ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TRAF1
Symbol Alias	EBI6
Approved Name	TNF receptor-associated factor 1
Location	9q33-q34
Position	chr9:123664671-123691451, -
External Links	HGNC: 12031 Entrez Gene: 7185 Ensembl: ENSG00000056558 UCSC: uc004bku.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q33	chr9:117700000-130300000	2 (1/1/0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0031996	thioesterase binding	Molecular Function	IPI[11279055]	3
GO:0042981	regulation of apoptotic process	Biological Process	IDA[10692572]	32
GO:0008270	zinc ion binding	Molecular Function		323
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI[11279055]	23
GO:0006915	apoptotic process	Biological Process		111
GO:0007165	signal transduction	Biological Process		171
GO:0005737	cytoplasm	Cellular Component	TAS[8069916]	690
GO:0006461	protein complex assembly	Biological Process	TAS[8069916]	28
GO:0005515	protein binding	Molecular Function		910
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	RCA[19641626]	27
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process	IDA[10692572]	27

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05222	Small cell lung cancer	16	Lung cancer is a leading cause of cancer death among men and...... Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control. More...
hsa05200	Pathways in cancer	52

Genes shared at least 5 GO terms with TRAF1 (count: 13)

Gene Symbol	Pathway Count	Pathway List
PRKCB	7	zinc ion binding; apoptotic process; signal transduction; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity;
PRKD1	6	apoptotic process; signal transduction; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity;
MALT1	5	regulation of apoptotic process; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity;
UBB	5	regulation of apoptotic process; apoptotic process; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity;
UBC	5	regulation of apoptotic process; apoptotic process; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity;
BIRC3	5	zinc ion binding; apoptotic process; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
LPXN	5	zinc ion binding; signal transduction; cytoplasm; protein complex assembly; protein binding;
PARK2	5	zinc ion binding; ubiquitin protein ligase binding; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
RNF31	5	zinc ion binding; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity;
TRIM13	5	zinc ion binding; signal transduction; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
TRIM5	5	zinc ion binding; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity;
RELA	5	ubiquitin protein ligase binding; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity;
NEK6	5	apoptotic process; signal transduction; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;

Genes shared at least 2 KEGG pathways with TRAF1 (count: 14)

Gene Symbol	Pathway Count	Pathway List
BIRC2	2	Small cell lung cancer; Pathways in cancer;
BIRC3	2	Small cell lung cancer; Pathways in cancer;
CCND1	2	Small cell lung cancer; Pathways in cancer;
CYCS	2	Small cell lung cancer; Pathways in cancer;
FN1	2	Small cell lung cancer; Pathways in cancer;
ITGA2	2	Small cell lung cancer; Pathways in cancer;
LAMA2	2	Small cell lung cancer; Pathways in cancer;
LAMA3	2	Small cell lung cancer; Pathways in cancer;
LAMC1	2	Small cell lung cancer; Pathways in cancer;
LAMC2	2	Small cell lung cancer; Pathways in cancer;
PIK3CG	2	Small cell lung cancer; Pathways in cancer;
PIK3R1	2	Small cell lung cancer; Pathways in cancer;
RELA	2	Small cell lung cancer; Pathways in cancer;
SKP2	2	Small cell lung cancer; Pathways in cancer;

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Region: chr9:123664671..123691451 View in gBrowse