding;
MAVS	5	innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of type I interferon production; protein binding;
PYCARD	5	innate immune response; positive regulation of NF-kappaB transcription factor activity; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; cytosol; protein binding;
TAX1BP1	5	innate immune response; negative regulation of type I interferon production; cytosol; protein binding; apoptotic process;
UBE2L6	5	innate immune response; cytokine-mediated signaling pathway; negative regulation of type I interferon production; cytosol; protein binding;
ESRRA	5	positive regulation of transcription from RNA polymerase II promoter; gene expression; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
KAT5	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; cytosol; protein binding; transcription, DNA-dependent;
KDM1A	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; transcription, DNA-dependent;
MAML2	5	positive regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; gene expression; nucleoplasm; transcription initiation from RNA polymerase II promoter;
MCF2L	5	positive regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; cytosol; apoptotic process; plasma membrane;
MYB	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; G1/S transition of mitotic cell cycle; protein binding; transcription, DNA-dependent;
NCK1	5	positive regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; cytosol; protein binding; plasma membrane;
NCOA6	5	positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter; DNA repair;
NR5A1	5	positive regulation of transcription from RNA polymerase II promoter; gene expression; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
RORA	5	positive regulation of transcription from RNA polymerase II promoter; gene expression; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
STRN3	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; plasma membrane;
WWOX	5	positive regulation of transcription from RNA polymerase II promoter; cytosol; protein binding; apoptotic process; plasma membrane;
RTN4	5	regulation of apoptotic process; nerve growth factor receptor signaling pathway; protein binding; apoptotic process; plasma membrane;
TRAF1	5	regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; protein binding; apoptotic process;
EEF1D	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; gene expression; cytosol; protein binding; transcription, DNA-dependent;
GJA1	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; cellular membrane organization; protein binding; apoptotic process; plasma membrane;
NUP62	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; cytokine-mediated signaling pathway; protein binding; transcription, DNA-dependent;
RNF31	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; T cell receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; protein polyubiquitination; protein binding;
TERF2IP	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; nucleoplasm; protein binding; transcription, DNA-dependent;
ARHGEF2	5	positive regulation of NF-kappaB transcription factor activity; nerve growth factor receptor signaling pathway; cytosol; protein binding; apoptotic process;
VPS37C	5	egress of virus within host cell; endosome membrane; viral reproduction; cellular membrane organization; endosomal transport;
VPS37D	5	egress of virus within host cell; endosome membrane; viral reproduction; cellular membrane organization; endosomal transport;
ADAM17	5	nerve growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; Notch signaling pathway; protein binding; plasma membrane;
ADCY4	5	nerve growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; protein binding; plasma membrane;
FURIN	5	nerve growth factor receptor signaling pathway; transforming growth factor beta receptor signaling pathway; Notch signaling pathway; protease binding; plasma membrane;
MAPKAP1	5	nerve growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cytosol; plasma membrane;
RICTOR	5	nerve growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cytosol; protein binding;
PRKAA1	5	cellular response to hypoxia; activation of MAPK activity; cytosol; protein binding; transcription, DNA-dependent;
ERBB2	5	epidermal growth factor receptor signaling pathway; endosome membrane; protein binding; transcription, DNA-dependent; plasma membrane;
PLCE1	5	epidermal growth factor receptor signaling pathway; activation of MAPK activity; cytosol; protein binding; plasma membrane;
ARRB2	5	transforming growth factor beta receptor signaling pathway; Notch signaling pathway; cytosol; protein binding; plasma membrane;
CTGF	5	fibroblast growth factor receptor signaling pathway; gene expression; cytosol; transcription initiation from RNA polymerase II promoter; plasma membrane;
CLNS1A	5	gene expression; RNA metabolic process; cytosol; protein binding; plasma membrane;
DCPS	5	gene expression; RNA metabolic process; mRNA metabolic process; cytosol; protein binding;
DDX6	5	gene expression; RNA metabolic process; mRNA metabolic process; cytosol; protein binding;
FAU	5	gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; cytosol;
GTF2H3	5	gene expression; viral reproduction; nucleoplasm; transcription initiation from RNA polymerase II promoter; DNA repair;
LSM4	5	gene expression; RNA metabolic process; mRNA metabolic process; cytosol; protein binding;
PATL1	5	gene expression; RNA metabolic process; mRNA metabolic process; cytosol; protein binding;
RAN	5	gene expression; viral reproduction; cytosol; nucleoplasm; protein binding;
RPL12	5	gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; cytosol;
RPL35	5	gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; cytosol;
RPL37	5	gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; cytosol;
RPL37A	5	gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; cytosol;
RPL38	5	gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; cytosol;
RPS12	5	gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; cytosol;
RPS15A	5	gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; cytosol;
RPS25	5	gene expression; viral reproduction; RNA metabolic process; mRNA metabolic process; cytosol;
SEC61B	5	gene expression; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I;
SMG7	5	gene expression; RNA metabolic process; mRNA metabolic process; cytosol; protein binding;
SNRPB	5	gene expression; RNA metabolic process; cytosol; nucleoplasm; protein binding;
SNRPD1	5	gene expression; RNA metabolic process; cytosol; nucleoplasm; protein binding;
SNRPD2	5	gene expression; RNA metabolic process; cytosol; nucleoplasm; protein binding;
SNRPD3	5	gene expression; RNA metabolic process; cytosol; nucleoplasm; protein binding;
SNRPG	5	gene expression; RNA metabolic process; cytosol; nucleoplasm; protein binding;
SSRP1	5	gene expression; viral reproduction; nucleoplasm; protein binding; DNA repair;
TAF10	5	gene expression; viral reproduction; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
TAF13	5	gene expression; viral reproduction; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
CUL5	5	viral reproduction; G1/S transition of mitotic cell cycle; cytosol; protein binding; plasma membrane;
HMGA1	5	viral reproduction; cytosol; nucleoplasm; protein binding; transcription, DNA-dependent;
XRCC5	5	viral reproduction; nucleoplasm; protein binding; transcription, DNA-dependent; DNA repair;
PTTG1	5	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle; cytosol; protein binding; DNA repair;
WASL	5	endocytic vesicle membrane; cytosol; protein binding; transcription, DNA-dependent; plasma membrane;
ATM	5	cell cycle checkpoint; nucleoplasm; protein binding; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA repair;
CHEK1	5	cell cycle checkpoint; cytosol; nucleoplasm; protein binding; DNA repair;
RBBP8	5	cell cycle checkpoint; negative regulation of transcription from RNA polymerase II promoter; G1/S transition of mitotic cell cycle; protein binding; DNA repair;
RFWD2	5	cell cycle checkpoint; cytosol; nucleoplasm; protein binding; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
FEN1	5	mitotic cell cycle; S phase of mitotic cell cycle; nucleoplasm; protein binding; DNA repair;
POLA2	5	mitotic cell cycle; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; nucleoplasm;
POLD3	5	mitotic cell cycle; S phase of mitotic cell cycle; nucleoplasm; protein binding; DNA repair;
POLD4	5	mitotic cell cycle; S phase of mitotic cell cycle; nucleoplasm; protein binding; DNA repair;
RRM2	5	mitotic cell cycle; G1/S transition of mitotic cell cycle; cytosol; nucleoplasm; protein binding;
HINFP	5	G1/S transition of mitotic cell cycle; nucleoplasm; protein binding; transcription, DNA-dependent; DNA repair;

Genes shared at least 2 KEGG pathways with UBC (count: 0)

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Region: chr12:125396192..125399577 View in gBrowse