ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MED24
Previous Symbol	THRAP4, CRSP4
Symbol Alias	TRAP100, KIAA0130, DRIP100, CRSP100
Approved Name	mediator complex subunit 24
Previous Name	thyroid hormone receptor associated protein 4, "cofactor required for Sp1 transcriptional activation, subunit 4, 100kDa"
Location	17q21.2
Position	chr17:38175350-38210889, -
External Links	HGNC: 22963 Entrez Gene: 9862 Ensembl: ENSG00000008838 UCSC: uc002htt.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001104	RNA polymerase II transcription cofactor activity	Molecular Function	IDA[10198638]	16
GO:0004402	histone acetyltransferase activity	Molecular Function		9
GO:0003712	transcription cofactor activity	Molecular Function	IDA[12218053]	17
GO:0005634	nucleus	Cellular Component	IDA[10235267]	770
GO:0004872	receptor activity	Molecular Function	IDA[12218053]	36
GO:0006355	regulation of transcription, DNA-dependent	Biological Process		158
GO:0005654	nucleoplasm	Cellular Component		183
GO:0010467	gene expression	Biological Process		140
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	IDA[12218053]	42
GO:0019827	stem cell maintenance	Biological Process		12
GO:0016592	mediator complex	Cellular Component	NAS[9653119]	17
GO:0030518	intracellular steroid hormone receptor signaling pathway	Biological Process	IDA[11867769]	10
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Molecular Function	NAS[10235266]	19
GO:0030521	androgen receptor signaling pathway	Biological Process	IDA[12218053]	16
GO:0046966	thyroid hormone receptor binding	Molecular Function	IDA[10198638]	18
GO:0051291	protein heterooligomerization	Biological Process		10
GO:0042809	vitamin D receptor binding	Molecular Function	NAS[10235266]	11
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[10198638]	80

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MED24 (count: 21)

Gene Symbol	Pathway Count	Pathway List
MED12	16	RNA polymerase II transcription cofactor activity; transcription cofactor activity; nucleus; receptor activity; nucleoplasm; gene expression; transcription initiation from RNA polymerase II promoter; stem cell maintenance; mediator complex; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent;
MED14	16	RNA polymerase II transcription cofactor activity; transcription cofactor activity; nucleus; receptor activity; nucleoplasm; gene expression; transcription initiation from RNA polymerase II promoter; stem cell maintenance; mediator complex; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent;
MED17	16	RNA polymerase II transcription cofactor activity; transcription cofactor activity; nucleus; receptor activity; nucleoplasm; gene expression; transcription initiation from RNA polymerase II promoter; stem cell maintenance; mediator complex; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent;
MED30	16	RNA polymerase II transcription cofactor activity; transcription cofactor activity; nucleus; receptor activity; nucleoplasm; gene expression; transcription initiation from RNA polymerase II promoter; stem cell maintenance; mediator complex; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent;
MED1	15	RNA polymerase II transcription cofactor activity; transcription cofactor activity; nucleus; receptor activity; nucleoplasm; gene expression; transcription initiation from RNA polymerase II promoter; mediator complex; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent;
MED13	15	RNA polymerase II transcription cofactor activity; transcription cofactor activity; nucleus; receptor activity; nucleoplasm; gene expression; transcription initiation from RNA polymerase II promoter; mediator complex; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent;
MED4	15	RNA polymerase II transcription cofactor activity; transcription cofactor activity; nucleus; receptor activity; nucleoplasm; gene expression; transcription initiation from RNA polymerase II promoter; mediator complex; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent;
THRAP3	13	RNA polymerase II transcription cofactor activity; transcription cofactor activity; nucleus; receptor activity; transcription initiation from RNA polymerase II promoter; mediator complex; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent;
MED16	13	transcription cofactor activity; nucleus; receptor activity; nucleoplasm; gene expression; transcription initiation from RNA polymerase II promoter; mediator complex; intracellular steroid hormone receptor signaling pathway; nuclear hormone receptor binding; androgen receptor signaling pathway; thyroid hormone receptor binding; vitamin D receptor binding; positive regulation of transcription, DNA-dependent;
MED15	7	RNA polymerase II transcription cofactor activity; nucleus; nucleoplasm; gene expression; transcription initiation from RNA polymerase II promoter; stem cell maintenance; mediator complex;
NCOA6	7	nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; thyroid hormone receptor binding; positive regulation of transcription, DNA-dependent;
MED7	6	RNA polymerase II transcription cofactor activity; nucleoplasm; gene expression; transcription initiation from RNA polymerase II promoter; stem cell maintenance; mediator complex;
HMGA1	6	nucleus; regulation of transcription, DNA-dependent; nucleoplasm; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent;
SNW1	6	nucleus; nucleoplasm; gene expression; transcription initiation from RNA polymerase II promoter; nuclear hormone receptor binding; vitamin D receptor binding;
PPARGC1B	5	RNA polymerase II transcription cofactor activity; nucleus; mediator complex; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding;
TAF10	5	histone acetyltransferase activity; nucleus; nucleoplasm; gene expression; transcription initiation from RNA polymerase II promoter;
NSD1	5	transcription cofactor activity; nucleus; nuclear hormone receptor binding; thyroid hormone receptor binding; positive regulation of transcription, DNA-dependent;
NCOR1	5	nucleus; nucleoplasm; gene expression; transcription initiation from RNA polymerase II promoter; thyroid hormone receptor binding;
SMARCD3	5	nucleus; nucleoplasm; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent;
TAF4B	5	nucleus; regulation of transcription, DNA-dependent; nucleoplasm; gene expression; transcription initiation from RNA polymerase II promoter;
MED23	5	regulation of transcription, DNA-dependent; nucleoplasm; gene expression; transcription initiation from RNA polymerase II promoter; mediator complex;

Genes shared at least 2 KEGG pathways with MED24 (count: 0)

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Region: chr17:38175350..38210889 View in gBrowse