ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NCOA6
Symbol Alias	KIAA0181, RAP250, ASC2, AIB3, PRIP, TRBP, NRC
Approved Name	nuclear receptor coactivator 6
Name Alias	nuclear receptor coactivator RAP250, "activating signal cointegrator-2", "peroxisome proliferator-activated receptor interacting protein"
Location	20q11
Position	chr20:33302578-33413452, -
External Links	HGNC: 15936 Entrez Gene: 23054 Ensembl: ENSG00000198646 UCSC: uc002xaw.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 32)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 31)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	TAS[12519782]	80
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0044255	cellular lipid metabolic process	Biological Process		30
GO:0043231	intracellular membrane-bounded organelle	Cellular Component		62
GO:0042921	glucocorticoid receptor signaling pathway	Biological Process	NAS[11443112]	3
GO:0035097	histone methyltransferase complex	Cellular Component	IDA[17500065]	4
GO:0030520	intracellular estrogen receptor signaling pathway	Biological Process	NAS[11443112]	4
GO:0060716	labyrinthine layer blood vessel development	Biological Process		6
GO:0046966	thyroid hormone receptor binding	Molecular Function	IDA[11443112]	18
GO:0046965	retinoid X receptor binding	Molecular Function	TAS[11443112]	5
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[11443112]	131
GO:0003682	chromatin binding	Molecular Function		48
GO:0003713	transcription coactivator activity	Molecular Function	IDA[11443112]	52
GO:0005515	protein binding	Molecular Function	IPI[17178841]	910
GO:0005634	nucleus	Cellular Component	NAS[10567404]	770
GO:0007420	brain development	Biological Process		33
GO:0006974	response to DNA damage stimulus	Biological Process	IDA[17500065]	37
GO:0009725	response to hormone stimulus	Biological Process	TAS[11443112]	11
GO:0007507	heart development	Biological Process		23
GO:0030099	myeloid cell differentiation	Biological Process	IDA[11302752]	5
GO:0019899	enzyme binding	Molecular Function	IPI[12039952]	47
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Molecular Function	IPI[11443112]	19
GO:0030331	estrogen receptor binding	Molecular Function	TAS[11443112]	10
GO:0005667	transcription factor complex	Cellular Component	TAS[11443112]	51
GO:0005654	nucleoplasm	Cellular Component		183
GO:0006260	DNA replication	Biological Process	NAS[11443112]	27
GO:0005730	nucleolus	Cellular Component		243
GO:0006310	DNA recombination	Biological Process	NAS[11443112]	14
GO:0006281	DNA repair	Biological Process	NAS[11443112]	62
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process		42
GO:0006352	DNA-dependent transcription, initiation	Biological Process	IDA[10567404]	8

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with NCOA6 (count: 106)

Gene Symbol	Pathway Count	Pathway List
MED1	17	positive regulation of transcription, DNA-dependent; small molecule metabolic process; cellular lipid metabolic process; nuclear hormone receptor binding; thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; chromatin binding; transcription coactivator activity; protein binding; nucleus; brain development; ligand-dependent nuclear receptor transcription coactivator activity; estrogen receptor binding; nucleoplasm; DNA replication; nucleolus; transcription initiation from RNA polymerase II promoter;
RBM14	12	glucocorticoid receptor signaling pathway; intracellular estrogen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; response to hormone stimulus; ligand-dependent nuclear receptor transcription coactivator activity; transcription factor complex; DNA replication; nucleolus; DNA recombination; DNA repair;
MED12	11	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; chromatin binding; transcription coactivator activity; nucleus; heart development; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; transcription initiation from RNA polymerase II promoter;
THRAP3	11	positive regulation of transcription, DNA-dependent; intracellular membrane-bounded organelle; nuclear hormone receptor binding; thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; protein binding; nucleus; ligand-dependent nuclear receptor transcription coactivator activity; nucleolus; transcription initiation from RNA polymerase II promoter;
MEN1	11	histone methyltransferase complex; positive regulation of transcription from RNA polymerase II promoter; chromatin binding; protein binding; nucleus; brain development; response to DNA damage stimulus; nucleoplasm; nucleolus; DNA repair; transcription initiation from RNA polymerase II promoter;
MED17	10	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus; ligand-dependent nuclear receptor transcription coactivator activity; transcription factor complex; nucleoplasm; transcription initiation from RNA polymerase II promoter;
