ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CLP1
Symbol Alias	HEAB, hClp1
Approved Name	CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae)
Name Alias	ATP/GTPbinding protein
Location	11q12
Position	chr11:57416465-57429340, +
External Links	HGNC: 16999 Entrez Gene: 10978 Ensembl: ENSG00000172409 UCSC: uc001nkw.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051736	ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity	Molecular Function	IDA[17495927]	1
GO:0051733	polydeoxyribonucleotide kinase activity	Molecular Function	IDA[17495927]	1
GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity	Molecular Function		1
GO:0000214	tRNA-intron endonuclease complex	Cellular Component	IDA[17495927]	1
GO:0000398	mRNA splicing, via spliceosome	Biological Process		54
GO:0005524	ATP binding	Molecular Function	TAS[8896421]	228
GO:0005654	nucleoplasm	Cellular Component		183
GO:0006366	transcription from RNA polymerase II promoter	Biological Process		62
GO:0006369	termination of RNA polymerase II transcription	Biological Process		14
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	Biological Process	IDA[17495927]	2
GO:0006397	mRNA processing	Biological Process		50
GO:0008380	RNA splicing	Biological Process		65
GO:0010467	gene expression	Biological Process		140
GO:0030423	targeting of mRNA for destruction involved in RNA interference	Biological Process	IMP[17495927]	1
GO:0031124	mRNA 3'-end processing	Biological Process		8
GO:0035087	siRNA loading onto RISC involved in RNA interference	Biological Process	IDA[17495927]	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03015	mRNA surveillance pathway	17	The mRNA surveillance pathway is a quality control mechanism...... The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins. More...

Genes shared at least 5 GO terms with CLP1 (count: 28)

Gene Symbol	Pathway Count	Pathway List
CPSF3	8	mRNA splicing, via spliceosome; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; RNA splicing; gene expression; mRNA 3'-end processing;
CPSF7	8	mRNA splicing, via spliceosome; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; RNA splicing; gene expression; mRNA 3'-end processing;
NCBP1	8	mRNA splicing, via spliceosome; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; RNA splicing; gene expression; mRNA 3'-end processing;
PCF11	8	mRNA splicing, via spliceosome; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; RNA splicing; gene expression; mRNA 3'-end processing;
U2AF1	8	mRNA splicing, via spliceosome; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; RNA splicing; gene expression; mRNA 3'-end processing;
U2AF2	8	mRNA splicing, via spliceosome; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; RNA splicing; gene expression; mRNA 3'-end processing;
CDC40	7	mRNA splicing, via spliceosome; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; RNA splicing; gene expression; mRNA 3'-end processing;
SNRPB	7	mRNA splicing, via spliceosome; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; RNA splicing; gene expression;
SNRPD3	7	mRNA splicing, via spliceosome; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; RNA splicing; gene expression;
SNRPF	7	mRNA splicing, via spliceosome; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; RNA splicing; gene expression;
SNRPG	7	mRNA splicing, via spliceosome; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; RNA splicing; gene expression;
DDX23	5	mRNA splicing, via spliceosome; ATP binding; nucleoplasm; RNA splicing; gene expression;
DHX9	5	mRNA splicing, via spliceosome; ATP binding; nucleoplasm; RNA splicing; gene expression;
EFTUD2	5	mRNA splicing, via spliceosome; nucleoplasm; mRNA processing; RNA splicing; gene expression;
HNRNPA1	5	mRNA splicing, via spliceosome; nucleoplasm; mRNA processing; RNA splicing; gene expression;
HNRNPA2B1	5	mRNA splicing, via spliceosome; nucleoplasm; mRNA processing; RNA splicing; gene expression;
POLR2G	5	mRNA splicing, via spliceosome; nucleoplasm; transcription from RNA polymerase II promoter; RNA splicing; gene expression;
PRPF8	5	mRNA splicing, via spliceosome; nucleoplasm; mRNA processing; RNA splicing; gene expression;
SF3A1	5	mRNA splicing, via spliceosome; nucleoplasm; mRNA processing; RNA splicing; gene expression;
SF3A2	5	mRNA splicing, via spliceosome; nucleoplasm; mRNA processing; RNA splicing; gene expression;
SF3A3	5	mRNA splicing, via spliceosome; nucleoplasm; mRNA processing; RNA splicing; gene expression;
SF3B2	5	mRNA splicing, via spliceosome; nucleoplasm; mRNA processing; RNA splicing; gene expression;
SF3B3	5	mRNA splicing, via spliceosome; nucleoplasm; mRNA processing; RNA splicing; gene expression;
SF3B4	5	mRNA splicing, via spliceosome; nucleoplasm; mRNA processing; RNA splicing; gene expression;
SMC1A	5	mRNA splicing, via spliceosome; ATP binding; nucleoplasm; RNA splicing; gene expression;
SNRNP200	5	mRNA splicing, via spliceosome; ATP binding; nucleoplasm; RNA splicing; gene expression;
SNRPB2	5	mRNA splicing, via spliceosome; nucleoplasm; mRNA processing; RNA splicing; gene expression;
LSM11	5	nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA processing; gene expression;

Genes shared at least 2 KEGG pathways with CLP1 (count: 0)

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Region: chr11:57416465..57429340 View in gBrowse