Gene Report
Basic Info
Approved Symbol |
TRAF1
|
Symbol Alias |
EBI6 |
Approved Name |
TNF receptor-associated factor 1 |
Location |
9q33-q34 |
Position |
chr9:123664671-123691451, - |
External Links |
HGNC: 12031
Entrez Gene: 7185
Ensembl: ENSG00000056558
UCSC: uc004bku.1
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 11)
Gene related KEGG pathways (count: 2)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa05222 |
Small cell lung cancer |
16 |
Lung cancer is a leading cause of cancer death among men and......
Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control.
More...
|
hsa05200 |
Pathways in cancer |
52 |
|
Genes shared at least 5 GO terms with TRAF1 (count: 13)
Genes shared at least 2 KEGG pathways with TRAF1 (count: 14)
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