ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CWC15
Symbol Alias	C11orf5, HSPC148, Cwf15
Approved Name	CWC15 spliceosome-associated protein homolog (S. cerevisiae)
Previous Name	CWC15 homolog (S. cerevisiae)
Location	11q21
Position	chr11:94695787-94706776, -
External Links	HGNC: 26939 Entrez Gene: 51503 Ensembl: ENSG00000150316 UCSC: uc001pfd.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 6)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component		51

GO terms by database search (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005634	nucleus	Cellular Component	NAS[10873569]	770
GO:0005515	protein binding	Molecular Function		910
GO:0003723	RNA binding	Molecular Function		104
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[11991638]	54
GO:0071013	catalytic step 2 spliceosome	Cellular Component	IDA[11991638]	31

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with CWC15 (count: 17)

Gene Symbol	Pathway Count	Pathway List
DHX8	6	nucleus; protein binding; RNA binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; spliceosomal complex;
HNRNPA2B1	6	nucleus; protein binding; RNA binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; spliceosomal complex;
PRPF6	6	nucleus; protein binding; RNA binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; spliceosomal complex;
SF3A1	6	nucleus; protein binding; RNA binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; spliceosomal complex;
U2AF1	6	nucleus; protein binding; RNA binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; spliceosomal complex;
DDX23	5	nucleus; protein binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; spliceosomal complex;
EFTUD2	5	nucleus; protein binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; spliceosomal complex;
HNRNPA1	5	nucleus; RNA binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; spliceosomal complex;
HNRNPH1	5	nucleus; protein binding; RNA binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SF3A3	5	nucleus; protein binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; spliceosomal complex;
SNRNP200	5	nucleus; protein binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; spliceosomal complex;
SNRPD1	5	nucleus; protein binding; RNA binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNW1	5	nucleus; protein binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; spliceosomal complex;
HNRNPC	5	protein binding; RNA binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; spliceosomal complex;
PRPF8	5	protein binding; RNA binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; spliceosomal complex;
SNRPA1	5	protein binding; RNA binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; spliceosomal complex;
SNRPG	5	protein binding; RNA binding; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; spliceosomal complex;

Genes shared at least 2 KEGG pathways with CWC15 (count: 0)

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Region: chr11:94695787..94706776 View in gBrowse