NCOR1	10	small molecule metabolic process; cellular lipid metabolic process; thyroid hormone receptor binding; retinoid X receptor binding; chromatin binding; protein binding; nucleus; transcription factor complex; nucleoplasm; transcription initiation from RNA polymerase II promoter;
HINFP	9	positive regulation of transcription, DNA-dependent; chromatin binding; transcription coactivator activity; protein binding; nucleus; enzyme binding; nucleoplasm; nucleolus; DNA repair;
HMGA1	9	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; retinoid X receptor binding; protein binding; nucleus; enzyme binding; ligand-dependent nuclear receptor transcription coactivator activity; transcription factor complex; nucleoplasm;
MED13	9	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; transcription initiation from RNA polymerase II promoter;
MED14	9	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; transcription initiation from RNA polymerase II promoter;
MED4	9	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; thyroid hormone receptor binding; protein binding; nucleus; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; nucleolus; transcription initiation from RNA polymerase II promoter;
MMS19	9	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; transcription coactivator activity; protein binding; nucleus; response to DNA damage stimulus; response to hormone stimulus; estrogen receptor binding; DNA repair;
SMARCD3	9	positive regulation of transcription, DNA-dependent; small molecule metabolic process; cellular lipid metabolic process; nuclear hormone receptor binding; transcription coactivator activity; protein binding; nucleus; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm;
YAP1	9	positive regulation of transcription from RNA polymerase II promoter; chromatin binding; transcription coactivator activity; protein binding; nucleus; response to DNA damage stimulus; transcription factor complex; nucleoplasm; transcription initiation from RNA polymerase II promoter;
MED30	8	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; thyroid hormone receptor binding; protein binding; nucleus; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; transcription initiation from RNA polymerase II promoter;
NRIP1	8	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; retinoid X receptor binding; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; protein binding; nucleus; estrogen receptor binding;
TFAP2A	8	positive regulation of transcription, DNA-dependent; intracellular membrane-bounded organelle; positive regulation of transcription from RNA polymerase II promoter; chromatin binding; transcription coactivator activity; protein binding; nucleus; nucleolus;
NCOR2	8	small molecule metabolic process; cellular lipid metabolic process; chromatin binding; protein binding; nucleus; nucleoplasm; nucleolus; transcription initiation from RNA polymerase II promoter;
MAML1	8	intracellular membrane-bounded organelle; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; protein binding; nucleus; nucleoplasm; nucleolus; transcription initiation from RNA polymerase II promoter;
RAD1	8	intracellular membrane-bounded organelle; protein binding; nucleus; response to DNA damage stimulus; nucleoplasm; DNA replication; nucleolus; DNA repair;
SNW1	8	nuclear hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; protein binding; nucleus; nucleoplasm; nucleolus; transcription initiation from RNA polymerase II promoter;
RBPJ	8	labyrinthine layer blood vessel development; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; nucleoplasm; nucleolus; DNA recombination; transcription initiation from RNA polymerase II promoter;
KDM1A	8	positive regulation of transcription from RNA polymerase II promoter; chromatin binding; protein binding; nucleus; enzyme binding; ligand-dependent nuclear receptor transcription coactivator activity; transcription factor complex; nucleoplasm;
NR5A1	8	positive regulation of transcription from RNA polymerase II promoter; chromatin binding; transcription coactivator activity; protein binding; nucleus; enzyme binding; nucleoplasm; transcription initiation from RNA polymerase II promoter;
TAF10	8	transcription coactivator activity; protein binding; nucleus; enzyme binding; estrogen receptor binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; DNA-dependent transcription, initiation;
RAD9A	8	protein binding; nucleus; response to DNA damage stimulus; enzyme binding; nucleoplasm; DNA replication; nucleolus; DNA repair;
KAT5	7	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; protein binding; nucleus; transcription factor complex; nucleolus;
MAPK1	7	positive regulation of transcription, DNA-dependent; labyrinthine layer blood vessel development; protein binding; nucleus; response to DNA damage stimulus; nucleoplasm; nucleolus;
MED16	7	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; thyroid hormone receptor binding; transcription coactivator activity; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
