ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FEN1
Previous Symbol	RAD2
Symbol Alias	FEN-1, MF1
Approved Name	flap structure-specific endonuclease 1
Name Alias	"maturation factor-1", "DNase IV"
Location	11q12
Position	chr11:61560109-61564716, 1
External Links	HGNC: 3650 Entrez Gene: 2237 Ensembl: ENSG00000168496 UCSC: uc001nsg.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by Literature SNP; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 6)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs174545	chr11:61569306(Fwd)	3_prime_UTR_variant; downstream_gene_variant; intron_variant	1(0/1/0)

LD-proxies (count: 5)

rs_ID	Location	Functional Annotation
rs695867	chr11:61561288(Fwd)	intron_variant; upstream_gene_variant
rs102275	chr11:61557803(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; upstream_gene_variant
rs4246215	chr11:61564299(Fwd)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; upstream_gene_variant
rs174541	chr11:61565908(Fwd)	downstream_gene_variant; intron_variant
rs174538	chr11:61560081(Fwd)	5_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 30)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0017108	5'-flap endonuclease activity	molecular function	IDA[18995831]; IMP[8621570]	4
GO:0000287	magnesium ion binding	molecular function	IEA	30
GO:0006284	base-excision repair	biological process	TAS	6
GO:0043137	DNA replication, removal of RNA primer	biological process	IDA[18995831]	1
GO:0003690	double-stranded DNA binding	molecular function	TAS[8131753]	17
GO:0008309	double-stranded DNA specific exodeoxyribonuclease activity	molecular function	TAS[8131753]	1
GO:0048015	phosphatidylinositol-mediated signaling	biological process	NAS[15504738]	20
GO:0004523	ribonuclease H activity	molecular function	IDA[7961795]	1
GO:0005515	protein binding	molecular function	IPI[18692475]	1015
GO:0007613	memory	biological process	IEA	18
GO:0004519	endonuclease activity	molecular function	TAS[8131753]	9
GO:0032201	telomere maintenance via semi-conservative replication	biological process	TAS	4
GO:0005634	nucleus	cellular component	IDA	877
GO:0006260	DNA replication	biological process	NAS[15504738]	31
GO:0030145	manganese ion binding	molecular function	IEA	11
GO:0006281	DNA repair	biological process	NAS[15504738]; TAS	70
GO:0000722	telomere maintenance via recombination	biological process	TAS	5
GO:0008409	5'-3' exonuclease activity	molecular function	IDA[7961795]	3
GO:0000278	mitotic cell cycle	biological process	TAS	66
GO:0006302	double-strand break repair	biological process	TAS[8131753]	14
GO:0000723	telomere maintenance	biological process	TAS	11
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0009650	UV protection	biological process	TAS[8007985]	3
GO:0005739	mitochondrion	cellular component	IDA[18995831]	221
GO:0000084	S phase of mitotic cell cycle	biological process	TAS	19
GO:0003677	DNA binding	molecular function	IMP[11986308]	257
GO:0004527	exonuclease activity	molecular function	TAS[9778254]	3
GO:0006271	DNA strand elongation involved in DNA replication	biological process	TAS	6
GO:0005730	nucleolus	cellular component	IEA	271
GO:0003684	damaged DNA binding	molecular function	TAS[8007985]	12

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene
hsa03450	Non-homologous end-joining	4
hsa03410	Base excision repair	6
hsa03030	DNA replication	6

Genes shared at least 5 GO terms with FEN1 (count: 54)

