ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0046872
Name metal ion binding
Type molecular function
No. of Genes in ADHDgene  200
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 200)

Literature-origin genes (count: 27)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 16q13 1(0/1/0) IEA
NRXN3 neurexin 3 14q31 1(0/1/0) IEA
NLN neurolysin (metallopeptidase M3 family) 5q12.3 1(1/0/0) IEA
DGKH diacylglycerol kinase, eta 13q13.3 2(1/1/0) IEA
FURIN furin (paired basic amino acid cleaving enzyme) 15q26.1 1(0/0/1) IEA
LMAN2L lectin, mannose-binding 2-like 2q11.1 1(1/0/0) IEA
STS steroid sulfatase (microsomal), isozyme S Xp22.32 3(2/1/0) IEA
BMPR1B bone morphogenetic protein receptor, type IB 4q23-q24 1(0/0/1) IEA
NT5DC3 5'-nucleotidase domain containing 3 12q22-q23.1 1(0/0/1) IEA
ITGA11 integrin, alpha 11 15q22.3-q23 1(0/0/1) IEA
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 22q11.1-q11.2 1(0/1/0) IEA
NT5C2 5'-nucleotidase, cytosolic II 10q24.32 1(1/0/0) IEA
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 1p13 1(1/0/0) IEA
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 16q24.1 2(0/1/1) IEA
TNNI3K TNNI3 interacting kinase 1p31.1 1(0/1/0) IEA
MAP2K5 mitogen-activated protein kinase kinase 5 15q22.31 1(1/0/0) IEA
NRXN1 neurexin 1 2p16.3 1(0/1/0) IEA
ARSB arylsulfatase B 5q14.1 1(0/0/1) IEA
PRKD1 protein kinase D1 14q11 1(0/1/0) IEA
ITGA1 integrin, alpha 1 5q11.1 2(0/2/0) IEA
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 3(0/3/0) IEA
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 17p13 1(0/0/1) IEA
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 22q11.22 1(0/0/1) IEA
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 18p11.22-p11.21 1(1/0/0) IEA
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 Xq28 1(0/1/0) IEA
CLYBL citrate lyase beta like 13q32.3 1(0/0/1) IEA
DMRT2 doublesex and mab-3 related transcription factor 2 9p24.3 1(0/0/1) IEA

Genes from other sources Help (count: 173)

Approved Symbol Approved Name Source Evidence[PMID]
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit Mapped by PBA pathway IEA
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa Mapped by significant region IEA
FAHD1 fumarylacetoacetate hydrolase domain containing 1 Mapped by significant region IEA
PNLIP pancreatic lipase Mapped by PBA pathway IEA
ASXL3 additional sex combs like 3 (Drosophila) Mapped by significant region IEA
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 Mapped by CNV IEA
PELO pelota homolog (Drosophila) Mapped by Literature SNP IEA
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1 Mapped by Literature SNP IEA
ACACA acetyl-CoA carboxylase alpha Mapped by CNV IEA
NARFL nuclear prelamin A recognition factor-like Mapped by significant region IEA
THAP6 THAP domain containing 6 Mapped by CNV IEA
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator Mapped by CNV IEA
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit Mapped by PBA pathway IEA
PC pyruvate carboxylase Mapped by significant region IEA
XPA xeroderma pigmentosum, complementation group A Mapped by significant region IEA
HPX hemopexin Mapped by CNV IEA
PAPD7 PAP associated domain containing 7 Mapped by significant region IEA
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) Mapped by significant region; Mapped by PBA pathway IEA
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 Mapped by significant region IEA
ADAT1 adenosine deaminase, tRNA-specific 1 Mapped by significant region IEA
COLEC12 collectin sub-family member 12 Mapped by CNV IEA
TGFBR1 transforming growth factor, beta receptor 1 Mapped by significant region IEA
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) Mapped by CNV IEA
FOLH1B folate hydrolase 1B Mapped by significant region IEA
KDM4E lysine (K)-specific demethylase 4E Mapped by significant region IEA
LMAN1 lectin, mannose-binding, 1 Mapped by LD-proxy; Mapped by significant region; Mapped by PBA pathway IEA
MDP1 magnesium-dependent phosphatase 1 Mapped by significant region IEA
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) Mapped by PBA pathway IEA
USP2 ubiquitin specific peptidase 2 Mapped by significant region IEA
AMDHD2 amidohydrolase domain containing 2 Mapped by significant region IEA
HDDC2 HD domain containing 2 Mapped by significant region IEA
SYT10 synaptotagmin X Mapped by CNV IEA
UNC13C unc-13 homolog C (C. elegans) Mapped by CNV IEA
TNP2 transition protein 2 (during histone to protamine replacement) Mapped by significant region IEA
TGM7 transglutaminase 7 Mapped by LD-proxy IEA
NUBP1 nucleotide binding protein 1 Mapped by significant region IEA
ZNHIT2 zinc finger, HIT-type containing 2 Mapped by significant region IEA
GDE1 glycerophosphodiester phosphodiesterase 1 Mapped by significant region IEA
PTX4 pentraxin 4, long Mapped by significant region IEA
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 Mapped by significant region IEA