MED24	7	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; thyroid hormone receptor binding; nucleus; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; transcription initiation from RNA polymerase II promoter;
NSD1	7	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; thyroid hormone receptor binding; retinoid X receptor binding; chromatin binding; nucleus; estrogen receptor binding;
NUP62	7	positive regulation of transcription, DNA-dependent; small molecule metabolic process; intracellular membrane-bounded organelle; nuclear hormone receptor binding; thyroid hormone receptor binding; chromatin binding; protein binding;
RELA	7	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; chromatin binding; protein binding; nucleus; transcription factor complex; nucleoplasm;
TP53BP1	7	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; response to DNA damage stimulus; nucleoplasm; DNA repair;
PGR	7	intracellular membrane-bounded organelle; protein binding; nucleus; enzyme binding; nucleoplasm; nucleolus; transcription initiation from RNA polymerase II promoter;
TRIP12	7	nuclear hormone receptor binding; thyroid hormone receptor binding; protein binding; nucleus; response to DNA damage stimulus; nucleoplasm; DNA repair;
SMC1A	7	chromatin binding; protein binding; nucleus; nucleoplasm; nucleolus; DNA recombination; DNA repair;
SSRP1	7	chromatin binding; protein binding; nucleus; nucleoplasm; DNA replication; nucleolus; DNA repair;
MRE11A	7	protein binding; nucleus; response to DNA damage stimulus; nucleoplasm; nucleolus; DNA recombination; DNA repair;
FOXC2	6	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; response to hormone stimulus; heart development; transcription factor complex;
HNF1B	6	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; transcription factor complex; nucleolus;
IRF7	6	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; response to DNA damage stimulus; nucleoplasm;
RNF20	6	positive regulation of transcription, DNA-dependent; chromatin binding; transcription coactivator activity; protein binding; nucleus; nucleolus;
LPIN1	6	small molecule metabolic process; cellular lipid metabolic process; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus; transcription factor complex;
ATXN1	6	intracellular membrane-bounded organelle; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; nucleoplasm; nucleolus;
PPARGC1B	6	nuclear hormone receptor binding; intracellular estrogen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; nucleus; ligand-dependent nuclear receptor transcription coactivator activity; estrogen receptor binding;
PRPF6	6	nuclear hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; protein binding; nucleus; nucleoplasm;
GATA6	6	positive regulation of transcription from RNA polymerase II promoter; chromatin binding; protein binding; nucleus; transcription factor complex; nucleoplasm;
MAPK3	6	positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; response to DNA damage stimulus; nucleoplasm; nucleolus;
MTA2	6	positive regulation of transcription from RNA polymerase II promoter; chromatin binding; protein binding; nucleus; transcription factor complex; nucleolus;
SMARCB1	6	positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; protein binding; nucleus; nucleoplasm; nucleolus;
ATM	6	protein binding; brain development; response to DNA damage stimulus; heart development; nucleoplasm; DNA repair;
CHEK1	6	protein binding; nucleus; response to DNA damage stimulus; nucleoplasm; DNA replication; DNA repair;
FEN1	6	protein binding; nucleus; nucleoplasm; DNA replication; nucleolus; DNA repair;
H2AFX	6	protein binding; nucleus; response to DNA damage stimulus; enzyme binding; nucleoplasm; DNA repair;
INO80E	6	protein binding; nucleus; DNA replication; nucleolus; DNA recombination; DNA repair;
TAF13	6	protein binding; nucleus; nucleoplasm; nucleolus; transcription initiation from RNA polymerase II promoter; DNA-dependent transcription, initiation;
USP28	6	protein binding; nucleus; response to DNA damage stimulus; nucleoplasm; nucleolus; DNA repair;
XRCC5	6	protein binding; nucleus; nucleoplasm; nucleolus; DNA recombination; DNA repair;
APBB1	5	positive regulation of transcription, DNA-dependent; chromatin binding; protein binding; nucleus; response to DNA damage stimulus;
ETS1	5	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; transcription factor complex;
FOXF1	5	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; heart development; transcription factor complex;
MLL	5	positive regulation of transcription, DNA-dependent; histone methyltransferase complex; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus;
RAN	5	positive regulation of transcription, DNA-dependent; chromatin binding; transcription coactivator activity; protein binding; nucleoplasm;
