ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0048011
Name nerve growth factor receptor signaling pathway
Type biological process
No. of Genes in ADHDgene  51
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 51)

Literature-origin genes (count: 9)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
MAP2K5 mitogen-activated protein kinase kinase 5 15q22.31 1(1/0/0) TAS
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 9q22.1 1(1/0/0) TAS
TIAM2 T-cell lymphoma invasion and metastasis 2 6q25 1(0/0/1) TAS
TRIO trio Rho guanine nucleotide exchange factor 5p14-p15.1 1(0/0/1) TAS
ADRBK1 adrenergic, beta, receptor kinase 1 11q13 1(0/1/0) TAS
NGF nerve growth factor (beta polypeptide) 1p13.1 2(2/0/0) TAS
FURIN furin (paired basic amino acid cleaving enzyme) 15q26.1 1(0/0/1) TAS
NET1 neuroepithelial cell transforming 1 10p15 1(1/0/0) TAS
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0) TAS

Genes from other sources Help (count: 42)

Approved Symbol Approved Name Source Evidence[PMID]
MCF2L MCF.2 cell line derived transforming sequence-like Mapped by CNV TAS
AATF apoptosis antagonizing transcription factor Mapped by CNV TAS
ADCY2 adenylate cyclase 2 (brain) Mapped by significant region TAS
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 Mapped by significant region TAS
ADCY9 adenylate cyclase 9 Mapped by significant region TAS
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 Mapped by significant region TAS
RTN4 reticulon 4 Mapped by CNV TAS
RICTOR RPTOR independent companion of MTOR, complex 2 Mapped by significant region TAS
BAD BCL2-associated agonist of cell death Mapped by significant region TAS
PCSK6 proprotein convertase subtilisin/kexin type 6 Mapped by CNV TAS
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 Mapped by CNV; Mapped by significant region TAS
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A Mapped by significant region TAS
UBB ubiquitin B Mapped by significant region TAS
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 Mapped by significant region TAS
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) Mapped by PBA pathway TAS
ADCY4 adenylate cyclase 4 Mapped by significant region TAS
KIDINS220 kinase D-interacting substrate, 220kDa Mapped by significant region TAS
ADAM17 ADAM metallopeptidase domain 17 Mapped by significant region TAS
TSC2 tuberous sclerosis 2 Mapped by significant region TAS
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta Mapped by CNV TAS
PDPK1 3-phosphoinositide dependent protein kinase-1 Mapped by significant region TAS
BCAR1 breast cancer anti-estrogen resistance 1 Mapped by significant region ISS
SORT1 sortilin 1 Mapped by CNV IMP[14985763]
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Mapped by significant region TAS
UBC ubiquitin C Mapped by CNV TAS
SQSTM1 sequestosome 1 Mapped by CNV TAS
MAPK7 mitogen-activated protein kinase 7 Mapped by significant region TAS
MAPK3 mitogen-activated protein kinase 3 Mapped by CNV TAS
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 Mapped by Literature SNP TAS
FGD3 FYVE, RhoGEF and PH domain containing 3 Mapped by significant region TAS
RIT2 Ras-like without CAAX 2 Mapped by significant region TAS
BCL2L11 BCL2-like 11 (apoptosis facilitator) Mapped by LD-proxy TAS
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 Mapped by CNV TAS
ADORA2A adenosine A2a receptor Mapped by CNV TAS
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 Mapped by PBA pathway TAS
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) Mapped by significant region TAS
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 Mapped by significant region TAS
MAPK1 mitogen-activated protein kinase 1 Mapped by LD-proxy TAS
RTN4R reticulon 4 receptor Mapped by CNV TAS
NDN necdin, melanoma antigen (MAGE) family member Mapped by CNV; Mapped by significant region IEA
ADCY3 adenylate cyclase 3 Mapped by LD-proxy TAS
MAPKAP1 mitogen-activated protein kinase associated protein 1 Mapped by significant region TAS