ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TRIM32
Previous Symbol	LGMD2H
Symbol Alias	HT2A, TATIP, BBS11
Approved Name	tripartite motif containing 32
Previous Name	limb girdle muscular dystrophy 2H (autosomal recessive), "tripartite motif-containing 32"
Location	9q33.1
Position	chr9:119449581-119463579, +
External Links	HGNC: 16380 Entrez Gene: 22954 Ensembl: ENSG00000119401 UCSC: uc004bjw.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by CNV; Mapped by LD-proxy; Mapped by significant region

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lionel, A. C., 2011	Tests in a newly collected cohort of 349 unrelated individuals with ASD showed that deletions of TRIM32 yielded the strongest association with ADHD and ASD.	Trend

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 0)

LD-proxies (count: 1)

rs_ID	Location	Functional Annotation
rs17220476	Chr9:119452120(Fwd)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Lionel[2011]_16	chr9:0-0 (NCBI36 / hg18)	177	9q33.1	Loss	P
CNV_Lionel[2011]_17	chr9:0-0 (NCBI36 / hg18)	148	9q33.1	Loss	U

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q33	chr9:117700000-130300000	2 (1/1/0)
9q31.1-33.1	chr9:102600000-122500000	1 (1/0/0)

Gene related GO terms (count: 31)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 31)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045444	fat cell differentiation	Biological Process		9
GO:0045087	innate immune response	Biological Process	TAS[16175175]	54
GO:0045732	positive regulation of protein catabolic process	Biological Process		8
GO:0045666	positive regulation of neuron differentiation	Biological Process		13
GO:0043066	negative regulation of apoptotic process	Biological Process	IDA[18632609]	77
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Biological Process	IMP[19349376]	16
GO:0043621	protein self-association	Molecular Function	IDA[19349376]	8
GO:0043130	ubiquitin binding	Molecular Function	IDA[19349376]	9
GO:0030957	Tat protein binding	Molecular Function	TAS[16175175]	2
GO:0030335	positive regulation of cell migration	Biological Process	IDA[18632609]	29
GO:0034612	response to tumor necrosis factor	Biological Process		2
GO:0031369	translation initiation factor binding	Molecular Function		2
GO:0016567	protein ubiquitination	Biological Process	IDA[16816390]	41
GO:0009411	response to UV	Biological Process		5
GO:0030307	positive regulation of cell growth	Biological Process	IDA[18632609]	8
GO:0017022	myosin binding	Molecular Function		2
GO:0005634	nucleus	Cellular Component		770
GO:0005737	cytoplasm	Cellular Component	IDA[19349376]	690
GO:0005863	striated muscle myosin thick filament	Cellular Component		1
GO:0008270	zinc ion binding	Molecular Function		323
GO:0003713	transcription coactivator activity	Molecular Function	TAS[7778269]	52
GO:0003723	RNA binding	Molecular Function		104
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IDA[16816390]	52
GO:0005515	protein binding	Molecular Function	IPI[18632609]	910
GO:0000209	protein polyubiquitination	Biological Process	IDA[18632609]	23
GO:0048147	negative regulation of fibroblast proliferation	Biological Process		5
GO:0050769	positive regulation of neurogenesis	Biological Process		4
GO:0045787	positive regulation of cell cycle	Biological Process	IDA[18632609]	7
GO:0045862	positive regulation of proteolysis	Biological Process	IDA[18632609]	3
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process		27
GO:2000147	positive regulation of cell motility	Biological Process		2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04120	Ubiquitin mediated proteolysis	29	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...

