ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DHX9
Previous Symbol	LKP, DDX9
Symbol Alias	RHA
Approved Name	DEAH (Asp-Glu-Ala-His) box polypeptide 9
Previous Name	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9 (RNA helicase A, nuclear DNA helicase II; leukophysin)
Name Alias	NDH II
Location	1q25
Position	chr1:182808439-182857117, +
External Links	HGNC: 2750 Entrez Gene: 1660 Ensembl: ENSG00000135829 UCSC: uc001gpr.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.3	chr1:180300000-185800000	1 (1/0/0)

Gene related GO terms (count: 21)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005813	centrosome	Cellular Component	IDA[17498979]	71
GO:0005634	nucleus	Cellular Component	IDA[17498979]	770
GO:0007623	circadian rhythm	Biological Process		15
GO:0005654	nucleoplasm	Cellular Component		183
GO:0008380	RNA splicing	Biological Process		65
GO:0005730	nucleolus	Cellular Component		243
GO:0010467	gene expression	Biological Process		140
GO:0005737	cytoplasm	Cellular Component	TAS[8690889]	690
GO:0030529	ribonucleoprotein complex	Cellular Component	IDA[18809582]	23
GO:0004003	ATP-dependent DNA helicase activity	Molecular Function	TAS[9111062]	4
GO:0034605	cellular response to heat	Biological Process		4
GO:0004004	ATP-dependent RNA helicase activity	Molecular Function	TAS[9111062]	5
GO:0070934	CRD-mediated mRNA stabilization	Biological Process	IMP[19029303]	1
GO:0005515	protein binding	Molecular Function		910
GO:0070937	CRD-mediated mRNA stability complex	Cellular Component	IDA[19029303]	1
GO:0005524	ATP binding	Molecular Function		228
GO:0001085	RNA polymerase II transcription factor binding	Molecular Function	IPI[17303075]	10
GO:0003677	DNA binding	Molecular Function		220
GO:0003724	RNA helicase activity	Molecular Function	TAS[8690889]	4
GO:0003725	double-stranded RNA binding	Molecular Function		6
GO:0000398	mRNA splicing, via spliceosome	Biological Process		54

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with DHX9 (count: 108)

