ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MED17
Previous Symbol	CRSP6
Symbol Alias	CRSP77, TRAP80, DRIP80
Approved Name	mediator complex subunit 17
Previous Name	"cofactor required for Sp1 transcriptional activation, subunit 6 (77kD)", "cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa"
Location	11q21
Position	chr11:93517393-93547861, 1
External Links	HGNC: 2375 Entrez Gene: 9440 Ensembl: ENSG00000042429 UCSC: uc001pem.4
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region; Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	IDA[12218053]; TAS	44
GO:0001104	RNA polymerase II transcription cofactor activity	molecular function	IDA[10198638]	18
GO:0046966	thyroid hormone receptor binding	molecular function	IDA[10198638]	17
GO:0005667	transcription factor complex	cellular component	IDA[9989412]	52
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	molecular function	NAS[10235266]	18
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0003712	transcription cofactor activity	molecular function	IDA[12218053]	18
GO:0010467	gene expression	biological process	TAS	154
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	IDA[9989412]	46
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[12037571]	141
GO:0030518	intracellular steroid hormone receptor signaling pathway	biological process	IDA[11867769]	10
GO:0004872	receptor activity	molecular function	IDA[12218053]	38
GO:0016592	mediator complex	cellular component	IDA[14638676]	20
GO:0019827	stem cell maintenance	biological process	IEA	14
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	IDA[10198638]	89
GO:0030521	androgen receptor signaling pathway	biological process	IDA[12218053]	16
GO:0003713	transcription coactivator activity	molecular function	IDA[12037571]	58
GO:0005634	nucleus	cellular component	IDA[10235267]	877
GO:0042809	vitamin D receptor binding	molecular function	NAS[10235266]	11

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MED17 (count: 39)

