ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	THRAP3
Symbol Alias	TRAP150
Approved Name	thyroid hormone receptor associated protein 3
Location	1p34.3
Position	chr1:36690017-36770958, +
External Links	HGNC: 22964 Entrez Gene: 9967 Ensembl: ENSG00000054118 UCSC: uc001cae.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 27)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051219	phosphoprotein binding	Molecular Function		4
GO:0048255	mRNA stabilization	Biological Process	IMP[18794151]	3
GO:0048026	positive regulation of mRNA splicing, via spliceosome	Biological Process		4
GO:0046966	thyroid hormone receptor binding	Molecular Function	IDA[10198638]	18
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[12037571]	131
GO:0008380	RNA splicing	Biological Process		65
GO:0016592	mediator complex	Cellular Component	IDA[12037571]	17
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	IDA[12218053]	42
GO:0006397	mRNA processing	Biological Process		50
GO:0005634	nucleus	Cellular Component		770
GO:0005730	nucleolus	Cellular Component		243
GO:0005515	protein binding	Molecular Function		910
GO:0005524	ATP binding	Molecular Function		228
GO:0043231	intracellular membrane-bounded organelle	Cellular Component		62
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[10198638]	80
GO:0042809	vitamin D receptor binding	Molecular Function	NAS[10235266]	11
GO:0030521	androgen receptor signaling pathway	Biological Process	IDA[12218053]	16
GO:0035145	exon-exon junction complex	Cellular Component		1
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Molecular Function	NAS[10235266]	19
GO:0030518	intracellular steroid hormone receptor signaling pathway	Biological Process	IDA[11867769]	10
GO:0000956	nuclear-transcribed mRNA catabolic process	Biological Process		2
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	Biological Process		4
GO:0003712	transcription cofactor activity	Molecular Function	IDA[12218053]	17
GO:0001104	RNA polymerase II transcription cofactor activity	Molecular Function	IDA[10198638]	16
GO:0004872	receptor activity	Molecular Function	IDA[12218053]	36
GO:0003713	transcription coactivator activity	Molecular Function	IDA[12037571]	52

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with THRAP3 (count: 60)