ACSM1 acyl-CoA synthetase medium-chain family member 1 Mapped by significant region IEA
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) Mapped by significant region IEA
ACSM2B acyl-CoA synthetase medium-chain family member 2B Mapped by significant region IEA
STEAP2 STEAP family member 2, metalloreductase Mapped by PBA pathway IEA
DROSHA drosha, ribonuclease type III Mapped by significant region IEA
NT5M 5',3'-nucleotidase, mitochondrial Mapped by significant region IEA
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit Mapped by PBA pathway IEA
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Mapped by significant region IEA
ADCY4 adenylate cyclase 4 Mapped by significant region IEA
TPP1 tripeptidyl peptidase I Mapped by CNV IEA
BCO2 beta-carotene oxygenase 2 Mapped by significant region IEA
ACAT1 acetyl-CoA acetyltransferase 1 Mapped by CNV; Mapped by significant region IEA
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit Mapped by Literature SNP; Mapped by PBA pathway IEA
PICK1 protein interacting with PRKCA 1 Mapped by Literature SNP IEA
NUDT8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 Mapped by significant region IEA
BCMO1 beta-carotene 15,15'-monooxygenase 1 Mapped by significant region IEA
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) Mapped by significant region IEA
ZNHIT3 zinc finger, HIT-type containing 3 Mapped by CNV; Mapped by PBA pathway IEA
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 Mapped by significant region IEA
KAT5 K(lysine) acetyltransferase 5 Mapped by significant region IEA
RPL37 ribosomal protein L37 Mapped by significant region IEA
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Mapped by PBA pathway IEA
PON2 paraoxonase 2 Mapped by PBA pathway IEA
ACSM3 acyl-CoA synthetase medium-chain family member 3 Mapped by significant region IEA
GMPR2 guanosine monophosphate reductase 2 Mapped by significant region IEA
CHN2 chimerin 2 Mapped by CNV IEA
FBP2 fructose-1,6-bisphosphatase 2 Mapped by significant region IEA
NME3 NME/NM23 nucleoside diphosphate kinase 3 Mapped by significant region IEA
ACY3 aspartoacylase (aminocyclase) 3 Mapped by significant region IEA
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B Mapped by CNV IEA
UQCRC2 ubiquinol-cytochrome c reductase core protein II Mapped by CNV; Mapped by significant region IEA
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) Mapped by LD-proxy IEA
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase Mapped by significant region IEA
CARNS1 carnosine synthase 1 Mapped by significant region IEA
ALKBH5 alkB, alkylation repair homolog 5 (E. coli) Mapped by significant region IEA
NRXN2 neurexin 2 Mapped by significant region IEA
KDM4D lysine (K)-specific demethylase 4D Mapped by significant region IEA
HDDC3 HD domain containing 3 Mapped by LD-proxy IEA
GALNS galactosamine (N-acetyl)-6-sulfate sulfatase Mapped by significant region IEA
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 Mapped by significant region IEA
RUFY4 RUN and FYVE domain containing 4 Mapped by significant region IEA
PDZD8 PDZ domain containing 8 Mapped by LD-proxy IEA
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa Mapped by significant region IEA
STK32C serine/threonine kinase 32C Mapped by CNV IEA
ATP13A4 ATPase type 13A4 Mapped by CNV IEA
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) Mapped by CNV IEA
ITK IL2-inducible T-cell kinase Mapped by significant region IEA
DAGLA diacylglycerol lipase, alpha Mapped by significant region IEA
B3GAT1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) Mapped by CNV; Mapped by significant region IEA
STAC3 SH3 and cysteine rich domain 3 Mapped by CNV IEA
TGM1 transglutaminase 1 Mapped by significant region IEA
FLYWCH1 FLYWCH-type zinc finger 1 Mapped by significant region IEA
TERT telomerase reverse transcriptase Mapped by significant region IEA
KARS lysyl-tRNA synthetase Mapped by significant region IEA
FBP1 fructose-1,6-bisphosphatase 1 Mapped by significant region IMP[8387495]
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 Mapped by significant region IEA
ADCY2 adenylate cyclase 2 (brain) Mapped by significant region IEA
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase Mapped by CNV IEA
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 Mapped by significant region IEA
TIMP3 TIMP metallopeptidase inhibitor 3 Mapped by Literature SNP IEA
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit Mapped by significant region; Mapped by PBA pathway IEA
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial Mapped by significant region IEA
CRYAB crystallin, alpha B Mapped by significant region IEA
PARN poly(A)-specific ribonuclease Mapped by significant region IEA
HMOX2 heme oxygenase (decycling) 2 Mapped by significant region IEA
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) Mapped by CNV IEA
