ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SNRPB
Previous Symbol	SNRPB1
Symbol Alias	COD, SmB/SmB', Sm-B/B', snRNP-B
Approved Name	small nuclear ribonucleoprotein polypeptides B and B1
Location	20p13
Position	chr20:2442280-2451499, -
External Links	HGNC: 11153 Entrez Gene: 6628 Ensembl: ENSG00000125835 UCSC: uc002wfz.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component	TAS[2531083]	51

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0071204	histone pre-mRNA 3'end processing complex	Cellular Component		2
GO:0071208	histone pre-mRNA DCP binding	Molecular Function		2
GO:0034660	ncRNA metabolic process	Biological Process		8
GO:0071013	catalytic step 2 spliceosome	Cellular Component	IDA[11991638]	31
GO:0016070	RNA metabolic process	Biological Process		46
GO:0030532	small nuclear ribonucleoprotein complex	Cellular Component	TAS[2531083]	12
GO:0008380	RNA splicing	Biological Process		65
GO:0010467	gene expression	Biological Process		140
GO:0006397	mRNA processing	Biological Process		50
GO:0008334	histone mRNA metabolic process	Biological Process		6
GO:0006366	transcription from RNA polymerase II promoter	Biological Process		62
GO:0006369	termination of RNA polymerase II transcription	Biological Process		14
GO:0005689	U12-type spliceosomal complex	Cellular Component	IDA[15146077]	16
GO:0005829	cytosol	Cellular Component		447
GO:0005683	U7 snRNP	Cellular Component	IDA[11574479]	5
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005515	protein binding	Molecular Function	IPI[15494309]	910
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[11991638]	54
GO:0000387	spliceosomal snRNP assembly	Biological Process		10

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...
hsa05322	Systemic lupus erythematosus	19	Systemic lupus erythematosus (SLE) is a prototypic autoimmun...... Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components, in association with a diverse array of clinical manifestations. The primary pathological findings in patients with SLE are those of inflammation, vasculitis, immune complex deposition, and vasculopathy. Immune complexes comprising autoantibody and self-antigen is deposited particulary in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc{gamma}R-mediated neutrophil and macrophage activation. Activation of complement (C5) leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases. More...

Genes shared at least 5 GO terms with SNRPB (count: 56)

