Gene Report
Basic Info
Approved Symbol |
XPA
|
Symbol Alias |
XPAC, XP1 |
Approved Name |
xeroderma pigmentosum, complementation group A |
Location |
9q22.3 |
Position |
chr9:100437191-100459691, - |
External Links |
HGNC: 12814
Entrez Gene: 7507
Ensembl: ENSG00000136936
UCSC: uc004axr.3
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 15)
Gene related KEGG pathways (count: 1)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa03420 |
Nucleotide excision repair |
9 |
Nucleotide excision repair (NER) is a mechanism to recognize......
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
More...
|
Genes shared at least 5 GO terms with XPA (count: 13)
Genes shared at least 2 KEGG pathways with XPA (count: 0)
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