ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PRPF8
Previous Symbol	RP13
Symbol Alias	PRPC8, Prp8
Approved Name	PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
Previous Name	PRP8 pre-mRNA processing factor 8 homolog (yeast)
Location	17p13.3
Position	chr17:1553923-1588176, -
External Links	HGNC: 17340 Entrez Gene: 10594 Ensembl: ENSG00000174231 UCSC: uc002fte.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component		51

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008380	RNA splicing	Biological Process		65
GO:0003723	RNA binding	Molecular Function		104
GO:0006397	mRNA processing	Biological Process	TAS[9774689]	50
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[11991638]	54
GO:0005682	U5 snRNP	Cellular Component	TAS[9774689]	5
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005515	protein binding	Molecular Function	IPI[9774689]	910
GO:0071013	catalytic step 2 spliceosome	Cellular Component	IDA[11991638]	31
GO:0016607	nuclear speck	Cellular Component		34
GO:0000375	RNA splicing, via transesterification reactions	Biological Process	TAS[9774689]	11
GO:0010467	gene expression	Biological Process		140

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with PRPF8 (count: 49)

Gene Symbol	Pathway Count	Pathway List
PRPF6	11	RNA splicing; RNA binding; mRNA splicing, via spliceosome; U5 snRNP; nucleoplasm; spliceosomal complex; protein binding; catalytic step 2 spliceosome; nuclear speck; RNA splicing, via transesterification reactions; gene expression;
SF3A3	10	RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; catalytic step 2 spliceosome; nuclear speck; RNA splicing, via transesterification reactions; gene expression;
U2AF1	10	RNA splicing; RNA binding; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; catalytic step 2 spliceosome; nuclear speck; gene expression;
DDX23	9	RNA splicing; mRNA splicing, via spliceosome; U5 snRNP; nucleoplasm; spliceosomal complex; protein binding; catalytic step 2 spliceosome; RNA splicing, via transesterification reactions; gene expression;
EFTUD2	9	RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; catalytic step 2 spliceosome; nuclear speck; gene expression;
HNRNPA2B1	9	RNA splicing; RNA binding; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; catalytic step 2 spliceosome; gene expression;
SF3A1	9	RNA splicing; RNA binding; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; catalytic step 2 spliceosome; gene expression;
SF3B4	9	RNA splicing; RNA binding; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; RNA splicing, via transesterification reactions; gene expression;
SNRPG	9	RNA splicing; RNA binding; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; catalytic step 2 spliceosome; gene expression;
HNRNPA1	8	RNA splicing; RNA binding; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; gene expression;
HNRNPC	8	RNA splicing; RNA binding; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; catalytic step 2 spliceosome; gene expression;
PRPF4	8	RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; nuclear speck; RNA splicing, via transesterification reactions; gene expression;
SF3B3	8	RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; RNA splicing, via transesterification reactions; gene expression;
SNRNP200	8	RNA splicing; mRNA splicing, via spliceosome; U5 snRNP; nucleoplasm; spliceosomal complex; protein binding; catalytic step 2 spliceosome; gene expression;
SNRPA1	8	RNA splicing; RNA binding; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; catalytic step 2 spliceosome; gene expression;
SNRPB	8	RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; catalytic step 2 spliceosome; gene expression;
SNRPB2	8	RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; catalytic step 2 spliceosome; gene expression;
SNRPD3	8	RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; catalytic step 2 spliceosome; gene expression;
SNRPF	8	RNA splicing; RNA binding; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; gene expression;
U2AF2	8	RNA splicing; RNA binding; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; gene expression;
CD2BP2	7	RNA splicing; mRNA splicing, via spliceosome; U5 snRNP; nucleoplasm; protein binding; nuclear speck; gene expression;
CPSF3	7	RNA splicing; RNA binding; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; protein binding; gene expression;
CPSF7	7	RNA splicing; RNA binding; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; protein binding; gene expression;
HNRNPH1	7	RNA splicing; RNA binding; mRNA splicing, via spliceosome; nucleoplasm; protein binding; catalytic step 2 spliceosome; gene expression;
NCBP1	7	RNA splicing; RNA binding; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; protein binding; gene expression;
SF3A2	7	RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; gene expression;
SF3B2	7	RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; gene expression;
SMNDC1	7	RNA splicing; RNA binding; mRNA processing; spliceosomal complex; protein binding; nuclear speck; RNA splicing, via transesterification reactions;
SNRPA	7	RNA splicing; RNA binding; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; gene expression;
SNRPD1	7	RNA splicing; RNA binding; mRNA splicing, via spliceosome; nucleoplasm; protein binding; catalytic step 2 spliceosome; gene expression;
SNRPD2	7	RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; catalytic step 2 spliceosome; gene expression;
TXNL4A	7	RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; RNA splicing, via transesterification reactions; gene expression;
CDC40	6	RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; catalytic step 2 spliceosome; gene expression;
DHX8	6	RNA splicing; RNA binding; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; catalytic step 2 spliceosome;
FUS	6	RNA splicing; RNA binding; mRNA splicing, via spliceosome; nucleoplasm; protein binding; gene expression;
LSM4	6	RNA splicing; RNA binding; mRNA processing; spliceosomal complex; protein binding; gene expression;
PHF5A	6	RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; nuclear speck; gene expression;
RBM4	6	RNA splicing; RNA binding; mRNA processing; nucleoplasm; protein binding; nuclear speck;
SNW1	6	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; catalytic step 2 spliceosome; gene expression;
BCAS2	5	RNA splicing; mRNA processing; spliceosomal complex; protein binding; RNA splicing, via transesterification reactions;
CLP1	5	RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; gene expression;
DHX9	5	RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; protein binding; gene expression;
HSPA8	5	RNA splicing; mRNA processing; spliceosomal complex; protein binding; gene expression;
PCF11	5	RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm; gene expression;
POLR2G	5	RNA splicing; RNA binding; mRNA splicing, via spliceosome; nucleoplasm; gene expression;
SMC1A	5	RNA splicing; mRNA splicing, via spliceosome; nucleoplasm; protein binding; gene expression;
ZCRB1	5	RNA splicing; RNA binding; mRNA processing; nucleoplasm; spliceosomal complex;
CWC15	5	RNA binding; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; catalytic step 2 spliceosome;
SLU7	5	mRNA splicing, via spliceosome; spliceosomal complex; catalytic step 2 spliceosome; nuclear speck; RNA splicing, via transesterification reactions;

Genes shared at least 2 KEGG pathways with PRPF8 (count: 0)

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Region: chr17:1553923..1588176 View in gBrowse