ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MED15
Previous Symbol	TNRC7, PCQAP
Symbol Alias	TIG-1, CAG7A, Arc105
Approved Name	mediator complex subunit 15
Previous Name	"trinucleotide repeat containing 7", "PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein"
Location	22q11.2
Position	chr22:20850200-20941919, 1
External Links	HGNC: 14248 Entrez Gene: 51586 Ensembl: ENSG00000099917 UCSC: uc002zsp.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 3)

ID	Location	Size	Band	Type
CNV_Jarick[2012]_41	chr22:17616020-19792353 (NCBI36 / hg18)	2176334	22q11.21	dup
CNV_Jarick[2012]_42	chr22:19066315-19792353 (NCBI36 / hg18)	726039	22q11.21	dup
CNV_Jarick[2012]_40	chr22:17257787-19792353 (NCBI36 / hg18)	2534567	22q11.21	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 9)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0019827	stem cell maintenance	biological process	IEA	14
GO:0010467	gene expression	biological process	TAS	154
GO:0005634	nucleus	cellular component	IDA	877
GO:0005794	Golgi apparatus	cellular component	IDA	174
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0005515	protein binding	molecular function	IPI[16799563]	1015
GO:0001104	RNA polymerase II transcription cofactor activity	molecular function	IEA	18
GO:0016592	mediator complex	cellular component	IEA	20
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	TAS	44

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MED15 (count: 32)

Gene Symbol	Pathway Count	Pathway List
MED30	8	stem cell maintenance; gene expression; nucleus; nucleoplasm; protein binding; RNA polymerase II transcription cofactor activity; mediator complex; transcription initiation from RNA polymerase II promoter;
MED7	7	stem cell maintenance; gene expression; nucleoplasm; protein binding; RNA polymerase II transcription cofactor activity; mediator complex; transcription initiation from RNA polymerase II promoter;
MED24	7	stem cell maintenance; gene expression; nucleus; nucleoplasm; RNA polymerase II transcription cofactor activity; mediator complex; transcription initiation from RNA polymerase II promoter;
MED12	7	stem cell maintenance; gene expression; nucleus; nucleoplasm; RNA polymerase II transcription cofactor activity; mediator complex; transcription initiation from RNA polymerase II promoter;
MED17	7	stem cell maintenance; gene expression; nucleus; nucleoplasm; RNA polymerase II transcription cofactor activity; mediator complex; transcription initiation from RNA polymerase II promoter;
MED14	7	stem cell maintenance; gene expression; nucleus; nucleoplasm; RNA polymerase II transcription cofactor activity; mediator complex; transcription initiation from RNA polymerase II promoter;
MED1	7	gene expression; nucleus; nucleoplasm; protein binding; RNA polymerase II transcription cofactor activity; mediator complex; transcription initiation from RNA polymerase II promoter;
MED4	7	gene expression; nucleus; nucleoplasm; protein binding; RNA polymerase II transcription cofactor activity; mediator complex; transcription initiation from RNA polymerase II promoter;
MED27	6	stem cell maintenance; gene expression; nucleus; nucleoplasm; mediator complex; transcription initiation from RNA polymerase II promoter;
MED10	6	stem cell maintenance; gene expression; nucleoplasm; RNA polymerase II transcription cofactor activity; mediator complex; transcription initiation from RNA polymerase II promoter;
MED13	6	gene expression; nucleus; nucleoplasm; RNA polymerase II transcription cofactor activity; mediator complex; transcription initiation from RNA polymerase II promoter;
MED20	6	gene expression; nucleoplasm; protein binding; RNA polymerase II transcription cofactor activity; mediator complex; transcription initiation from RNA polymerase II promoter;
SMC1A	5	stem cell maintenance; gene expression; nucleus; nucleoplasm; protein binding;
TAF10	5	gene expression; nucleus; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
CREBBP	5	gene expression; nucleus; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
PGR	5	gene expression; nucleus; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
MED16	5	gene expression; nucleus; nucleoplasm; mediator complex; transcription initiation from RNA polymerase II promoter;
MAML2	5	gene expression; nucleus; Golgi apparatus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
NR4A2	5	gene expression; nucleus; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
TAF13	5	gene expression; nucleus; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
YAP1	5	gene expression; nucleus; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
NEDD4L	5	gene expression; nucleus; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
MAML1	5	gene expression; nucleus; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
RBPJ	5	gene expression; nucleus; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
MED23	5	gene expression; nucleoplasm; protein binding; mediator complex; transcription initiation from RNA polymerase II promoter;
ESRRA	5	gene expression; nucleus; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
MEN1	5	gene expression; nucleus; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
NCOR2	5	gene expression; nucleus; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
MAPK3	5	gene expression; nucleus; Golgi apparatus; nucleoplasm; protein binding;
SNW1	5	gene expression; nucleus; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
NR5A1	5	gene expression; nucleus; nucleoplasm; protein binding; transcription initiation from RNA polymerase II promoter;
THRAP3	5	nucleus; protein binding; RNA polymerase II transcription cofactor activity; mediator complex; transcription initiation from RNA polymerase II promoter;

Genes shared at least 2 KEGG pathways with MED15 (count: 0)

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Region: chr22:20850200..20941919 View in gBrowse