RSF1	5	positive regulation of transcription, DNA-dependent; protein binding; nucleus; nucleoplasm; DNA-dependent transcription, initiation;
SUPT3H	5	positive regulation of transcription, DNA-dependent; transcription coactivator activity; nucleus; nucleolus; DNA-dependent transcription, initiation;
YWHAH	5	positive regulation of transcription, DNA-dependent; glucocorticoid receptor signaling pathway; nuclear hormone receptor binding; protein binding; enzyme binding;
ACAT1	5	small molecule metabolic process; cellular lipid metabolic process; brain development; response to hormone stimulus; enzyme binding;
APOA1	5	small molecule metabolic process; cellular lipid metabolic process; protein binding; nucleus; enzyme binding;
APOA5	5	small molecule metabolic process; cellular lipid metabolic process; protein binding; response to hormone stimulus; enzyme binding;
CTGF	5	small molecule metabolic process; cellular lipid metabolic process; intracellular membrane-bounded organelle; DNA replication; transcription initiation from RNA polymerase II promoter;
OXCT1	5	small molecule metabolic process; cellular lipid metabolic process; brain development; response to hormone stimulus; heart development;
PSMC3	5	small molecule metabolic process; transcription coactivator activity; protein binding; nucleus; nucleoplasm;
CLOCK	5	intracellular membrane-bounded organelle; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor complex; nucleolus;
DAXX	5	nuclear hormone receptor binding; protein binding; nucleus; enzyme binding; nucleolus;
DDX54	5	nuclear hormone receptor binding; intracellular estrogen receptor signaling pathway; nucleus; estrogen receptor binding; nucleolus;
NCOA7	5	nuclear hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; ligand-dependent nuclear receptor transcription coactivator activity;
AATF	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; response to DNA damage stimulus; nucleolus;
CBFA2T3	5	positive regulation of transcription from RNA polymerase II promoter; chromatin binding; protein binding; nucleoplasm; nucleolus;
E2F5	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; transcription factor complex; nucleoplasm; transcription initiation from RNA polymerase II promoter;
ESRRA	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
FOXG1	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; brain development; transcription factor complex;
FOXP1	5	positive regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus; transcription factor complex; nucleolus;
MAML2	5	positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
NR4A2	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
POU2F3	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; transcription factor complex; nucleolus;
UBB	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleoplasm; DNA repair; transcription initiation from RNA polymerase II promoter;
UBC	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleoplasm; DNA repair; transcription initiation from RNA polymerase II promoter;
UBE3A	5	positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; protein binding; nucleus; brain development;
NIPBL	5	chromatin binding; protein binding; nucleus; brain development; response to DNA damage stimulus;
POLE	5	chromatin binding; nucleus; nucleoplasm; DNA replication; DNA repair;
RCC1	5	chromatin binding; protein binding; nucleus; nucleoplasm; nucleolus;
SMC3	5	chromatin binding; protein binding; nucleus; nucleoplasm; DNA repair;
MED23	5	transcription coactivator activity; protein binding; transcription factor complex; nucleoplasm; transcription initiation from RNA polymerase II promoter;
MED7	5	transcription coactivator activity; protein binding; transcription factor complex; nucleoplasm; transcription initiation from RNA polymerase II promoter;
SUB1	5	transcription coactivator activity; protein binding; nucleus; transcription factor complex; nucleolus;
CCND1	5	protein binding; nucleus; response to DNA damage stimulus; enzyme binding; nucleoplasm;
CHD1L	5	protein binding; nucleus; response to DNA damage stimulus; nucleolus; DNA repair;
ERCC8	5	protein binding; nucleus; response to DNA damage stimulus; nucleoplasm; DNA repair;
IGHMBP2	5	protein binding; nucleus; DNA replication; DNA recombination; DNA repair;
NFRKB	5	protein binding; nucleus; nucleolus; DNA recombination; DNA repair;
POLD3	5	protein binding; nucleus; nucleoplasm; nucleolus; DNA repair;
POLD4	5	protein binding; nucleus; nucleoplasm; DNA replication; DNA repair;
RAD23B	5	protein binding; nucleus; nucleoplasm; nucleolus; DNA repair;
TAF4B	5	nucleus; nucleoplasm; nucleolus; transcription initiation from RNA polymerase II promoter; DNA-dependent transcription, initiation;

Genes shared at least 2 KEGG pathways with NCOA6 (count: 0)

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Region: chr20:33302578..33413452 View in gBrowse