Genes shared at least 5 GO terms with TRIM32 (count: 56)

Gene Symbol	Pathway Count	Pathway List
TNFAIP3	10	innate immune response; positive regulation of protein catabolic process; negative regulation of apoptotic process; protein self-association; ubiquitin binding; nucleus; cytoplasm; zinc ion binding; ubiquitin-protein ligase activity; protein binding;
MALT1	9	innate immune response; negative regulation of apoptotic process; protein self-association; protein ubiquitination; nucleus; cytoplasm; ubiquitin-protein ligase activity; protein binding; positive regulation of NF-kappaB transcription factor activity;
BARD1	9	positive regulation of protein catabolic process; negative regulation of apoptotic process; protein ubiquitination; nucleus; cytoplasm; zinc ion binding; RNA binding; ubiquitin-protein ligase activity; protein binding;
TRIM5	7	innate immune response; nucleus; cytoplasm; zinc ion binding; ubiquitin-protein ligase activity; protein binding; positive regulation of NF-kappaB transcription factor activity;
BIRC2	7	negative regulation of apoptotic process; nucleus; zinc ion binding; transcription coactivator activity; ubiquitin-protein ligase activity; protein binding; protein polyubiquitination;
CBL	7	negative regulation of apoptotic process; protein ubiquitination; nucleus; cytoplasm; zinc ion binding; ubiquitin-protein ligase activity; protein binding;
HERC2	7	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein ubiquitination; nucleus; cytoplasm; zinc ion binding; ubiquitin-protein ligase activity; protein binding;
PARK2	7	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; nucleus; cytoplasm; zinc ion binding; ubiquitin-protein ligase activity; protein binding; protein polyubiquitination;
RCHY1	7	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein ubiquitination; nucleus; cytoplasm; zinc ion binding; ubiquitin-protein ligase activity; protein binding;
RNF31	7	ubiquitin binding; cytoplasm; zinc ion binding; ubiquitin-protein ligase activity; protein binding; protein polyubiquitination; positive regulation of NF-kappaB transcription factor activity;
GSK3B	6	fat cell differentiation; positive regulation of protein catabolic process; negative regulation of apoptotic process; nucleus; cytoplasm; protein binding;
HERC5	6	innate immune response; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; nucleus; cytoplasm; ubiquitin-protein ligase activity; protein binding;
RELA	6	innate immune response; negative regulation of apoptotic process; nucleus; cytoplasm; protein binding; positive regulation of NF-kappaB transcription factor activity;
APC	6	positive regulation of protein catabolic process; negative regulation of apoptotic process; positive regulation of cell migration; nucleus; cytoplasm; protein binding;
BIRC3	6	negative regulation of apoptotic process; nucleus; cytoplasm; zinc ion binding; ubiquitin-protein ligase activity; protein binding;
KLHL20	6	negative regulation of apoptotic process; protein ubiquitination; nucleus; cytoplasm; ubiquitin-protein ligase activity; protein binding;
TFAP2A	6	negative regulation of apoptotic process; positive regulation of cell migration; nucleus; cytoplasm; transcription coactivator activity; protein binding;
NEDD4L	6	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein ubiquitination; nucleus; cytoplasm; ubiquitin-protein ligase activity; protein binding;
TRIP12	6	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein ubiquitination; nucleus; cytoplasm; ubiquitin-protein ligase activity; protein binding;
UBE3A	6	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; nucleus; cytoplasm; transcription coactivator activity; ubiquitin-protein ligase activity; protein binding;
WWP1	6	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein ubiquitination; nucleus; cytoplasm; ubiquitin-protein ligase activity; protein binding;
RNF20	6	nucleus; zinc ion binding; transcription coactivator activity; ubiquitin-protein ligase activity; protein binding; protein polyubiquitination;
MED1	5	fat cell differentiation; negative regulation of apoptotic process; nucleus; transcription coactivator activity; protein binding;