Gene Symbol	Pathway Count	Pathway List
SNRPD3	19	histone pre-mRNA DCP binding; ncRNA metabolic process; catalytic step 2 spliceosome; RNA metabolic process; small nuclear ribonucleoprotein complex; RNA splicing; gene expression; mRNA processing; histone mRNA metabolic process; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; U12-type spliceosomal complex; cytosol; spliceosomal complex; U7 snRNP; nucleoplasm; protein binding; mRNA splicing, via spliceosome; spliceosomal snRNP assembly;
SNRPG	18	ncRNA metabolic process; catalytic step 2 spliceosome; RNA metabolic process; small nuclear ribonucleoprotein complex; RNA splicing; gene expression; mRNA processing; histone mRNA metabolic process; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; U12-type spliceosomal complex; cytosol; spliceosomal complex; U7 snRNP; nucleoplasm; protein binding; mRNA splicing, via spliceosome; spliceosomal snRNP assembly;
SNRPF	17	ncRNA metabolic process; catalytic step 2 spliceosome; RNA metabolic process; small nuclear ribonucleoprotein complex; RNA splicing; gene expression; mRNA processing; histone mRNA metabolic process; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; U12-type spliceosomal complex; cytosol; spliceosomal complex; U7 snRNP; nucleoplasm; mRNA splicing, via spliceosome; spliceosomal snRNP assembly;
NCBP1	13	ncRNA metabolic process; RNA metabolic process; RNA splicing; gene expression; mRNA processing; histone mRNA metabolic process; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; cytosol; nucleoplasm; protein binding; mRNA splicing, via spliceosome; spliceosomal snRNP assembly;
SNRPD2	13	ncRNA metabolic process; catalytic step 2 spliceosome; RNA metabolic process; small nuclear ribonucleoprotein complex; RNA splicing; gene expression; U12-type spliceosomal complex; cytosol; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome; spliceosomal snRNP assembly;
SNRPD1	12	ncRNA metabolic process; catalytic step 2 spliceosome; RNA metabolic process; small nuclear ribonucleoprotein complex; RNA splicing; gene expression; U12-type spliceosomal complex; cytosol; nucleoplasm; protein binding; mRNA splicing, via spliceosome; spliceosomal snRNP assembly;
U2AF1	10	catalytic step 2 spliceosome; RNA splicing; gene expression; mRNA processing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
LSM11	9	histone pre-mRNA 3'end processing complex; gene expression; mRNA processing; histone mRNA metabolic process; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; U7 snRNP; nucleoplasm; protein binding;
SF3B3	9	catalytic step 2 spliceosome; small nuclear ribonucleoprotein complex; RNA splicing; gene expression; mRNA processing; U12-type spliceosomal complex; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome;
U2AF2	9	RNA splicing; gene expression; mRNA processing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
CDC40	8	catalytic step 2 spliceosome; RNA splicing; gene expression; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome;
EFTUD2	8	catalytic step 2 spliceosome; RNA splicing; gene expression; mRNA processing; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
HNRNPA2B1	8	catalytic step 2 spliceosome; RNA splicing; gene expression; mRNA processing; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
PRPF8	8	catalytic step 2 spliceosome; RNA splicing; gene expression; mRNA processing; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SF3A1	8	catalytic step 2 spliceosome; RNA splicing; gene expression; mRNA processing; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SF3A2	8	catalytic step 2 spliceosome; small nuclear ribonucleoprotein complex; RNA splicing; gene expression; mRNA processing; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome;
SF3A3	8	catalytic step 2 spliceosome; RNA splicing; gene expression; mRNA processing; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SF3B2	8	catalytic step 2 spliceosome; RNA splicing; gene expression; mRNA processing; U12-type spliceosomal complex; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome;
SNRPA1	8	catalytic step 2 spliceosome; small nuclear ribonucleoprotein complex; RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SNRPB2	8	catalytic step 2 spliceosome; RNA splicing; gene expression; mRNA processing; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
LSM4	8	RNA metabolic process; small nuclear ribonucleoprotein complex; RNA splicing; gene expression; mRNA processing; cytosol; spliceosomal complex; protein binding;
CPSF3	8	RNA splicing; gene expression; mRNA processing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
CPSF7	8	RNA splicing; gene expression; mRNA processing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SF3B4	8	RNA splicing; gene expression; mRNA processing; U12-type spliceosomal complex; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
DDX23	7	catalytic step 2 spliceosome; RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
HNRNPA1	7	catalytic step 2 spliceosome; RNA splicing; gene expression; mRNA processing; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome;
HNRNPC	7	catalytic step 2 spliceosome; RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
PRPF6	7	catalytic step 2 spliceosome; RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SNRNP200	7	catalytic step 2 spliceosome; RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
HSPA8	7	RNA metabolic process; RNA splicing; gene expression; mRNA processing; cytosol; spliceosomal complex; protein binding;
CLP1	7	RNA splicing; gene expression; mRNA processing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; nucleoplasm; mRNA splicing, via spliceosome;
PCF11	7	RNA splicing; gene expression; mRNA processing; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; nucleoplasm; mRNA splicing, via spliceosome;
CLNS1A	6	ncRNA metabolic process; RNA metabolic process; gene expression; cytosol; protein binding; spliceosomal snRNP assembly;
HNRNPH1	6	catalytic step 2 spliceosome; RNA splicing; gene expression; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SART1	6	catalytic step 2 spliceosome; cytosol; nucleoplasm; protein binding; mRNA splicing, via spliceosome; spliceosomal snRNP assembly;
SNW1	6	catalytic step 2 spliceosome; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
PHF5A	6	RNA splicing; gene expression; U12-type spliceosomal complex; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome;
PRPF4	6	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SNRPA	6	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
TXNL4A	6	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
DHX8	5	catalytic step 2 spliceosome; RNA splicing; spliceosomal complex; protein binding; mRNA splicing, via spliceosome;
PSMB7	5	RNA metabolic process; gene expression; cytosol; nucleoplasm; protein binding;
PSMC3	5	RNA metabolic process; gene expression; cytosol; nucleoplasm; protein binding;
PSMD5	5	RNA metabolic process; gene expression; cytosol; nucleoplasm; protein binding;
PSMD7	5	RNA metabolic process; gene expression; cytosol; nucleoplasm; protein binding;
UBB	5	RNA metabolic process; gene expression; cytosol; nucleoplasm; protein binding;
UBC	5	RNA metabolic process; gene expression; cytosol; nucleoplasm; protein binding;
XPO1	5	RNA metabolic process; gene expression; cytosol; nucleoplasm; protein binding;
CD2BP2	5	RNA splicing; gene expression; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
DHX9	5	RNA splicing; gene expression; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
FUS	5	RNA splicing; gene expression; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
POLR2G	5	RNA splicing; gene expression; transcription from RNA polymerase II promoter; nucleoplasm; mRNA splicing, via spliceosome;
SMC1A	5	RNA splicing; gene expression; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
ZCRB1	5	RNA splicing; mRNA processing; U12-type spliceosomal complex; spliceosomal complex; nucleoplasm;
ZRSR2	5	RNA splicing; U12-type spliceosomal complex; spliceosomal complex; protein binding; mRNA splicing, via spliceosome;
TCEB1	5	gene expression; transcription from RNA polymerase II promoter; cytosol; nucleoplasm; protein binding;

Genes shared at least 2 KEGG pathways with SNRPB (count: 2)

Gene Symbol	Pathway Count	Pathway List
SNRPD1	2	Spliceosome; Systemic lupus erythematosus;
SNRPD3	2	Spliceosome; Systemic lupus erythematosus;

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Region: chr20:2442280..2451499 View in gBrowse