ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MED17
Previous Symbol	CRSP6
Symbol Alias	CRSP77, TRAP80, DRIP80
Approved Name	mediator complex subunit 17
Previous Name	cofactor required for Sp1 transcriptional activation, subunit 6 (77kD), "cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa"
Location	11q21
Position	chr11:93517393-93547861, +
External Links	HGNC: 2375 Entrez Gene: 9440 Ensembl: ENSG00000042429 UCSC: uc001pem.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005667	transcription factor complex	Cellular Component	IDA[9989412]	51
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005634	nucleus	Cellular Component	IDA[10235267]	770
GO:0004872	receptor activity	Molecular Function	IDA[12218053]	36
GO:0003713	transcription coactivator activity	Molecular Function	IDA[12037571]	52
GO:0003712	transcription cofactor activity	Molecular Function	IDA[12218053]	17
GO:0001104	RNA polymerase II transcription cofactor activity	Molecular Function	IDA[10198638]	16
GO:0030521	androgen receptor signaling pathway	Biological Process	IDA[12218053]	16
GO:0030518	intracellular steroid hormone receptor signaling pathway	Biological Process	IDA[11867769]	10
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Molecular Function	NAS[10235266]	19
GO:0019827	stem cell maintenance	Biological Process		12
GO:0016592	mediator complex	Cellular Component	IDA[14638676]	17
GO:0010467	gene expression	Biological Process		140
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	IDA[12218053]	42
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[9989412]	42
GO:0042809	vitamin D receptor binding	Molecular Function	NAS[10235266]	11
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[10198638]	80
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[12037571]	131
GO:0046966	thyroid hormone receptor binding	Molecular Function	IDA[10198638]	18

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MED17 (count: 39)

Gene Symbol	Pathway Count	Pathway List
MED14	19	nucleoplasm; nucleus; receptor activity; transcription coactivator activity; transcription cofactor activity; RNA polymerase II transcription cofactor activity; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; stem cell maintenance; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; nuclear hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; thyroid hormone receptor binding;
MED12	18	nucleoplasm; nucleus; receptor activity; transcription coactivator activity; transcription cofactor activity; RNA polymerase II transcription cofactor activity; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; stem cell maintenance; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; nuclear hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; thyroid hormone receptor binding;
MED1	17	nucleoplasm; nucleus; receptor activity; transcription coactivator activity; transcription cofactor activity; RNA polymerase II transcription cofactor activity; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; nuclear hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; thyroid hormone receptor binding;
MED13	17	nucleoplasm; nucleus; receptor activity; transcription coactivator activity; transcription cofactor activity; RNA polymerase II transcription cofactor activity; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; nuclear hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; thyroid hormone receptor binding;
MED24	16	nucleoplasm; nucleus; receptor activity; transcription cofactor activity; RNA polymerase II transcription cofactor activity; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; stem cell maintenance; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; nuclear hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding;
MED30	16	nucleoplasm; nucleus; receptor activity; transcription cofactor activity; RNA polymerase II transcription cofactor activity; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; stem cell maintenance; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; nuclear hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding;
MED16	15	nucleoplasm; nucleus; receptor activity; transcription coactivator activity; transcription cofactor activity; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; nuclear hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding;
MED4	15	nucleoplasm; nucleus; receptor activity; transcription cofactor activity; RNA polymerase II transcription cofactor activity; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; nuclear hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding;
THRAP3	15	nucleus; receptor activity; transcription coactivator activity; transcription cofactor activity; RNA polymerase II transcription cofactor activity; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; transcription initiation from RNA polymerase II promoter; nuclear hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; thyroid hormone receptor binding;
NCOA6	10	transcription factor complex; nucleoplasm; nucleus; transcription coactivator activity; ligand-dependent nuclear receptor transcription coactivator activity; transcription initiation from RNA polymerase II promoter; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; thyroid hormone receptor binding;
MED7	9	transcription factor complex; nucleoplasm; transcription coactivator activity; RNA polymerase II transcription cofactor activity; stem cell maintenance; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter;
SNW1	9	nucleoplasm; nucleus; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; nuclear hormone receptor binding; vitamin D receptor binding; positive regulation of transcription from RNA polymerase II promoter;
MED23	7	transcription factor complex; nucleoplasm; transcription coactivator activity; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter;
YAP1	7	transcription factor complex; nucleoplasm; nucleus; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
MED15	7	nucleoplasm; nucleus; RNA polymerase II transcription cofactor activity; stem cell maintenance; mediator complex; gene expression; transcription initiation from RNA polymerase II promoter;
SMARCD3	7	nucleoplasm; nucleus; transcription coactivator activity; ligand-dependent nuclear receptor transcription coactivator activity; regulation of transcription from RNA polymerase II promoter; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent;
HMGA1	6	transcription factor complex; nucleoplasm; nucleus; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent;
KAT5	6	transcription factor complex; nucleus; transcription coactivator activity; androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
KDM1A	6	transcription factor complex; nucleoplasm; nucleus; ligand-dependent nuclear receptor transcription coactivator activity; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
NCOR1	6	transcription factor complex; nucleoplasm; nucleus; gene expression; transcription initiation from RNA polymerase II promoter; thyroid hormone receptor binding;
RBM14	6	transcription factor complex; nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; positive regulation of transcription from RNA polymerase II promoter;
MAML1	6	nucleoplasm; nucleus; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
MAML2	6	nucleoplasm; nucleus; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
NR5A1	6	nucleoplasm; nucleus; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
PRPF6	6	nucleoplasm; nucleus; transcription coactivator activity; gene expression; nuclear hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter;
NRIP1	6	nucleus; transcription coactivator activity; androgen receptor signaling pathway; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
PPARGC1B	6	nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; nuclear hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter;
E2F5	5	transcription factor complex; nucleoplasm; gene expression; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
NR4A3	5	transcription factor complex; nucleoplasm; nucleus; gene expression; transcription initiation from RNA polymerase II promoter;
RELA	5	transcription factor complex; nucleoplasm; nucleus; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
ESRRA	5	nucleoplasm; nucleus; gene expression; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
MEN1	5	nucleoplasm; nucleus; gene expression; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
NR4A2	5	nucleoplasm; nucleus; gene expression; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
RAN	5	nucleoplasm; transcription coactivator activity; androgen receptor signaling pathway; gene expression; positive regulation of transcription, DNA-dependent;
RBPJ	5	nucleoplasm; nucleus; gene expression; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
SMARCB1	5	nucleoplasm; nucleus; transcription coactivator activity; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
TAF10	5	nucleoplasm; nucleus; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter;
TP53BP1	5	nucleoplasm; nucleus; RNA polymerase II transcription cofactor activity; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
NSD1	5	nucleus; transcription cofactor activity; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding;

Genes shared at least 2 KEGG pathways with MED17 (count: 0)

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Region: chr11:93517393..93547861 View in gBrowse