CORO1A	5	innate immune response; positive regulation of cell migration; nucleus; cytoplasm; protein binding;
MAPK1	5	innate immune response; positive regulation of cell migration; nucleus; cytoplasm; protein binding;
PRKD1	5	innate immune response; nucleus; cytoplasm; protein binding; positive regulation of NF-kappaB transcription factor activity;
PYCARD	5	innate immune response; nucleus; cytoplasm; protein binding; positive regulation of NF-kappaB transcription factor activity;
G2E3	5	negative regulation of apoptotic process; cytoplasm; zinc ion binding; ubiquitin-protein ligase activity; protein polyubiquitination;
GSTP1	5	negative regulation of apoptotic process; nucleus; cytoplasm; protein binding; negative regulation of fibroblast proliferation;
INS	5	negative regulation of apoptotic process; positive regulation of cell migration; positive regulation of cell growth; protein binding; positive regulation of NF-kappaB transcription factor activity;
PLK1	5	negative regulation of apoptotic process; protein ubiquitination; nucleus; protein binding; positive regulation of proteolysis;
SNCA	5	negative regulation of apoptotic process; nucleus; cytoplasm; zinc ion binding; protein binding;
SYVN1	5	negative regulation of apoptotic process; protein ubiquitination; nucleus; zinc ion binding; protein binding;
XRCC5	5	negative regulation of apoptotic process; nucleus; cytoplasm; protein binding; positive regulation of neurogenesis;
YAP1	5	negative regulation of apoptotic process; nucleus; cytoplasm; transcription coactivator activity; protein binding;
HECTD1	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; nucleus; cytoplasm; ubiquitin-protein ligase activity; protein binding;
RNF144B	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; zinc ion binding; ubiquitin-protein ligase activity; protein binding;
RNF146	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; nucleus; zinc ion binding; ubiquitin-protein ligase activity; protein binding;
ADAM8	5	protein self-association; cytoplasm; zinc ion binding; protein binding; positive regulation of NF-kappaB transcription factor activity;
ADAM17	5	positive regulation of cell migration; positive regulation of cell growth; cytoplasm; zinc ion binding; protein binding;
CELF1	5	translation initiation factor binding; nucleus; cytoplasm; RNA binding; protein binding;
FBXO4	5	protein ubiquitination; cytoplasm; ubiquitin-protein ligase activity; protein binding; protein polyubiquitination;
RFWD2	5	protein ubiquitination; nucleus; cytoplasm; zinc ion binding; protein binding;
RFWD3	5	protein ubiquitination; nucleus; cytoplasm; zinc ion binding; ubiquitin-protein ligase activity;
RNF25	5	protein ubiquitination; nucleus; zinc ion binding; ubiquitin-protein ligase activity; positive regulation of NF-kappaB transcription factor activity;
ERCC8	5	response to UV; nucleus; ubiquitin-protein ligase activity; protein binding; protein polyubiquitination;
NOL8	5	positive regulation of cell growth; nucleus; cytoplasm; RNA binding; protein binding;
FUS	5	nucleus; cytoplasm; zinc ion binding; RNA binding; protein binding;
IGHMBP2	5	nucleus; cytoplasm; zinc ion binding; RNA binding; protein binding;
PRKCB	5	nucleus; cytoplasm; zinc ion binding; protein binding; positive regulation of NF-kappaB transcription factor activity;
PRPF19	5	nucleus; cytoplasm; ubiquitin-protein ligase activity; protein binding; protein polyubiquitination;
PSMC3	5	nucleus; cytoplasm; transcription coactivator activity; protein binding; protein polyubiquitination;
RBM4	5	nucleus; cytoplasm; zinc ion binding; RNA binding; protein binding;
RNF40	5	nucleus; cytoplasm; zinc ion binding; ubiquitin-protein ligase activity; protein binding;
ZFR	5	nucleus; cytoplasm; zinc ion binding; RNA binding; protein binding;
LRSAM1	5	cytoplasm; zinc ion binding; ubiquitin-protein ligase activity; protein binding; protein polyubiquitination;

Genes shared at least 2 KEGG pathways with TRIM32 (count: 0)

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Region: chr9:119449581..119463579 View in gBrowse