ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NSD1
Previous Symbol	STO
Symbol Alias	ARA267, FLJ22263, KMT3B
Approved Name	nuclear receptor binding SET domain protein 1
Previous Name	Sotos syndrome
Location	5q35
Position	chr5:176560026-176727216, +
External Links	HGNC: 14234 Entrez Gene: 64324 Ensembl: ENSG00000165671 UCSC: uc003mfr.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 22)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003682	chromatin binding	Molecular Function		48
GO:0001702	gastrulation with mouth forming second	Biological Process		5
GO:0003714	transcription corepressor activity	Molecular Function		29
GO:0003712	transcription cofactor activity	Molecular Function	IDA[11509567]	17
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0016571	histone methylation	Biological Process		1
GO:0010452	histone H3-K36 methylation	Biological Process		1
GO:0030331	estrogen receptor binding	Molecular Function		10
GO:0016922	ligand-dependent nuclear receptor binding	Molecular Function		4
GO:0005694	chromosome	Cellular Component		15
GO:0005634	nucleus	Cellular Component		770
GO:0008270	zinc ion binding	Molecular Function		323
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[11509567]	80
GO:0046965	retinoid X receptor binding	Molecular Function		5
GO:0046966	thyroid hormone receptor binding	Molecular Function		18
GO:0046975	histone methyltransferase activity (H3-K36 specific)	Molecular Function		1
GO:0034770	histone H4-K20 methylation	Biological Process		1
GO:0042799	histone methyltransferase activity (H4-K20 specific)	Molecular Function		2
GO:0042974	retinoic acid receptor binding	Molecular Function		4
GO:0050681	androgen receptor binding	Molecular Function	IDA[11509567]	10

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00310	Lysine degradation	9

Genes shared at least 5 GO terms with NSD1 (count: 28)

Gene Symbol	Pathway Count	Pathway List
MED1	10	chromatin binding; transcription cofactor activity; negative regulation of transcription from RNA polymerase II promoter; estrogen receptor binding; ligand-dependent nuclear receptor binding; nucleus; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; nuclear hormone receptor binding; retinoic acid receptor binding;
NRIP1	9	transcription corepressor activity; negative regulation of transcription from RNA polymerase II promoter; estrogen receptor binding; nucleus; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; retinoid X receptor binding; nuclear hormone receptor binding; androgen receptor binding;
NCOA6	7	chromatin binding; estrogen receptor binding; nucleus; positive regulation of transcription, DNA-dependent; retinoid X receptor binding; thyroid hormone receptor binding; nuclear hormone receptor binding;
NCOR1	7	chromatin binding; transcription corepressor activity; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; retinoid X receptor binding; thyroid hormone receptor binding;
ISL1	6	chromatin binding; negative regulation of transcription from RNA polymerase II promoter; estrogen receptor binding; ligand-dependent nuclear receptor binding; nucleus; zinc ion binding;
MED12	6	chromatin binding; transcription cofactor activity; nucleus; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; nuclear hormone receptor binding;
RNF2	6	chromatin binding; gastrulation with mouth forming second; negative regulation of transcription from RNA polymerase II promoter; nucleus; zinc ion binding; transcription, DNA-dependent;
HMGA1	6	nucleus; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; retinoid X receptor binding; nuclear hormone receptor binding; retinoic acid receptor binding;
HINFP	5	chromatin binding; nucleus; zinc ion binding; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent;
KDM1A	5	chromatin binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; androgen receptor binding;
NCOR2	5	chromatin binding; transcription corepressor activity; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent;
NUP62	5	chromatin binding; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; nuclear hormone receptor binding;
PRKCB	5	chromatin binding; nucleus; zinc ion binding; transcription, DNA-dependent; androgen receptor binding;
TADA2A	5	chromatin binding; transcription cofactor activity; chromosome; nucleus; zinc ion binding;
LHX1	5	gastrulation with mouth forming second; transcription corepressor activity; nucleus; zinc ion binding; positive regulation of transcription, DNA-dependent;
DDX54	5	transcription corepressor activity; estrogen receptor binding; nucleus; transcription, DNA-dependent; nuclear hormone receptor binding;
SNW1	5	transcription corepressor activity; negative regulation of transcription from RNA polymerase II promoter; nucleus; nuclear hormone receptor binding; retinoic acid receptor binding;
MED13	5	transcription cofactor activity; nucleus; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; nuclear hormone receptor binding;
MED14	5	transcription cofactor activity; nucleus; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; nuclear hormone receptor binding;
MED16	5	transcription cofactor activity; nucleus; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; nuclear hormone receptor binding;
MED17	5	transcription cofactor activity; nucleus; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; nuclear hormone receptor binding;
MED24	5	transcription cofactor activity; nucleus; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; nuclear hormone receptor binding;
MED30	5	transcription cofactor activity; nucleus; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; nuclear hormone receptor binding;
MED4	5	transcription cofactor activity; nucleus; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; nuclear hormone receptor binding;
THRAP3	5	transcription cofactor activity; nucleus; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; nuclear hormone receptor binding;
KAT5	5	negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; androgen receptor binding;
MMS19	5	estrogen receptor binding; nucleus; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding;
SMARCD3	5	ligand-dependent nuclear receptor binding; nucleus; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding;

Genes shared at least 2 KEGG pathways with NSD1 (count: 0)

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Region: chr5:176560026..176727216 View in gBrowse