RPL37AP8 ribosomal protein L37a pseudogene 8 Mapped by significant region IEA
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) Mapped by significant region IEA
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 Mapped by PBA pathway IEA
NT5DC1 5'-nucleotidase domain containing 1 Mapped by significant region IEA
NUBP2 nucleotide binding protein 2 Mapped by significant region IEA
ADAL adenosine deaminase-like Mapped by LD-proxy IEA
ACSM5 acyl-CoA synthetase medium-chain family member 5 Mapped by significant region IEA
CYBA cytochrome b-245, alpha polypeptide Mapped by significant region IEA
ACSM2A acyl-CoA synthetase medium-chain family member 2A Mapped by significant region IEA
THOP1 thimet oligopeptidase 1 Mapped by LD-proxy IEA
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme Mapped by significant region IEA
ENDOD1 endonuclease domain containing 1 Mapped by significant region IEA
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K Mapped by CNV IEA
NUBPL nucleotide binding protein-like Mapped by significant region IEA
CPPED1 calcineurin-like phosphoesterase domain containing 1 Mapped by significant region IEA
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa Mapped by CNV IEA
COL27A1 collagen, type XXVII, alpha 1 Mapped by significant region IEA
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 Mapped by CNV IEA
PPP4C protein phosphatase 4, catalytic subunit Mapped by CNV NAS
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) Mapped by CNV IEA
PDE7B phosphodiesterase 7B Mapped by significant region IEA
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 Mapped by significant region IEA
JMJD1C jumonji domain containing 1C Mapped by PBA pathway IEA
MUS81 MUS81 structure-specific endonuclease subunit Mapped by significant region IEA
DAK dihydroxyacetone kinase 2 homolog (S. cerevisiae) Mapped by significant region IEA
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 Mapped by significant region IEA
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit Mapped by significant region; Mapped by PBA pathway IEA
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 Mapped by significant region IEA
FGD3 FYVE, RhoGEF and PH domain containing 3 Mapped by significant region IEA
CYB561A3 cytochrome b561 family, member A3 Mapped by significant region IEA
PDE4D phosphodiesterase 4D, cAMP-specific Mapped by CNV IEA
SYT9 synaptotagmin IX Mapped by CNV IEA
ARSJ arylsulfatase family, member J Mapped by CNV IEA
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 Mapped by significant region IEA
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 Mapped by CNV IEA
LATS2 large tumor suppressor kinase 2 Mapped by significant region IEA
PPP6C protein phosphatase 6, catalytic subunit Mapped by significant region IEA
COL10A1 collagen, type X, alpha 1 Mapped by significant region IEA
ADCY9 adenylate cyclase 9 Mapped by significant region IEA
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) Mapped by significant region IEA
NTHL1 nth endonuclease III-like 1 (E. coli) Mapped by significant region IEA
IREB2 iron-responsive element binding protein 2 Mapped by LD-proxy IEA
NME4 NME/NM23 nucleoside diphosphate kinase 4 Mapped by significant region IEA
UPB1 ureidopropionase, beta Mapped by CNV IEA
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) Mapped by significant region IEA
CYB5B cytochrome b5 type B (outer mitochondrial membrane) Mapped by CNV IEA
MTL5 metallothionein-like 5, testis-specific (tesmin) Mapped by CNV; Mapped by significant region NAS[10191092]
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit Mapped by significant region IEA
ADCY3 adenylate cyclase 3 Mapped by LD-proxy IEA
PDE2A phosphodiesterase 2A, cGMP-stimulated Mapped by significant region IEA
THAP7 THAP domain containing 7 Mapped by CNV IEA
CHPF chondroitin polymerizing factor Mapped by significant region IEA
SUMF1 sulfatase modifying factor 1 Mapped by CNV IEA
NEK4 NIMA-related kinase 4 Mapped by LD-proxy IEA
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 Mapped by significant region IEA
RPL37A ribosomal protein L37a Mapped by significant region IEA
CNOT6 CCR4-NOT transcription complex, subunit 6 Mapped by CNV IEA
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa Mapped by significant region IEA
KAT8 K(lysine) acetyltransferase 8 Mapped by CNV IEA
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 Mapped by significant region IEA
DGCR8 DGCR8 microprocessor complex subunit Mapped by CNV IEA
PRLR prolactin receptor Mapped by significant region IEA
EYA4 eyes absent homolog 4 (Drosophila) Mapped by significant region IEA
EBF1 early B-cell factor 1 Mapped by significant region IEA
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1 Mapped by LD-proxy IEA
ADK adenosine kinase Mapped by LD-proxy IEA
PTS 6-pyruvoyltetrahydropterin synthase Mapped by significant region IEA