ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CASP5
Symbol Alias	ICE(rel)III
Approved Name	caspase 5, apoptosis-related cysteine peptidase
Previous Name	caspase 5, apoptosis-related cysteine protease
Location	11q22.2-q22.3
Position	chr11:104864962-104893895, -
External Links	HGNC: 1506 Entrez Gene: 838 Ensembl: ENSG00000137757 UCSC: uc010ruz.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)
11q22	chr11:97200000-110400000	1 (1/0/0)

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0072558	NLRP1 inflammasome complex	Cellular Component	IDA[12191486]	3
GO:0006915	apoptotic process	Biological Process		111
GO:0008234	cysteine-type peptidase activity	Molecular Function	TAS[7797592]	10
GO:0042981	regulation of apoptotic process	Biological Process		32
GO:0071260	cellular response to mechanical stimulus	Biological Process	IEP[19593445]	14
GO:0004197	cysteine-type endopeptidase activity	Molecular Function		17
GO:0006508	proteolysis	Biological Process		102

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04621	NOD-like receptor signaling pathway	16	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. These NLRs include NALP1, NALP3 and Ipaf. The inflammasomes are critical for generating mature proinflammatory cytokines in concert with Toll-like receptor signaling pathway. More...

Genes shared at least 5 GO terms with CASP5 (count: 1)

Gene Symbol	Pathway Count	Pathway List
CASP1	5	NLRP1 inflammasome complex; apoptotic process; cellular response to mechanical stimulus; cysteine-type endopeptidase activity; proteolysis;

Genes shared at least 2 KEGG pathways with CASP5 (count: 0)

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Region: chr11:104864962..104893895 View in gBrowse