ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TRIM32
Previous Symbol	LGMD2H
Symbol Alias	HT2A, TATIP, BBS11
Approved Name	tripartite motif containing 32
Previous Name	"limb girdle muscular dystrophy 2H (autosomal recessive)", "tripartite motif-containing 32"
Location	9q33.1
Position	chr9:119449581-119463579, 1
External Links	HGNC: 16380 Entrez Gene: 22954 Ensembl: ENSG00000119401 UCSC: uc004bjx.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by LD-proxy; Mapped by significant region

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lionel, A. C., 2011	Tests in a newly collected cohort of 349 unrelated individuals with ASD showed that deletions of TRIM32 yielded the strongest association with ADHD and ASD.	Trend

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 0)

LD-proxies (count: 1)

rs_ID	Location	Functional Annotation
rs17220476	chr9:119452120(Fwd)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q33	chr9:117700000-130300000	2 (1/1/0)
9q31.1-33.1	chr9:102600000-122500000	1 (1/0/0)

Gene related GO terms (count: 31)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 31)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0043621	protein self-association	molecular function	IDA[19349376]	9
GO:0005737	cytoplasm	cellular component	IDA[19349376]	781
GO:0045732	positive regulation of protein catabolic process	biological process	ISS	9
GO:0005863	striated muscle myosin thick filament	cellular component	ISS	1
GO:0005634	nucleus	cellular component	ISS	877
GO:0003713	transcription coactivator activity	molecular function	TAS[7778269]	58
GO:2000147	positive regulation of cell motility	biological process	ISS	2
GO:0050769	positive regulation of neurogenesis	biological process	ISS	4
GO:0045087	innate immune response	biological process	TAS[16175175]	57
GO:0016567	protein ubiquitination	biological process	IDA[16816390]	48
GO:0003723	RNA binding	molecular function	ISS	115
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological process	ISS	27
GO:0045444	fat cell differentiation	biological process	ISS	12
GO:0017022	myosin binding	molecular function	ISS	2
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological process	IMP[19349376]	15
GO:0034612	response to tumor necrosis factor	biological process	ISS	2
GO:0005515	protein binding	molecular function	IPI[18632609]	1015
GO:0008270	zinc ion binding	molecular function	IEA	367
GO:0004842	ubiquitin-protein ligase activity	molecular function	IDA[16816390]	60
GO:0031369	translation initiation factor binding	molecular function	ISS	2
GO:0045862	positive regulation of proteolysis	biological process	IDA[18632609]	3
GO:0009411	response to UV	biological process	ISS	8
GO:0043130	ubiquitin binding	molecular function	IDA[19349376]	9
GO:0045787	positive regulation of cell cycle	biological process	IDA[18632609]	7
GO:0030335	positive regulation of cell migration	biological process	IDA[18632609]	28
GO:0045666	positive regulation of neuron differentiation	biological process	ISS	13
GO:0030307	positive regulation of cell growth	biological process	IDA[18632609]	9
GO:0000209	protein polyubiquitination	biological process	IDA[18632609]	26
GO:0048147	negative regulation of fibroblast proliferation	biological process	ISS	5
GO:0030957	Tat protein binding	molecular function	TAS[16175175]	2
GO:0043066	negative regulation of apoptotic process	biological process	IDA[18632609]	85

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04120	Ubiquitin mediated proteolysis	34

Genes shared at least 5 GO terms with TRIM32 (count: 58)