Gene Symbol	Pathway Count	Pathway List
DDX23	9	nucleus; nucleoplasm; RNA splicing; nucleolus; gene expression; ATP-dependent RNA helicase activity; protein binding; ATP binding; mRNA splicing, via spliceosome;
FUS	9	nucleus; nucleoplasm; RNA splicing; nucleolus; gene expression; cytoplasm; protein binding; DNA binding; mRNA splicing, via spliceosome;
HNRNPA2B1	9	nucleus; nucleoplasm; RNA splicing; nucleolus; gene expression; cytoplasm; ribonucleoprotein complex; protein binding; mRNA splicing, via spliceosome;
SMC1A	9	nucleus; nucleoplasm; RNA splicing; nucleolus; gene expression; cytoplasm; protein binding; ATP binding; mRNA splicing, via spliceosome;
GSK3B	8	centrosome; nucleus; nucleolus; cytoplasm; ribonucleoprotein complex; protein binding; ATP binding; RNA polymerase II transcription factor binding;
EFTUD2	8	nucleus; nucleoplasm; RNA splicing; nucleolus; gene expression; cytoplasm; protein binding; mRNA splicing, via spliceosome;
HNRNPA1	8	nucleus; nucleoplasm; RNA splicing; nucleolus; gene expression; cytoplasm; ribonucleoprotein complex; mRNA splicing, via spliceosome;
HNRNPH1	8	nucleus; nucleoplasm; RNA splicing; nucleolus; gene expression; cytoplasm; protein binding; mRNA splicing, via spliceosome;
NCBP1	8	nucleus; nucleoplasm; RNA splicing; gene expression; ribonucleoprotein complex; protein binding; DNA binding; mRNA splicing, via spliceosome;
SNRNP200	8	nucleus; nucleoplasm; RNA splicing; nucleolus; gene expression; protein binding; ATP binding; mRNA splicing, via spliceosome;
XRCC5	8	nucleus; nucleoplasm; nucleolus; cytoplasm; ATP-dependent DNA helicase activity; protein binding; ATP binding; DNA binding;
CD2BP2	7	nucleus; nucleoplasm; RNA splicing; gene expression; cytoplasm; protein binding; mRNA splicing, via spliceosome;
CHD1L	7	nucleus; nucleolus; cytoplasm; ATP-dependent DNA helicase activity; protein binding; ATP binding; DNA binding;
DGCR8	7	nucleus; nucleoplasm; nucleolus; gene expression; cytoplasm; protein binding; double-stranded RNA binding;
DHX8	7	nucleus; RNA splicing; nucleolus; ATP-dependent RNA helicase activity; protein binding; ATP binding; mRNA splicing, via spliceosome;
HSPA8	7	nucleus; RNA splicing; nucleolus; gene expression; ribonucleoprotein complex; protein binding; ATP binding;
MAPK1	7	nucleus; nucleoplasm; nucleolus; cytoplasm; protein binding; ATP binding; DNA binding;
PGR	7	nucleus; nucleoplasm; nucleolus; gene expression; cytoplasm; protein binding; DNA binding;
PRPF4	7	nucleus; nucleoplasm; RNA splicing; nucleolus; gene expression; protein binding; mRNA splicing, via spliceosome;
RBPJ	7	nucleus; nucleoplasm; nucleolus; gene expression; cytoplasm; protein binding; DNA binding;
SF3A1	7	nucleus; nucleoplasm; RNA splicing; nucleolus; gene expression; protein binding; mRNA splicing, via spliceosome;
SF3A3	7	nucleus; nucleoplasm; RNA splicing; nucleolus; gene expression; protein binding; mRNA splicing, via spliceosome;
SSRP1	7	nucleus; nucleoplasm; nucleolus; gene expression; cytoplasm; protein binding; DNA binding;
U2AF1	7	nucleus; nucleoplasm; RNA splicing; nucleolus; gene expression; protein binding; mRNA splicing, via spliceosome;
RFWD2	6	centrosome; nucleus; nucleoplasm; nucleolus; cytoplasm; protein binding;
ATXN1	6	nucleus; nucleoplasm; nucleolus; cytoplasm; protein binding; DNA binding;
CPSF7	6	nucleus; nucleoplasm; RNA splicing; gene expression; protein binding; mRNA splicing, via spliceosome;
IARS	6	nucleus; nucleolus; gene expression; cytoplasm; protein binding; ATP binding;
IGHMBP2	6	nucleus; cytoplasm; ribonucleoprotein complex; protein binding; ATP binding; DNA binding;
MAPK3	6	nucleus; nucleoplasm; nucleolus; gene expression; protein binding; ATP binding;
MEN1	6	nucleus; nucleoplasm; nucleolus; gene expression; cytoplasm; protein binding;
MRE11A	6	nucleus; nucleoplasm; nucleolus; ATP-dependent DNA helicase activity; protein binding; DNA binding;
NCOR2	6	nucleus; nucleoplasm; nucleolus; gene expression; protein binding; DNA binding;
PRPF6	6	nucleus; nucleoplasm; RNA splicing; gene expression; protein binding; mRNA splicing, via spliceosome;
PSMC3	6	nucleus; nucleoplasm; gene expression; cytoplasm; protein binding; ATP binding;
RBM4	6	nucleus; nucleoplasm; RNA splicing; nucleolus; cytoplasm; protein binding;
SART1	6	nucleus; nucleoplasm; nucleolus; cytoplasm; protein binding; mRNA splicing, via spliceosome;
SF3B2	6	nucleus; nucleoplasm; RNA splicing; nucleolus; gene expression; mRNA splicing, via spliceosome;
SNRPD1	6	nucleus; nucleoplasm; RNA splicing; gene expression; protein binding; mRNA splicing, via spliceosome;
SNW1	6	nucleus; nucleoplasm; nucleolus; gene expression; protein binding; mRNA splicing, via spliceosome;
TAF13	6	nucleus; nucleoplasm; nucleolus; gene expression; protein binding; DNA binding;
TAF4B	6	nucleus; nucleoplasm; nucleolus; gene expression; cytoplasm; DNA binding;
CPSF3	6	nucleoplasm; RNA splicing; gene expression; ribonucleoprotein complex; protein binding; mRNA splicing, via spliceosome;
XPO1	6	nucleoplasm; nucleolus; gene expression; cytoplasm; ribonucleoprotein complex; protein binding;
AATF	5	centrosome; nucleus; nucleolus; cytoplasm; protein binding;
CDC45	5	centrosome; nucleus; nucleoplasm; cytoplasm; protein binding;
