ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DDB1
Symbol Alias	XPE
Approved Name	damage-specific DNA binding protein 1, 127kDa
Previous Name	damage-specific DNA binding protein 1 (127kD)
Location	11q12-q13
Position	chr11:61066919-61100666, -
External Links	HGNC: 2717 Entrez Gene: 1642 Ensembl: ENSG00000167986 UCSC: uc001nrc.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000075	cell cycle checkpoint	Biological Process	IMP[17088560]	21
GO:0000718	nucleotide-excision repair, DNA damage removal	Biological Process		4
GO:0003677	DNA binding	Molecular Function	TAS[8798680]	220
GO:0003684	damaged DNA binding	Molecular Function	TAS[8407967]	10
GO:0006281	DNA repair	Biological Process		62
GO:0006289	nucleotide-excision repair	Biological Process		12
GO:0016055	Wnt receptor signaling pathway	Biological Process		20
GO:0019048	virus-host interaction	Biological Process		54
GO:0005515	protein binding	Molecular Function		910
GO:0005634	nucleus	Cellular Component		770
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005737	cytoplasm	Cellular Component		690
GO:0080008	Cul4-RING ubiquitin ligase complex	Cellular Component	IDA[18381890]	1
GO:0031465	Cul4B-RING ubiquitin ligase complex	Cellular Component	IDA[18794347]	1
GO:0031464	Cul4A-RING ubiquitin ligase complex	Cellular Component		3
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	Biological Process		16
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Biological Process	IDA[11673459]	16

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03420	Nucleotide excision repair	9	Nucleotide excision repair (NER) is a mechanism to recognize...... Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar. More...
hsa04120	Ubiquitin mediated proteolysis	29	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...

Genes shared at least 5 GO terms with DDB1 (count: 48)

Gene Symbol	Pathway Count	Pathway List
RAD23B	9	nucleotide-excision repair, DNA damage removal; damaged DNA binding; DNA repair; nucleotide-excision repair; protein binding; nucleus; nucleoplasm; cytoplasm; proteasomal ubiquitin-dependent protein catabolic process;
XPA	7	nucleotide-excision repair, DNA damage removal; damaged DNA binding; DNA repair; nucleotide-excision repair; protein binding; nucleus; nucleoplasm;
ERCC8	7	DNA repair; nucleotide-excision repair; protein binding; nucleus; nucleoplasm; Cul4A-RING ubiquitin ligase complex; proteasomal ubiquitin-dependent protein catabolic process;
MRE11A	6	cell cycle checkpoint; DNA binding; DNA repair; protein binding; nucleus; nucleoplasm;
PSMC3	6	cell cycle checkpoint; virus-host interaction; protein binding; nucleus; nucleoplasm; cytoplasm;
RAD1	6	cell cycle checkpoint; damaged DNA binding; DNA repair; protein binding; nucleus; nucleoplasm;
RAD9A	6	cell cycle checkpoint; DNA repair; protein binding; nucleus; nucleoplasm; cytoplasm;
SMC1A	6	cell cycle checkpoint; DNA repair; protein binding; nucleus; nucleoplasm; cytoplasm;
FEN1	6	DNA binding; damaged DNA binding; DNA repair; protein binding; nucleus; nucleoplasm;
H2AFX	6	DNA binding; damaged DNA binding; DNA repair; protein binding; nucleus; nucleoplasm;
MAPK1	6	DNA binding; virus-host interaction; protein binding; nucleus; nucleoplasm; cytoplasm;
RELA	6	DNA binding; virus-host interaction; protein binding; nucleus; nucleoplasm; cytoplasm;
SSRP1	6	DNA binding; DNA repair; protein binding; nucleus; nucleoplasm; cytoplasm;
XRCC5	6	DNA binding; DNA repair; protein binding; nucleus; nucleoplasm; cytoplasm;
TP53BP1	6	damaged DNA binding; DNA repair; protein binding; nucleus; nucleoplasm; cytoplasm;
FANCC	6	DNA repair; nucleotide-excision repair; protein binding; nucleus; nucleoplasm; cytoplasm;
TRIP12	6	DNA repair; protein binding; nucleus; nucleoplasm; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
NEDD4L	6	virus-host interaction; protein binding; nucleus; nucleoplasm; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
ATM	5	cell cycle checkpoint; DNA binding; DNA repair; protein binding; nucleoplasm;
CDC45	5	cell cycle checkpoint; protein binding; nucleus; nucleoplasm; cytoplasm;
CHEK1	5	cell cycle checkpoint; DNA repair; protein binding; nucleus; nucleoplasm;
RBBP8	5	cell cycle checkpoint; damaged DNA binding; DNA repair; protein binding; nucleus;
RFWD2	5	cell cycle checkpoint; protein binding; nucleus; nucleoplasm; cytoplasm;
GTF2H3	5	nucleotide-excision repair, DNA damage removal; damaged DNA binding; DNA repair; nucleotide-excision repair; nucleoplasm;
ATXN1	5	DNA binding; protein binding; nucleus; nucleoplasm; cytoplasm;
CHD1L	5	DNA binding; DNA repair; protein binding; nucleus; cytoplasm;
DHX9	5	DNA binding; protein binding; nucleus; nucleoplasm; cytoplasm;
FAN1	5	DNA binding; DNA repair; nucleotide-excision repair; protein binding; nucleus;
FUS	5	DNA binding; protein binding; nucleus; nucleoplasm; cytoplasm;
HINFP	5	DNA binding; DNA repair; protein binding; nucleus; nucleoplasm;
HMGA1	5	DNA binding; virus-host interaction; protein binding; nucleus; nucleoplasm;
IGHMBP2	5	DNA binding; DNA repair; protein binding; nucleus; cytoplasm;
IRF7	5	DNA binding; protein binding; nucleus; nucleoplasm; cytoplasm;
PGR	5	DNA binding; protein binding; nucleus; nucleoplasm; cytoplasm;
POLE	5	DNA binding; DNA repair; nucleotide-excision repair; nucleus; nucleoplasm;
PRPF19	5	DNA binding; DNA repair; protein binding; nucleus; cytoplasm;
RBPJ	5	DNA binding; protein binding; nucleus; nucleoplasm; cytoplasm;
FANCA	5	DNA repair; protein binding; nucleus; nucleoplasm; cytoplasm;
HERC2	5	DNA repair; protein binding; nucleus; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
MEN1	5	DNA repair; protein binding; nucleus; nucleoplasm; cytoplasm;
MMS19	5	DNA repair; nucleotide-excision repair; protein binding; nucleus; cytoplasm;
POLD3	5	DNA repair; nucleotide-excision repair; protein binding; nucleus; nucleoplasm;
POLD4	5	DNA repair; nucleotide-excision repair; protein binding; nucleus; nucleoplasm;
SMC3	5	DNA repair; protein binding; nucleus; nucleoplasm; cytoplasm;
BNIP3	5	virus-host interaction; protein binding; nucleus; nucleoplasm; cytoplasm;
UBE3A	5	virus-host interaction; protein binding; nucleus; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
CRBN	5	protein binding; nucleus; cytoplasm; Cul4A-RING ubiquitin ligase complex; proteasomal ubiquitin-dependent protein catabolic process;
WWP1	5	protein binding; nucleus; cytoplasm; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;

Genes shared at least 2 KEGG pathways with DDB1 (count: 1)

Gene Symbol	Pathway Count	Pathway List
ERCC8	2	Nucleotide excision repair; Ubiquitin mediated proteolysis;

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Region: chr11:61066919..61100666 View in gBrowse