ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	BIRC3
Previous Symbol	API2
Symbol Alias	cIAP2, hiap-1, MIHC, RNF49, MALT2, c-IAP2
Approved Name	baculoviral IAP repeat containing 3
Previous Name	"baculoviral IAP repeat-containing 3"
Name Alias	"apoptosis inhibitor 2", "TNFR2-TRAF signaling complex protein", "mammalian IAP homolog C", "inhibitor of apoptosis protein 1"
Location	11q22
Position	chr11:102188215-102210134, 1
External Links	HGNC: 591 Entrez Gene: 330 Ensembl: ENSG00000023445 UCSC: uc001pgx.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)
11q22	chr11:97200000-110400000	1 (1/0/0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0038061	NIK/NF-kappaB cascade	biological process	TAS	3
GO:0006915	apoptotic process	biological process	IEA	127
GO:2000116	regulation of cysteine-type endopeptidase activity	biological process	TAS	2
GO:0034121	regulation of toll-like receptor signaling pathway	biological process	TAS	2
GO:0070266	necroptosis	biological process	IEA	2
GO:0005634	nucleus	cellular component	IDA[15665297]	877
GO:0060546	negative regulation of necroptosis	biological process	IEA	1
GO:0004842	ubiquitin-protein ligase activity	molecular function	IDA[16395405]	60
GO:0050727	regulation of inflammatory response	biological process	TAS	9
GO:0039535	regulation of RIG-I signaling pathway	biological process	TAS	2
GO:0045088	regulation of innate immune response	biological process	TAS	3
GO:0042326	negative regulation of phosphorylation	biological process	IEA	4
GO:0007166	cell surface receptor signaling pathway	biological process	TAS[8548810]	36
GO:0043066	negative regulation of apoptotic process	biological process	TAS[8552191]	85
GO:0005737	cytoplasm	cellular component	IDA[15665297]	781
GO:0005515	protein binding	molecular function	IPI	1015
GO:0070424	regulation of nucleotide-binding oligomerization domain containing signaling pathway	biological process	TAS	2
GO:0008270	zinc ion binding	molecular function	IEA	367
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	biological process	TAS	28
GO:2000378	negative regulation of reactive oxygen species metabolic process	biological process	IEA	3

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene
hsa04510	Focal adhesion	40
hsa05222	Small cell lung cancer	17
hsa04120	Ubiquitin mediated proteolysis	34
hsa04210	Apoptosis	13

Genes shared at least 5 GO terms with BIRC3 (count: 29)

Gene Symbol	Pathway Count	Pathway List
BIRC2	16	NIK/NF-kappaB cascade; apoptotic process; regulation of cysteine-type endopeptidase activity; regulation of toll-like receptor signaling pathway; necroptosis; nucleus; ubiquitin-protein ligase activity; regulation of inflammatory response; regulation of RIG-I signaling pathway; regulation of innate immune response; cell surface receptor signaling pathway; negative regulation of apoptotic process; protein binding; regulation of nucleotide-binding oligomerization domain containing signaling pathway; zinc ion binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
CBL	7	nucleus; ubiquitin-protein ligase activity; cell surface receptor signaling pathway; negative regulation of apoptotic process; cytoplasm; protein binding; zinc ion binding;
AATF	6	apoptotic process; nucleus; negative regulation of apoptotic process; cytoplasm; protein binding; negative regulation of reactive oxygen species metabolic process;
RELA	6	nucleus; regulation of inflammatory response; negative regulation of apoptotic process; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
MALT1	6	nucleus; ubiquitin-protein ligase activity; negative regulation of apoptotic process; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
TRIM32	6	nucleus; ubiquitin-protein ligase activity; negative regulation of apoptotic process; cytoplasm; protein binding; zinc ion binding;
BARD1	6	nucleus; ubiquitin-protein ligase activity; negative regulation of apoptotic process; cytoplasm; protein binding; zinc ion binding;
PARK2	6	nucleus; ubiquitin-protein ligase activity; cytoplasm; protein binding; zinc ion binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
TRIM5	6	nucleus; ubiquitin-protein ligase activity; cytoplasm; protein binding; zinc ion binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
TNFAIP3	6	nucleus; ubiquitin-protein ligase activity; negative regulation of apoptotic process; cytoplasm; protein binding; zinc ion binding;
APC	5	apoptotic process; nucleus; negative regulation of apoptotic process; cytoplasm; protein binding;
RNF130	5	apoptotic process; nucleus; ubiquitin-protein ligase activity; cytoplasm; zinc ion binding;
PRKD1	5	apoptotic process; nucleus; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
GATA6	5	apoptotic process; nucleus; negative regulation of apoptotic process; protein binding; zinc ion binding;
G2E3	5	apoptotic process; ubiquitin-protein ligase activity; negative regulation of apoptotic process; cytoplasm; zinc ion binding;
TRAF1	5	apoptotic process; cytoplasm; protein binding; zinc ion binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
BNIP3	5	apoptotic process; nucleus; negative regulation of apoptotic process; cytoplasm; protein binding;
RNF144B	5	apoptotic process; ubiquitin-protein ligase activity; cytoplasm; protein binding; zinc ion binding;
NEK6	5	apoptotic process; nucleus; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
SNCA	5	nucleus; negative regulation of apoptotic process; cytoplasm; protein binding; zinc ion binding;
HERC2	5	nucleus; ubiquitin-protein ligase activity; cytoplasm; protein binding; zinc ion binding;
MGRN1	5	nucleus; ubiquitin-protein ligase activity; cytoplasm; protein binding; zinc ion binding;
KLHL20	5	nucleus; ubiquitin-protein ligase activity; negative regulation of apoptotic process; cytoplasm; protein binding;
CRYAB	5	nucleus; negative regulation of apoptotic process; cytoplasm; protein binding; negative regulation of reactive oxygen species metabolic process;
RNF40	5	nucleus; ubiquitin-protein ligase activity; cytoplasm; protein binding; zinc ion binding;
RCHY1	5	nucleus; ubiquitin-protein ligase activity; cytoplasm; protein binding; zinc ion binding;
RNF31	5	ubiquitin-protein ligase activity; cytoplasm; protein binding; zinc ion binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
TRIM13	5	ubiquitin-protein ligase activity; cytoplasm; protein binding; zinc ion binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
NUP62	5	cell surface receptor signaling pathway; negative regulation of apoptotic process; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;

Genes shared at least 2 KEGG pathways with BIRC3 (count: 14)

Gene Symbol	Pathway Count	Pathway List
BIRC2	4	Focal adhesion; Small cell lung cancer; Ubiquitin mediated proteolysis; Apoptosis;
PIK3R1	3	Focal adhesion; Small cell lung cancer; Apoptosis;
PIK3CG	3	Focal adhesion; Small cell lung cancer; Apoptosis;
LAMC1	2	Focal adhesion; Small cell lung cancer;
BAD	2	Focal adhesion; Apoptosis;
LAMA2	2	Focal adhesion; Small cell lung cancer;
FN1	2	Focal adhesion; Small cell lung cancer;
LAMA3	2	Focal adhesion; Small cell lung cancer;
ITGA2	2	Focal adhesion; Small cell lung cancer;
CCND1	2	Focal adhesion; Small cell lung cancer;
LAMC2	2	Focal adhesion; Small cell lung cancer;
CYCS	2	Small cell lung cancer; Apoptosis;
RELA	2	Small cell lung cancer; Apoptosis;
SKP2	2	Small cell lung cancer; Ubiquitin mediated proteolysis;

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Region: chr11:102188215..102210134 View in gBrowse