ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HNRNPC
Previous Symbol	HNRPC
Symbol Alias	hnRNPC
Approved Name	heterogeneous nuclear ribonucleoprotein C (C1/C2)
Location	14q11
Position	chr14:21677295-21737638, -
External Links	HGNC: 5035 Entrez Gene: 3183 Ensembl: ENSG00000092199 UCSC: uc001waa.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component	IDA[9731529]	51

GO terms by database search (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0071013	catalytic step 2 spliceosome	Cellular Component	IDA[11991638]	31
GO:0000166	nucleotide binding	Molecular Function		73
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[9731529]	54
GO:0003723	RNA binding	Molecular Function	NAS[9731529]	104
GO:0005515	protein binding	Molecular Function	IPI[17289661]	910
GO:0005654	nucleoplasm	Cellular Component		183
GO:0008380	RNA splicing	Biological Process		65
GO:0010467	gene expression	Biological Process		140
GO:0042802	identical protein binding	Molecular Function	IPI[16189514]	70

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with HNRNPC (count: 44)

Gene Symbol	Pathway Count	Pathway List
HNRNPA2B1	9	catalytic step 2 spliceosome; nucleotide binding; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
U2AF1	9	catalytic step 2 spliceosome; nucleotide binding; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
HNRNPA1	8	catalytic step 2 spliceosome; nucleotide binding; mRNA splicing, via spliceosome; RNA binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
HNRNPH1	8	catalytic step 2 spliceosome; nucleotide binding; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression;
PRPF6	8	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
PRPF8	8	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SF3A1	8	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SNRPA1	8	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SNRPB2	8	catalytic step 2 spliceosome; nucleotide binding; mRNA splicing, via spliceosome; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SNRPG	8	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SF3B4	8	nucleotide binding; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SNRPA	8	nucleotide binding; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
U2AF2	8	nucleotide binding; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
DDX23	7	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
EFTUD2	7	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SF3A3	7	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SNRNP200	7	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SNRPB	7	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SNRPD1	7	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression;
SNRPD2	7	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SNRPD3	7	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SNRPF	7	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; RNA binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
CPSF7	7	nucleotide binding; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression;
FUS	7	nucleotide binding; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression;
CDC40	6	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
DHX8	6	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; RNA binding; protein binding; spliceosomal complex; RNA splicing;
SF3A2	6	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SF3B2	6	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SF3B3	6	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
SNW1	6	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; protein binding; nucleoplasm; spliceosomal complex; gene expression;
CPSF3	6	mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression;
NCBP1	6	mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression;
PRPF4	6	mRNA splicing, via spliceosome; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
TXNL4A	6	mRNA splicing, via spliceosome; protein binding; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
CWC15	5	catalytic step 2 spliceosome; mRNA splicing, via spliceosome; RNA binding; protein binding; spliceosomal complex;
RBM4	5	nucleotide binding; RNA binding; protein binding; nucleoplasm; RNA splicing;
ZCRB1	5	nucleotide binding; RNA binding; nucleoplasm; spliceosomal complex; RNA splicing;
ZRSR2	5	nucleotide binding; mRNA splicing, via spliceosome; protein binding; spliceosomal complex; RNA splicing;
CD2BP2	5	mRNA splicing, via spliceosome; protein binding; nucleoplasm; RNA splicing; gene expression;
DHX9	5	mRNA splicing, via spliceosome; protein binding; nucleoplasm; RNA splicing; gene expression;
PHF5A	5	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing; gene expression;
POLR2G	5	mRNA splicing, via spliceosome; RNA binding; nucleoplasm; RNA splicing; gene expression;
SMC1A	5	mRNA splicing, via spliceosome; protein binding; nucleoplasm; RNA splicing; gene expression;
LSM4	5	RNA binding; protein binding; spliceosomal complex; RNA splicing; gene expression;

Genes shared at least 2 KEGG pathways with HNRNPC (count: 0)

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Region: chr14:21677295..21737638 View in gBrowse