CEP164	5	centrosome; nucleus; nucleolus; cytoplasm; protein binding;
CEP57	5	centrosome; nucleus; nucleolus; cytoplasm; protein binding;
CHEK1	5	centrosome; nucleus; nucleoplasm; protein binding; ATP binding;
FLII	5	centrosome; nucleus; nucleolus; cytoplasm; protein binding;
KIF23	5	centrosome; nucleus; nucleoplasm; protein binding; ATP binding;
PAFAH1B1	5	centrosome; nucleus; nucleolus; cytoplasm; protein binding;
PLK1	5	centrosome; nucleus; nucleoplasm; protein binding; ATP binding;
TFAP2A	5	centrosome; nucleus; nucleolus; cytoplasm; protein binding;
TNFAIP3	5	centrosome; nucleus; cytoplasm; protein binding; DNA binding;
ATXN2	5	nucleus; nucleolus; cytoplasm; ribonucleoprotein complex; protein binding;
BCLAF1	5	nucleus; nucleolus; cytoplasm; protein binding; DNA binding;
CDK12	5	nucleus; RNA splicing; nucleolus; protein binding; ATP binding;
DCPS	5	nucleus; nucleolus; gene expression; cytoplasm; protein binding;
DDB1	5	nucleus; nucleoplasm; cytoplasm; protein binding; DNA binding;
DHX15	5	nucleus; RNA splicing; nucleolus; ATP binding; RNA helicase activity;
ESRRA	5	nucleus; nucleoplasm; gene expression; protein binding; DNA binding;
FEN1	5	nucleus; nucleoplasm; nucleolus; protein binding; DNA binding;
HINFP	5	nucleus; nucleoplasm; nucleolus; protein binding; DNA binding;
IRF7	5	nucleus; nucleoplasm; cytoplasm; protein binding; DNA binding;
MAML1	5	nucleus; nucleoplasm; nucleolus; gene expression; protein binding;
MED1	5	nucleus; nucleoplasm; nucleolus; gene expression; protein binding;
MED4	5	nucleus; nucleoplasm; nucleolus; gene expression; protein binding;
NCOR1	5	nucleus; nucleoplasm; gene expression; cytoplasm; protein binding;
NEDD4L	5	nucleus; nucleoplasm; gene expression; cytoplasm; protein binding;
NR4A2	5	nucleus; nucleoplasm; gene expression; cytoplasm; protein binding;
NR5A1	5	nucleus; nucleoplasm; gene expression; protein binding; DNA binding;
NUMA1	5	nucleus; nucleoplasm; nucleolus; cytoplasm; protein binding;
POLA2	5	nucleus; nucleoplasm; nucleolus; cytoplasm; DNA binding;
POLR2G	5	nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome;
PRPF19	5	nucleus; cytoplasm; protein binding; DNA binding; mRNA splicing, via spliceosome;
RAD23B	5	nucleus; nucleoplasm; nucleolus; cytoplasm; protein binding;
RAD9A	5	nucleus; nucleoplasm; nucleolus; cytoplasm; protein binding;
RCC1	5	nucleus; nucleoplasm; nucleolus; cytoplasm; protein binding;
RELA	5	nucleus; nucleoplasm; cytoplasm; protein binding; DNA binding;
RPS3	5	nucleus; gene expression; cytoplasm; ribonucleoprotein complex; protein binding;
RPS6KA4	5	nucleus; nucleolus; cytoplasm; protein binding; ATP binding;
SMC3	5	nucleus; nucleoplasm; cytoplasm; protein binding; ATP binding;
SMG1	5	nucleus; gene expression; cytoplasm; protein binding; ATP binding;
TAF10	5	nucleus; nucleoplasm; gene expression; cytoplasm; protein binding;
TCF25	5	nucleus; nucleolus; cytoplasm; protein binding; DNA binding;
THRAP3	5	nucleus; RNA splicing; nucleolus; protein binding; ATP binding;
YAP1	5	nucleus; nucleoplasm; gene expression; cytoplasm; protein binding;
ZFR	5	nucleus; nucleolus; cytoplasm; protein binding; DNA binding;
CLP1	5	nucleoplasm; RNA splicing; gene expression; ATP binding; mRNA splicing, via spliceosome;
DROSHA	5	nucleoplasm; nucleolus; gene expression; protein binding; double-stranded RNA binding;
E2F5	5	nucleoplasm; gene expression; cytoplasm; protein binding; DNA binding;
HNRNPC	5	nucleoplasm; RNA splicing; gene expression; protein binding; mRNA splicing, via spliceosome;
PHF5A	5	nucleoplasm; RNA splicing; gene expression; DNA binding; mRNA splicing, via spliceosome;
PRPF8	5	nucleoplasm; RNA splicing; gene expression; protein binding; mRNA splicing, via spliceosome;
SF3B4	5	nucleoplasm; RNA splicing; gene expression; protein binding; mRNA splicing, via spliceosome;
SNRPA	5	nucleoplasm; RNA splicing; gene expression; protein binding; mRNA splicing, via spliceosome;
SNRPA1	5	nucleoplasm; RNA splicing; gene expression; protein binding; mRNA splicing, via spliceosome;
SNRPB	5	nucleoplasm; RNA splicing; gene expression; protein binding; mRNA splicing, via spliceosome;
SNRPB2	5	nucleoplasm; RNA splicing; gene expression; protein binding; mRNA splicing, via spliceosome;
SNRPD2	5	nucleoplasm; RNA splicing; gene expression; protein binding; mRNA splicing, via spliceosome;
SNRPD3	5	nucleoplasm; RNA splicing; gene expression; protein binding; mRNA splicing, via spliceosome;
SNRPG	5	nucleoplasm; RNA splicing; gene expression; protein binding; mRNA splicing, via spliceosome;
TXNL4A	5	nucleoplasm; RNA splicing; gene expression; protein binding; mRNA splicing, via spliceosome;
U2AF2	5	nucleoplasm; RNA splicing; gene expression; protein binding; mRNA splicing, via spliceosome;
ZFPM1	5	nucleoplasm; cytoplasm; protein binding; RNA polymerase II transcription factor binding; DNA binding;
OASL	5	nucleolus; cytoplasm; ATP binding; DNA binding; double-stranded RNA binding;
RPS9	5	nucleolus; gene expression; cytoplasm; ribonucleoprotein complex; protein binding;

Genes shared at least 2 KEGG pathways with DHX9 (count: 0)

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Region: chr1:182808439..182857117 View in gBrowse