Gene Symbol	Pathway Count	Pathway List
POLD3	13	base-excision repair; protein binding; telomere maintenance via semi-conservative replication; nucleus; DNA repair; telomere maintenance via recombination; mitotic cell cycle; telomere maintenance; nucleoplasm; mitochondrion; S phase of mitotic cell cycle; DNA strand elongation involved in DNA replication; nucleolus;
POLD4	12	base-excision repair; protein binding; telomere maintenance via semi-conservative replication; nucleus; DNA replication; DNA repair; telomere maintenance via recombination; mitotic cell cycle; telomere maintenance; nucleoplasm; S phase of mitotic cell cycle; DNA strand elongation involved in DNA replication;
POLA2	11	telomere maintenance via semi-conservative replication; nucleus; DNA replication; telomere maintenance via recombination; mitotic cell cycle; telomere maintenance; nucleoplasm; S phase of mitotic cell cycle; DNA binding; DNA strand elongation involved in DNA replication; nucleolus;
MRE11A	9	double-stranded DNA binding; protein binding; nucleus; manganese ion binding; DNA repair; double-strand break repair; nucleoplasm; DNA binding; nucleolus;
XRCC5	9	double-stranded DNA binding; protein binding; nucleus; DNA repair; double-strand break repair; telomere maintenance; nucleoplasm; DNA binding; nucleolus;
NTHL1	8	base-excision repair; double-stranded DNA binding; protein binding; endonuclease activity; nucleus; DNA repair; nucleoplasm; mitochondrion;
FAN1	7	5'-flap endonuclease activity; magnesium ion binding; protein binding; nucleus; DNA repair; 5'-3' exonuclease activity; DNA binding;
ERCC4	7	protein binding; nucleus; DNA repair; telomere maintenance; nucleoplasm; UV protection; damaged DNA binding;
SSRP1	7	protein binding; nucleus; DNA replication; DNA repair; nucleoplasm; DNA binding; nucleolus;
CDT1	7	protein binding; nucleus; DNA replication; mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle; DNA binding;
RAD1	7	protein binding; nucleus; DNA replication; DNA repair; nucleoplasm; nucleolus; damaged DNA binding;
H2AFX	7	protein binding; nucleus; DNA repair; double-strand break repair; nucleoplasm; DNA binding; damaged DNA binding;
CDC45	7	protein binding; nucleus; DNA replication; mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle; DNA strand elongation involved in DNA replication;
TDP2	6	magnesium ion binding; protein binding; nucleus; manganese ion binding; double-strand break repair; nucleolus;
MEN1	6	double-stranded DNA binding; protein binding; nucleus; DNA repair; nucleoplasm; nucleolus;
TP53BP1	6	protein binding; nucleus; DNA repair; double-strand break repair; nucleoplasm; damaged DNA binding;
RAD23B	6	protein binding; nucleus; DNA repair; nucleoplasm; nucleolus; damaged DNA binding;
MAPK1	6	protein binding; nucleus; nucleoplasm; mitochondrion; DNA binding; nucleolus;
RAD9A	6	protein binding; nucleus; DNA replication; DNA repair; nucleoplasm; nucleolus;
HINFP	6	protein binding; nucleus; DNA repair; nucleoplasm; DNA binding; nucleolus;
DDB1	6	protein binding; nucleus; DNA repair; nucleoplasm; DNA binding; damaged DNA binding;
SMC1A	6	protein binding; nucleus; DNA repair; mitotic cell cycle; nucleoplasm; nucleolus;
ATM	6	protein binding; DNA repair; double-strand break repair; telomere maintenance; nucleoplasm; DNA binding;
NCOA6	6	protein binding; nucleus; DNA replication; DNA repair; nucleoplasm; nucleolus;
HMGA1	5	base-excision repair; protein binding; nucleus; nucleoplasm; DNA binding;
MPG	5	base-excision repair; protein binding; DNA repair; nucleoplasm; damaged DNA binding;
NR5A1	5	double-stranded DNA binding; protein binding; nucleus; nucleoplasm; DNA binding;
RBPJ	5	protein binding; nucleus; nucleoplasm; DNA binding; nucleolus;
INO80E	5	protein binding; nucleus; DNA replication; DNA repair; nucleolus;
CEP164	5	protein binding; nucleus; DNA repair; mitotic cell cycle; nucleolus;
ATXN1	5	protein binding; nucleus; nucleoplasm; DNA binding; nucleolus;
CCND1	5	protein binding; nucleus; mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle;
USP28	5	protein binding; nucleus; DNA repair; nucleoplasm; nucleolus;
PGR	5	protein binding; nucleus; nucleoplasm; DNA binding; nucleolus;
DHX9	5	protein binding; nucleus; nucleoplasm; DNA binding; nucleolus;
XPA	5	protein binding; nucleus; DNA repair; nucleoplasm; damaged DNA binding;
GINS2	5	protein binding; mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle; DNA strand elongation involved in DNA replication;
TCF25	5	protein binding; nucleus; mitochondrion; DNA binding; nucleolus;
MAPK3	5	protein binding; nucleus; nucleoplasm; mitochondrion; nucleolus;
SMC3	5	protein binding; nucleus; DNA repair; mitotic cell cycle; nucleoplasm;
TAF13	5	protein binding; nucleus; nucleoplasm; DNA binding; nucleolus;
MED1	5	protein binding; nucleus; DNA replication; nucleoplasm; nucleolus;
DDX23	5	protein binding; nucleus; nucleoplasm; mitochondrion; nucleolus;
NUMA1	5	protein binding; nucleus; mitotic cell cycle; nucleoplasm; nucleolus;
PSMC3	5	protein binding; nucleus; mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle;
UBC	5	protein binding; DNA repair; mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle;
FUS	5	protein binding; nucleus; nucleoplasm; DNA binding; nucleolus;
CHD1L	5	protein binding; nucleus; DNA repair; DNA binding; nucleolus;
IGHMBP2	5	protein binding; nucleus; DNA replication; DNA repair; DNA binding;
CHEK1	5	protein binding; nucleus; DNA replication; DNA repair; nucleoplasm;
UBB	5	protein binding; DNA repair; mitotic cell cycle; nucleoplasm; S phase of mitotic cell cycle;
NFRKB	5	protein binding; nucleus; DNA repair; DNA binding; nucleolus;
RBM14	5	protein binding; nucleus; DNA replication; DNA repair; nucleolus;
NCOR2	5	protein binding; nucleus; nucleoplasm; DNA binding; nucleolus;

Genes shared at least 2 KEGG pathways with FEN1 (count: 3)

Gene Symbol	Pathway Count	Pathway List
POLD4	2	Base excision repair; DNA replication;
POLE3	2	Base excision repair; DNA replication;
POLD3	2	Base excision repair; DNA replication;

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Region: chr11:61560109..61564716 View in gBrowse