ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RNF20
Symbol Alias	FLJ20382, FLJ11189, KAIA2779, BRE1A, hBRE1, BRE1
Approved Name	ring finger protein 20
Name Alias	BRE1 E3 ubiquitin ligase homolog (S. cerevisiae)
Location	9q22
Position	chr9:104296133-104325626, +
External Links	HGNC: 10062 Entrez Gene: 56254 Ensembl: ENSG00000155827 UCSC: uc004bbn.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q31.1-33.1	chr9:102600000-122500000	1 (1/0/0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0010390	histone monoubiquitination	Biological Process	IDA[16307923]	2
GO:0008270	zinc ion binding	Molecular Function		323
GO:0031062	positive regulation of histone methylation	Biological Process		2
GO:0030336	negative regulation of cell migration	Biological Process	IDA[18832071]	13
GO:0005730	nucleolus	Cellular Component	IDA[19037095]	243
GO:0005634	nucleus	Cellular Component	IDA[16307923]	770
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IMP[19037095]	25
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IMP[18832071]	158
GO:0003713	transcription coactivator activity	Molecular Function	IDA[16337599]	52
GO:0003682	chromatin binding	Molecular Function		48
GO:0005515	protein binding	Molecular Function	IPI[19410543]	910
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IDA[19037095,16307923]	52
GO:0000151	ubiquitin ligase complex	Cellular Component	IDA[16307923]	15
GO:0002039	p53 binding	Molecular Function	IDA[16337599]	11
GO:0000209	protein polyubiquitination	Biological Process	IDA[19037095]	23
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IMP[16713563]	80
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI[16307923]	23
GO:0033503	HULC complex	Cellular Component	IDA[19410543]	2
GO:0033523	histone H2B ubiquitination	Biological Process	IDA[16307923]	2
GO:0042393	histone binding	Molecular Function	IDA[16337599]	9

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with RNF20 (count: 35)

Gene Symbol	Pathway Count	Pathway List
RNF40	11	histone monoubiquitination; zinc ion binding; nucleolus; nucleus; ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex; ubiquitin protein ligase binding; HULC complex; histone H2B ubiquitination;
HINFP	9	zinc ion binding; nucleolus; nucleus; regulation of transcription, DNA-dependent; transcription coactivator activity; chromatin binding; protein binding; positive regulation of transcription, DNA-dependent; histone binding;
BIRC2	7	zinc ion binding; nucleus; regulation of transcription, DNA-dependent; transcription coactivator activity; protein binding; ubiquitin-protein ligase activity; protein polyubiquitination;
PARK2	7	zinc ion binding; nucleus; ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity; protein polyubiquitination; ubiquitin protein ligase binding;
RCHY1	7	zinc ion binding; nucleolus; nucleus; protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex; p53 binding;
RNF2	7	zinc ion binding; nucleolus; nucleus; chromatin binding; protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex;
TRIM32	6	zinc ion binding; nucleus; transcription coactivator activity; protein binding; ubiquitin-protein ligase activity; protein polyubiquitination;
DAXX	6	nucleolus; nucleus; regulation of transcription, DNA-dependent; protein binding; p53 binding; ubiquitin protein ligase binding;
MED1	6	nucleolus; nucleus; transcription coactivator activity; chromatin binding; protein binding; positive regulation of transcription, DNA-dependent;
NCOA6	6	nucleolus; nucleus; transcription coactivator activity; chromatin binding; protein binding; positive regulation of transcription, DNA-dependent;
TFAP2A	6	nucleolus; nucleus; transcription coactivator activity; chromatin binding; protein binding; positive regulation of transcription, DNA-dependent;
APBB1	6	nucleus; regulation of transcription, DNA-dependent; chromatin binding; protein binding; positive regulation of transcription, DNA-dependent; histone binding;
BARD1	5	zinc ion binding; nucleus; protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex;
CBL	5	zinc ion binding; nucleus; regulation of transcription, DNA-dependent; protein binding; ubiquitin-protein ligase activity;
HERC2	5	zinc ion binding; nucleus; protein binding; ubiquitin-protein ligase activity; ubiquitin protein ligase binding;
MTA2	5	zinc ion binding; nucleolus; nucleus; chromatin binding; protein binding;
NR5A1	5	zinc ion binding; nucleus; transcription coactivator activity; chromatin binding; protein binding;
PHF2	5	zinc ion binding; nucleolus; nucleus; transcription coactivator activity; protein binding;
PRKCB	5	zinc ion binding; nucleus; chromatin binding; protein binding; histone binding;
RSF1	5	zinc ion binding; nucleus; protein binding; positive regulation of transcription, DNA-dependent; histone binding;
TRIM5	5	zinc ion binding; nucleolus; nucleus; protein binding; ubiquitin-protein ligase activity;
USP22	5	zinc ion binding; ubiquitin-dependent protein catabolic process; transcription coactivator activity; protein binding; positive regulation of transcription, DNA-dependent;
MEN1	5	positive regulation of histone methylation; nucleolus; nucleus; chromatin binding; protein binding;
GSK3B	5	nucleolus; nucleus; protein binding; p53 binding; ubiquitin protein ligase binding;
KAT5	5	nucleolus; nucleus; transcription coactivator activity; protein binding; positive regulation of transcription, DNA-dependent;
RCC1	5	nucleolus; nucleus; chromatin binding; protein binding; histone binding;
SMARCB1	5	nucleolus; nucleus; transcription coactivator activity; protein binding; p53 binding;
SSRP1	5	nucleolus; nucleus; regulation of transcription, DNA-dependent; chromatin binding; protein binding;
SUPT3H	5	nucleolus; nucleus; regulation of transcription, DNA-dependent; transcription coactivator activity; positive regulation of transcription, DNA-dependent;
THRAP3	5	nucleolus; nucleus; transcription coactivator activity; protein binding; positive regulation of transcription, DNA-dependent;
FBXO7	5	nucleus; ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex;
PRPF19	5	nucleus; protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex; protein polyubiquitination;
RELA	5	nucleus; chromatin binding; protein binding; positive regulation of transcription, DNA-dependent; ubiquitin protein ligase binding;
UBE3A	5	nucleus; ubiquitin-dependent protein catabolic process; transcription coactivator activity; protein binding; ubiquitin-protein ligase activity;
FBXO4	5	ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex; protein polyubiquitination;

Genes shared at least 2 KEGG pathways with RNF20 (count: 0)

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Region: chr9:104296133..104325626 View in gBrowse