Gene Symbol	Pathway Count	Pathway List
MED14	18	transcription initiation from RNA polymerase II promoter; RNA polymerase II transcription cofactor activity; thyroid hormone receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; transcription cofactor activity; gene expression; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; intracellular steroid hormone receptor signaling pathway; receptor activity; mediator complex; stem cell maintenance; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; transcription coactivator activity; nucleus; vitamin D receptor binding;
MED12	17	transcription initiation from RNA polymerase II promoter; RNA polymerase II transcription cofactor activity; thyroid hormone receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; transcription cofactor activity; gene expression; positive regulation of transcription from RNA polymerase II promoter; intracellular steroid hormone receptor signaling pathway; receptor activity; mediator complex; stem cell maintenance; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; transcription coactivator activity; nucleus; vitamin D receptor binding;
MED1	16	transcription initiation from RNA polymerase II promoter; RNA polymerase II transcription cofactor activity; thyroid hormone receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; transcription cofactor activity; gene expression; positive regulation of transcription from RNA polymerase II promoter; intracellular steroid hormone receptor signaling pathway; receptor activity; mediator complex; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; transcription coactivator activity; nucleus; vitamin D receptor binding;
MED13	16	transcription initiation from RNA polymerase II promoter; RNA polymerase II transcription cofactor activity; thyroid hormone receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; transcription cofactor activity; gene expression; positive regulation of transcription from RNA polymerase II promoter; intracellular steroid hormone receptor signaling pathway; receptor activity; mediator complex; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; transcription coactivator activity; nucleus; vitamin D receptor binding;
MED24	15	transcription initiation from RNA polymerase II promoter; RNA polymerase II transcription cofactor activity; thyroid hormone receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; transcription cofactor activity; gene expression; intracellular steroid hormone receptor signaling pathway; receptor activity; mediator complex; stem cell maintenance; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; nucleus; vitamin D receptor binding;
MED30	15	transcription initiation from RNA polymerase II promoter; RNA polymerase II transcription cofactor activity; thyroid hormone receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; transcription cofactor activity; gene expression; intracellular steroid hormone receptor signaling pathway; receptor activity; mediator complex; stem cell maintenance; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; nucleus; vitamin D receptor binding;
MED16	14	transcription initiation from RNA polymerase II promoter; thyroid hormone receptor binding; nucleoplasm; transcription cofactor activity; gene expression; regulation of transcription from RNA polymerase II promoter; intracellular steroid hormone receptor signaling pathway; receptor activity; mediator complex; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; transcription coactivator activity; nucleus; vitamin D receptor binding;
THRAP3	14	transcription initiation from RNA polymerase II promoter; RNA polymerase II transcription cofactor activity; thyroid hormone receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; transcription cofactor activity; positive regulation of transcription from RNA polymerase II promoter; intracellular steroid hormone receptor signaling pathway; receptor activity; mediator complex; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; transcription coactivator activity; nucleus; vitamin D receptor binding;
MED4	14	transcription initiation from RNA polymerase II promoter; RNA polymerase II transcription cofactor activity; thyroid hormone receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; transcription cofactor activity; gene expression; intracellular steroid hormone receptor signaling pathway; receptor activity; mediator complex; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; nucleus; vitamin D receptor binding;
NCOA6	9	transcription initiation from RNA polymerase II promoter; thyroid hormone receptor binding; transcription factor complex; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription coactivator activity; nucleus;
MED27	9	transcription initiation from RNA polymerase II promoter; transcription factor complex; nucleoplasm; gene expression; regulation of transcription from RNA polymerase II promoter; mediator complex; stem cell maintenance; transcription coactivator activity; nucleus;
MED7	9	transcription initiation from RNA polymerase II promoter; RNA polymerase II transcription cofactor activity; transcription factor complex; nucleoplasm; gene expression; regulation of transcription from RNA polymerase II promoter; mediator complex; stem cell maintenance; transcription coactivator activity;
SNW1	8	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus; vitamin D receptor binding;
MED15	7	transcription initiation from RNA polymerase II promoter; RNA polymerase II transcription cofactor activity; nucleoplasm; gene expression; mediator complex; stem cell maintenance; nucleus;
MED10	7	transcription initiation from RNA polymerase II promoter; RNA polymerase II transcription cofactor activity; nucleoplasm; gene expression; positive regulation of transcription from RNA polymerase II promoter; mediator complex; stem cell maintenance;
CREBBP	7	transcription initiation from RNA polymerase II promoter; transcription factor complex; nucleoplasm; gene expression; positive regulation of transcription, DNA-dependent; transcription coactivator activity; nucleus;
MED23	7	transcription initiation from RNA polymerase II promoter; transcription factor complex; nucleoplasm; gene expression; regulation of transcription from RNA polymerase II promoter; mediator complex; transcription coactivator activity;
YAP1	7	transcription initiation from RNA polymerase II promoter; transcription factor complex; nucleoplasm; gene expression; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus;
MAML1	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus;
MAML2	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus;
NR5A1	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus;
MED20	6	transcription initiation from RNA polymerase II promoter; RNA polymerase II transcription cofactor activity; nucleoplasm; gene expression; regulation of transcription from RNA polymerase II promoter; mediator complex;
RBM14	6	RNA polymerase II transcription cofactor activity; transcription factor complex; ligand-dependent nuclear receptor transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; mediator complex; nucleus;
KDM1A	6	transcription factor complex; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; nucleus;
KAT5	6	transcription factor complex; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; transcription coactivator activity; nucleus;
SMARCD3	6	ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription coactivator activity; nucleus;
NR4A2	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleus;
MEN1	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleus;
ESRRA	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleus;
RBPJ	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleus;
TAF10	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; transcription coactivator activity; nucleus;
PPARGC1B	5	RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; mediator complex; nucleus;
TP53BP1	5	RNA polymerase II transcription cofactor activity; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus;
RELA	5	transcription factor complex; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus;
HMGA1	5	transcription factor complex; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; positive regulation of transcription, DNA-dependent; nucleus;
RAN	5	nucleoplasm; gene expression; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; transcription coactivator activity;
SMARCB1	5	nucleoplasm; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus;
PRPF6	5	nucleoplasm; gene expression; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus;
NRIP1	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; transcription coactivator activity; nucleus;

Genes shared at least 2 KEGG pathways with MED17 (count: 0)

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Region: chr11:93517393..93547861 View in gBrowse