Gene Symbol	Pathway Count	Pathway List
MED1	17	thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; mediator complex; transcription initiation from RNA polymerase II promoter; nucleus; nucleolus; protein binding; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; vitamin D receptor binding; androgen receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; transcription cofactor activity; RNA polymerase II transcription cofactor activity; receptor activity; transcription coactivator activity;
MED12	15	thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; mediator complex; transcription initiation from RNA polymerase II promoter; nucleus; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; vitamin D receptor binding; androgen receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; transcription cofactor activity; RNA polymerase II transcription cofactor activity; receptor activity; transcription coactivator activity;
MED13	15	thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; mediator complex; transcription initiation from RNA polymerase II promoter; nucleus; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; vitamin D receptor binding; androgen receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; transcription cofactor activity; RNA polymerase II transcription cofactor activity; receptor activity; transcription coactivator activity;
MED14	15	thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; mediator complex; transcription initiation from RNA polymerase II promoter; nucleus; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; vitamin D receptor binding; androgen receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; transcription cofactor activity; RNA polymerase II transcription cofactor activity; receptor activity; transcription coactivator activity;
MED17	15	thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; mediator complex; transcription initiation from RNA polymerase II promoter; nucleus; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; vitamin D receptor binding; androgen receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; transcription cofactor activity; RNA polymerase II transcription cofactor activity; receptor activity; transcription coactivator activity;
MED4	15	thyroid hormone receptor binding; mediator complex; transcription initiation from RNA polymerase II promoter; nucleus; nucleolus; protein binding; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; vitamin D receptor binding; androgen receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; transcription cofactor activity; RNA polymerase II transcription cofactor activity; receptor activity;
MED30	14	thyroid hormone receptor binding; mediator complex; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; vitamin D receptor binding; androgen receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; transcription cofactor activity; RNA polymerase II transcription cofactor activity; receptor activity;
MED24	13	thyroid hormone receptor binding; mediator complex; transcription initiation from RNA polymerase II promoter; nucleus; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; vitamin D receptor binding; androgen receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; transcription cofactor activity; RNA polymerase II transcription cofactor activity; receptor activity;
MED16	12	thyroid hormone receptor binding; mediator complex; transcription initiation from RNA polymerase II promoter; nucleus; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; vitamin D receptor binding; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; transcription cofactor activity; receptor activity; transcription coactivator activity;
NCOA6	11	thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleus; nucleolus; protein binding; intracellular membrane-bounded organelle; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; transcription coactivator activity;
SNW1	9	positive regulation of mRNA splicing, via spliceosome; positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleus; nucleolus; protein binding; nuclear hormone receptor binding; vitamin D receptor binding; transcription coactivator activity;
KAT5	7	positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; protein binding; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; transcription coactivator activity;
MAML1	7	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleus; nucleolus; protein binding; intracellular membrane-bounded organelle; transcription coactivator activity;
NRIP1	7	positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; androgen receptor signaling pathway; transcription coactivator activity;
RBM14	7	positive regulation of transcription from RNA polymerase II promoter; mediator complex; nucleus; nucleolus; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; RNA polymerase II transcription cofactor activity;
TFAP2A	7	positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; protein binding; intracellular membrane-bounded organelle; positive regulation of transcription, DNA-dependent; transcription coactivator activity;
PPARGC1B	6	positive regulation of transcription from RNA polymerase II promoter; mediator complex; nucleus; nuclear hormone receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; RNA polymerase II transcription cofactor activity;
PRPF6	6	positive regulation of transcription from RNA polymerase II promoter; RNA splicing; nucleus; protein binding; nuclear hormone receptor binding; transcription coactivator activity;
CDK12	6	RNA splicing; mRNA processing; nucleus; nucleolus; protein binding; ATP binding;
HSPA8	6	RNA splicing; mRNA processing; nucleus; nucleolus; protein binding; ATP binding;
RBM4	6	RNA splicing; mRNA processing; nucleus; nucleolus; protein binding; regulation of alternative mRNA splicing, via spliceosome;
SMARCD3	6	nucleus; protein binding; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; transcription coactivator activity;
NSD1	5	thyroid hormone receptor binding; nucleus; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; transcription cofactor activity;
NUP62	5	thyroid hormone receptor binding; protein binding; intracellular membrane-bounded organelle; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding;
ATXN1	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; protein binding; intracellular membrane-bounded organelle;
GSK3B	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; protein binding; ATP binding;
HNF1B	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; protein binding; positive regulation of transcription, DNA-dependent;
MAPK3	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; protein binding; ATP binding;
MEN1	5	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleus; nucleolus; protein binding;
NCOA7	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; nuclear hormone receptor binding; ligand-dependent nuclear receptor transcription coactivator activity;
NR5A1	5	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; transcription coactivator activity;
RBPJ	5	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleus; nucleolus; protein binding;
RPS6KA4	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; protein binding; ATP binding;
SMARCB1	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; nucleolus; protein binding; transcription coactivator activity;
TP53BP1	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; positive regulation of transcription, DNA-dependent; RNA polymerase II transcription cofactor activity;
UBE3A	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; androgen receptor signaling pathway; transcription coactivator activity;
YAP1	5	positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; transcription coactivator activity;
DDX23	5	RNA splicing; nucleus; nucleolus; protein binding; ATP binding;
DHX15	5	RNA splicing; mRNA processing; nucleus; nucleolus; ATP binding;
DHX8	5	RNA splicing; nucleus; nucleolus; protein binding; ATP binding;
DHX9	5	RNA splicing; nucleus; nucleolus; protein binding; ATP binding;
EFTUD2	5	RNA splicing; mRNA processing; nucleus; nucleolus; protein binding;
HNRNPA2B1	5	RNA splicing; mRNA processing; nucleus; nucleolus; protein binding;
NSRP1	5	RNA splicing; mRNA processing; nucleus; protein binding; regulation of alternative mRNA splicing, via spliceosome;
SF3A1	5	RNA splicing; mRNA processing; nucleus; nucleolus; protein binding;
SF3A3	5	RNA splicing; mRNA processing; nucleus; nucleolus; protein binding;
SMC1A	5	RNA splicing; nucleus; nucleolus; protein binding; ATP binding;
SNRNP200	5	RNA splicing; nucleus; nucleolus; protein binding; ATP binding;
TARDBP	5	RNA splicing; mRNA processing; nucleus; nucleolus; protein binding;
U2AF1	5	RNA splicing; mRNA processing; nucleus; nucleolus; protein binding;
MED15	5	mediator complex; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; RNA polymerase II transcription cofactor activity;
MED7	5	mediator complex; transcription initiation from RNA polymerase II promoter; protein binding; RNA polymerase II transcription cofactor activity; transcription coactivator activity;
PGR	5	transcription initiation from RNA polymerase II promoter; nucleus; nucleolus; protein binding; intracellular membrane-bounded organelle;
DAXX	5	nucleus; nucleolus; protein binding; nuclear hormone receptor binding; androgen receptor signaling pathway;
HINFP	5	nucleus; nucleolus; protein binding; positive regulation of transcription, DNA-dependent; transcription coactivator activity;
HMGA1	5	nucleus; protein binding; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; ligand-dependent nuclear receptor transcription coactivator activity;
MAPK1	5	nucleus; nucleolus; protein binding; ATP binding; positive regulation of transcription, DNA-dependent;
MMS19	5	nucleus; protein binding; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; transcription coactivator activity;
RNF20	5	nucleus; nucleolus; protein binding; positive regulation of transcription, DNA-dependent; transcription coactivator activity;
TGFB1I1	5	protein binding; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; androgen receptor signaling pathway; transcription coactivator activity;

Genes shared at least 2 KEGG pathways with THRAP3 (count: 0)

View in gBrowse

Region: chr1:36690017..36770958 View in gBrowse