Gene Symbol	Pathway Count	Pathway List
TNFAIP3	10	protein self-association; cytoplasm; positive regulation of protein catabolic process; nucleus; innate immune response; protein binding; zinc ion binding; ubiquitin-protein ligase activity; ubiquitin binding; negative regulation of apoptotic process;
MALT1	9	protein self-association; cytoplasm; nucleus; innate immune response; protein ubiquitination; positive regulation of NF-kappaB transcription factor activity; protein binding; ubiquitin-protein ligase activity; negative regulation of apoptotic process;
BARD1	9	cytoplasm; positive regulation of protein catabolic process; nucleus; protein ubiquitination; RNA binding; protein binding; zinc ion binding; ubiquitin-protein ligase activity; negative regulation of apoptotic process;
CBL	7	cytoplasm; nucleus; protein ubiquitination; protein binding; zinc ion binding; ubiquitin-protein ligase activity; negative regulation of apoptotic process;
PARK2	7	cytoplasm; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; zinc ion binding; ubiquitin-protein ligase activity; protein polyubiquitination;
HERC2	7	cytoplasm; nucleus; protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; zinc ion binding; ubiquitin-protein ligase activity;
RCHY1	7	cytoplasm; nucleus; protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; zinc ion binding; ubiquitin-protein ligase activity;
RNF31	7	cytoplasm; positive regulation of NF-kappaB transcription factor activity; protein binding; zinc ion binding; ubiquitin-protein ligase activity; ubiquitin binding; protein polyubiquitination;
TRIM5	7	cytoplasm; nucleus; innate immune response; positive regulation of NF-kappaB transcription factor activity; protein binding; zinc ion binding; ubiquitin-protein ligase activity;
BIRC2	7	nucleus; transcription coactivator activity; protein binding; zinc ion binding; ubiquitin-protein ligase activity; protein polyubiquitination; negative regulation of apoptotic process;
AXIN1	6	protein self-association; cytoplasm; positive regulation of protein catabolic process; nucleus; protein binding; protein polyubiquitination;
HERC5	6	cytoplasm; nucleus; innate immune response; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity;
NEDD4L	6	cytoplasm; nucleus; protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity;
BIRC3	6	cytoplasm; nucleus; protein binding; zinc ion binding; ubiquitin-protein ligase activity; negative regulation of apoptotic process;
MGRN1	6	cytoplasm; nucleus; protein binding; zinc ion binding; ubiquitin-protein ligase activity; protein polyubiquitination;
RELA	6	cytoplasm; nucleus; innate immune response; positive regulation of NF-kappaB transcription factor activity; protein binding; negative regulation of apoptotic process;
UBE3A	6	cytoplasm; nucleus; transcription coactivator activity; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity;
KLHL20	6	cytoplasm; nucleus; protein ubiquitination; protein binding; ubiquitin-protein ligase activity; negative regulation of apoptotic process;
APC	6	cytoplasm; positive regulation of protein catabolic process; nucleus; protein binding; positive regulation of cell migration; negative regulation of apoptotic process;
CREBBP	6	cytoplasm; nucleus; transcription coactivator activity; innate immune response; protein binding; zinc ion binding;
GSK3B	6	cytoplasm; positive regulation of protein catabolic process; nucleus; fat cell differentiation; protein binding; negative regulation of apoptotic process;
TRIP12	6	cytoplasm; nucleus; protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity;
RNF20	6	nucleus; transcription coactivator activity; protein binding; zinc ion binding; ubiquitin-protein ligase activity; protein polyubiquitination;
ADAM8	5	protein self-association; cytoplasm; positive regulation of NF-kappaB transcription factor activity; protein binding; zinc ion binding;
PRPF19	5	cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; protein polyubiquitination;
RFWD3	5	cytoplasm; nucleus; protein ubiquitination; zinc ion binding; ubiquitin-protein ligase activity;
SNCA	5	cytoplasm; nucleus; protein binding; zinc ion binding; negative regulation of apoptotic process;
NOL8	5	cytoplasm; nucleus; RNA binding; protein binding; positive regulation of cell growth;
FBXO4	5	cytoplasm; protein ubiquitination; protein binding; ubiquitin-protein ligase activity; protein polyubiquitination;
GSTP1	5	cytoplasm; nucleus; protein binding; negative regulation of fibroblast proliferation; negative regulation of apoptotic process;
PRKD1	5	cytoplasm; nucleus; innate immune response; positive regulation of NF-kappaB transcription factor activity; protein binding;
FUS	5	cytoplasm; nucleus; RNA binding; protein binding; zinc ion binding;
RNF144B	5	cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; zinc ion binding; ubiquitin-protein ligase activity;
YAP1	5	cytoplasm; nucleus; transcription coactivator activity; protein binding; negative regulation of apoptotic process;
LRSAM1	5	cytoplasm; protein binding; zinc ion binding; ubiquitin-protein ligase activity; protein polyubiquitination;
RBM4	5	cytoplasm; nucleus; RNA binding; protein binding; zinc ion binding;
PYCARD	5	cytoplasm; nucleus; innate immune response; positive regulation of NF-kappaB transcription factor activity; protein binding;
CORO1A	5	cytoplasm; nucleus; innate immune response; protein binding; positive regulation of cell migration;
ADAM17	5	cytoplasm; protein binding; zinc ion binding; positive regulation of cell migration; positive regulation of cell growth;
E4F1	5	cytoplasm; transcription coactivator activity; protein ubiquitination; protein binding; zinc ion binding;
IGHMBP2	5	cytoplasm; nucleus; RNA binding; protein binding; zinc ion binding;
XRCC5	5	cytoplasm; nucleus; positive regulation of neurogenesis; protein binding; negative regulation of apoptotic process;
HECTD1	5	cytoplasm; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity;
G2E3	5	cytoplasm; zinc ion binding; ubiquitin-protein ligase activity; protein polyubiquitination; negative regulation of apoptotic process;
ZFR	5	cytoplasm; nucleus; RNA binding; protein binding; zinc ion binding;
RNF40	5	cytoplasm; nucleus; protein binding; zinc ion binding; ubiquitin-protein ligase activity;
SOCS1	5	cytoplasm; nucleus; protein ubiquitination; fat cell differentiation; protein binding;
PSMC3	5	cytoplasm; nucleus; transcription coactivator activity; protein binding; protein polyubiquitination;
MAPK1	5	cytoplasm; nucleus; innate immune response; protein binding; positive regulation of cell migration;
CELF1	5	cytoplasm; nucleus; RNA binding; protein binding; translation initiation factor binding;
SYVN1	5	nucleus; protein ubiquitination; protein binding; zinc ion binding; negative regulation of apoptotic process;
TFAP2B	5	nucleus; transcription coactivator activity; fat cell differentiation; protein binding; negative regulation of apoptotic process;
RNF25	5	nucleus; protein ubiquitination; positive regulation of NF-kappaB transcription factor activity; zinc ion binding; ubiquitin-protein ligase activity;
MED1	5	nucleus; transcription coactivator activity; fat cell differentiation; protein binding; negative regulation of apoptotic process;
PLK1	5	nucleus; protein ubiquitination; protein binding; positive regulation of proteolysis; negative regulation of apoptotic process;
ERCC8	5	nucleus; protein binding; ubiquitin-protein ligase activity; response to UV; protein polyubiquitination;
RNF146	5	nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; zinc ion binding; ubiquitin-protein ligase activity;
INS	5	positive regulation of NF-kappaB transcription factor activity; protein binding; positive regulation of cell migration; positive regulation of cell growth; negative regulation of apoptotic process;

Genes shared at least 2 KEGG pathways with TRIM32 (count: 0)

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Region: chr9:119449581..119463579 View in gBrowse