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KEGG Pathway Report
Basic Info
| ID | hsa04621 |
|---|---|
| Name | NOD-like receptor signaling pathway |
| Description | Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. These NLRs include NALP1, NALP3 and Ipaf. The inflammasomes are critical for generating mature proinflammatory cytokines in concert with Toll-like receptor signaling pathway. |
| No. of Genes in ADHDgene | 16 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 16)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 16)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| MAPK9 | mitogen-activated protein kinase 9 | 5q35 | Mapped by CNV |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| SUGT1 | SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) | 13q12.2-q13.3 | Mapped by LD-proxy |
| BIRC2 | baculoviral IAP repeat containing 2 | 11q22 | Mapped by significant region |
| BIRC3 | baculoviral IAP repeat containing 3 | 11q22 | Mapped by significant region |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 6q23-q25 | Mapped by significant region |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| IL18 | interleukin 18 (interferon-gamma-inducing factor) | 11q22.2-q22.3 | Mapped by significant region |
| IL6 | interleukin 6 (interferon, beta 2) | 7p21-p15 | Mapped by significant region |
| CASP5 | caspase 5, apoptosis-related cysteine peptidase | 11q22.2-q22.3 | Mapped by significant region |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 11q13 | Mapped by significant region |
| PYCARD | PYD and CARD domain containing | 16p11.2 | Mapped by CNV |
| CARD18 | caspase recruitment domain family, member 18 | 11q22.3 | Mapped by significant region |
| PYDC1 | PYD (pyrin domain) containing 1 | 16p11.2 | Mapped by CNV |
| CARD6 | caspase recruitment domain family, member 6 | 5p13.1 | Mapped by significant region |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 11q23 | Mapped by significant region |