Gene Report
Basic Info
| Approved Symbol |
FEN1
|
| Previous Symbol |
RAD2 |
| Symbol Alias |
FEN-1, MF1 |
| Approved Name |
flap structure-specific endonuclease 1 |
| Name Alias |
maturation factor-1, "DNase IV" |
| Location |
11q12 |
| Position |
chr11:61560150-61564710, + |
| External Links |
HGNC: 3650
Entrez Gene: 2237
Ensembl: ENSG00000168496
UCSC: uc001nsg.2
|
| No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
| Source |
Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 6)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 30)
Gene related KEGG pathways (count: 3)
| ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
| hsa03450 |
Non-homologous end-joining |
4 |
Nonhomologous end joining (NHEJ) eliminates DNA double-stran......
Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.
More...
|
| hsa03030 |
DNA replication |
7 |
A complex network of interacting proteins and enzymes is req......
A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA.
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|
| hsa03410 |
Base excision repair |
5 |
Base excision repair (BER) is the predominant DNA damage rep......
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
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|
Genes shared at least 5 GO terms with FEN1 (count: 52)
Genes shared at least 2 KEGG pathways with FEN1 (count: 4)
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