ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MED15
Previous Symbol	TNRC7, PCQAP
Symbol Alias	TIG-1, CAG7A, Arc105
Approved Name	mediator complex subunit 15
Previous Name	trinucleotide repeat containing 7, "PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein"
Location	22q11.2
Position	chr22:20850200-20941919, +
External Links	HGNC: 14248 Entrez Gene: 51586 Ensembl: ENSG00000099917 UCSC: uc002zsq.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 3)

ID	Location	Size	Band	Type
CNV_Jarick[2012]_41	chr22:17616020-19792353 (NCBI36 / hg18)	2176334	22q11.21	dup
CNV_Jarick[2012]_42	chr22:19066315-19792353 (NCBI36 / hg18)	726039	22q11.21	dup
CNV_Jarick[2012]_40	chr22:17257787-19792353 (NCBI36 / hg18)	2534567	22q11.21	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 9)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001104	RNA polymerase II transcription cofactor activity	Molecular Function		16
GO:0010467	gene expression	Biological Process		140
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process		42
GO:0019827	stem cell maintenance	Biological Process		12
GO:0016592	mediator complex	Cellular Component		17
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[16799563]	910
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005654	nucleoplasm	Cellular Component		183

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MED15 (count: 29)

Gene Symbol	Pathway Count	Pathway List
MED30	8	RNA polymerase II transcription cofactor activity; gene expression; transcription initiation from RNA polymerase II promoter; stem cell maintenance; mediator complex; nucleus; protein binding; nucleoplasm;
MED1	7	RNA polymerase II transcription cofactor activity; gene expression; transcription initiation from RNA polymerase II promoter; mediator complex; nucleus; protein binding; nucleoplasm;
MED12	7	RNA polymerase II transcription cofactor activity; gene expression; transcription initiation from RNA polymerase II promoter; stem cell maintenance; mediator complex; nucleus; nucleoplasm;
MED14	7	RNA polymerase II transcription cofactor activity; gene expression; transcription initiation from RNA polymerase II promoter; stem cell maintenance; mediator complex; nucleus; nucleoplasm;
MED17	7	RNA polymerase II transcription cofactor activity; gene expression; transcription initiation from RNA polymerase II promoter; stem cell maintenance; mediator complex; nucleus; nucleoplasm;
MED24	7	RNA polymerase II transcription cofactor activity; gene expression; transcription initiation from RNA polymerase II promoter; stem cell maintenance; mediator complex; nucleus; nucleoplasm;
MED4	7	RNA polymerase II transcription cofactor activity; gene expression; transcription initiation from RNA polymerase II promoter; mediator complex; nucleus; protein binding; nucleoplasm;
MED7	7	RNA polymerase II transcription cofactor activity; gene expression; transcription initiation from RNA polymerase II promoter; stem cell maintenance; mediator complex; protein binding; nucleoplasm;
MED13	6	RNA polymerase II transcription cofactor activity; gene expression; transcription initiation from RNA polymerase II promoter; mediator complex; nucleus; nucleoplasm;
THRAP3	5	RNA polymerase II transcription cofactor activity; transcription initiation from RNA polymerase II promoter; mediator complex; nucleus; protein binding;
ESRRA	5	gene expression; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; nucleoplasm;
MAML1	5	gene expression; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; nucleoplasm;
MAML2	5	gene expression; transcription initiation from RNA polymerase II promoter; nucleus; Golgi apparatus; nucleoplasm;
MAPK3	5	gene expression; nucleus; protein binding; Golgi apparatus; nucleoplasm;
MED16	5	gene expression; transcription initiation from RNA polymerase II promoter; mediator complex; nucleus; nucleoplasm;
MED23	5	gene expression; transcription initiation from RNA polymerase II promoter; mediator complex; protein binding; nucleoplasm;
MEN1	5	gene expression; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; nucleoplasm;
NCOR1	5	gene expression; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; nucleoplasm;
NCOR2	5	gene expression; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; nucleoplasm;
NEDD4L	5	gene expression; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; nucleoplasm;
NR4A2	5	gene expression; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; nucleoplasm;
NR5A1	5	gene expression; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; nucleoplasm;
PGR	5	gene expression; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; nucleoplasm;
RBPJ	5	gene expression; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; nucleoplasm;
SMC1A	5	gene expression; stem cell maintenance; nucleus; protein binding; nucleoplasm;
SNW1	5	gene expression; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; nucleoplasm;
TAF10	5	gene expression; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; nucleoplasm;
TAF13	5	gene expression; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; nucleoplasm;
YAP1	5	gene expression; transcription initiation from RNA polymerase II promoter; nucleus; protein binding; nucleoplasm;

Genes shared at least 2 KEGG pathways with MED15 (count: 0)

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Region: chr22:20850200..20941919 View in gBrowse