ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PRPF4
Symbol Alias	Prp4p, HPRP4, HPRP4P, PRP4
Approved Name	PRP4 pre-mRNA processing factor 4 homolog (yeast)
Name Alias	PRP4/STK/WD splicing factor, "U4/U6 small nuclear ribonucleoprotein Prp4"
Location	9q31-q33
Position	chr9:116037623-116055466, +
External Links	HGNC: 17349 Entrez Gene: 9128 Ensembl: ENSG00000136875 UCSC: uc004bgx.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q31.1-33.1	chr9:102600000-122500000	1 (1/0/0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component	IC[9570313]; NAS[9328476]	51

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0071001	U4/U6 snRNP	Cellular Component	IDA[9570313]	3
GO:0008380	RNA splicing	Biological Process		65
GO:0010467	gene expression	Biological Process		140
GO:0015030	Cajal body	Cellular Component	IDA[15257298]	11
GO:0016607	nuclear speck	Cellular Component		34
GO:0006396	RNA processing	Biological Process	TAS[9328476]	11
GO:0005730	nucleolus	Cellular Component		243
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[9570313]	910
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[9570313]	54
GO:0000375	RNA splicing, via transesterification reactions	Biological Process	NAS[9328476]	11

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with PRPF4 (count: 62)

Gene Symbol	Pathway Count	Pathway List
PRPF6	10	U4/U6 snRNP; RNA splicing; gene expression; nuclear speck; spliceosomal complex; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions;
EFTUD2	10	RNA splicing; gene expression; Cajal body; nuclear speck; nucleolus; spliceosomal complex; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome;
SF3A3	10	RNA splicing; gene expression; nuclear speck; nucleolus; spliceosomal complex; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions;
U2AF1	10	RNA splicing; gene expression; Cajal body; nuclear speck; nucleolus; spliceosomal complex; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome;
DDX23	9	RNA splicing; gene expression; nucleolus; spliceosomal complex; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions;
HNRNPA2B1	8	RNA splicing; gene expression; nucleolus; spliceosomal complex; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome;
HNRNPH1	8	RNA splicing; gene expression; RNA processing; nucleolus; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome;
PRPF8	8	RNA splicing; gene expression; nuclear speck; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions;
SF3A1	8	RNA splicing; gene expression; nucleolus; spliceosomal complex; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome;
SNRNP200	8	RNA splicing; gene expression; nucleolus; spliceosomal complex; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome;
CD2BP2	7	RNA splicing; gene expression; nuclear speck; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome;
DHX8	7	RNA splicing; RNA processing; nucleolus; spliceosomal complex; nucleus; protein binding; mRNA splicing, via spliceosome;
DHX9	7	RNA splicing; gene expression; nucleolus; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome;
FUS	7	RNA splicing; gene expression; nucleolus; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome;
HNRNPA1	7	RNA splicing; gene expression; nucleolus; spliceosomal complex; nucleoplasm; nucleus; mRNA splicing, via spliceosome;
RBM4	7	RNA splicing; nuclear speck; RNA processing; nucleolus; nucleoplasm; nucleus; protein binding;
SF3B2	7	RNA splicing; gene expression; nucleolus; spliceosomal complex; nucleoplasm; nucleus; mRNA splicing, via spliceosome;
SF3B4	7	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions;
SMC1A	7	RNA splicing; gene expression; nucleolus; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome;
SMNDC1	7	RNA splicing; Cajal body; nuclear speck; spliceosomal complex; nucleus; protein binding; RNA splicing, via transesterification reactions;
TXNL4A	7	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions;
SNW1	7	gene expression; nucleolus; spliceosomal complex; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome;
CPSF7	6	RNA splicing; gene expression; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome;
HNRNPC	6	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
HSPA8	6	RNA splicing; gene expression; nucleolus; spliceosomal complex; nucleus; protein binding;
NCBP1	6	RNA splicing; gene expression; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome;
PHF5A	6	RNA splicing; gene expression; nuclear speck; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome;
SF3B3	6	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions;
SNRPA	6	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SNRPA1	6	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SNRPB	6	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SNRPB2	6	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SNRPD1	6	RNA splicing; gene expression; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome;
SNRPD2	6	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SNRPD3	6	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
SNRPG	6	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
U2AF2	6	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
MAML1	6	gene expression; nuclear speck; nucleolus; nucleoplasm; nucleus; protein binding;
SART1	6	Cajal body; nucleolus; nucleoplasm; nucleus; protein binding; mRNA splicing, via spliceosome;
SLU7	6	nuclear speck; nucleolus; spliceosomal complex; nucleus; mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions;
PPIH	5	U4/U6 snRNP; nuclear speck; spliceosomal complex; protein binding; mRNA splicing, via spliceosome;
BCAS2	5	RNA splicing; nucleolus; spliceosomal complex; protein binding; RNA splicing, via transesterification reactions;
CDC40	5	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome;
CDK12	5	RNA splicing; nuclear speck; nucleolus; nucleus; protein binding;
CPSF3	5	RNA splicing; gene expression; nucleoplasm; protein binding; mRNA splicing, via spliceosome;
POLR2G	5	RNA splicing; gene expression; nucleoplasm; nucleus; mRNA splicing, via spliceosome;
SF3A2	5	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome;
SNRPF	5	RNA splicing; gene expression; spliceosomal complex; nucleoplasm; mRNA splicing, via spliceosome;
DGCR8	5	gene expression; nucleolus; nucleoplasm; nucleus; protein binding;
MAPK3	5	gene expression; nucleolus; nucleoplasm; nucleus; protein binding;
MED1	5	gene expression; nucleolus; nucleoplasm; nucleus; protein binding;
MED4	5	gene expression; nucleolus; nucleoplasm; nucleus; protein binding;
MEN1	5	gene expression; nucleolus; nucleoplasm; nucleus; protein binding;
NCOR2	5	gene expression; nucleolus; nucleoplasm; nucleus; protein binding;
PGR	5	gene expression; nucleolus; nucleoplasm; nucleus; protein binding;
RBPJ	5	gene expression; nucleolus; nucleoplasm; nucleus; protein binding;
SSRP1	5	gene expression; nucleolus; nucleoplasm; nucleus; protein binding;
TAF13	5	gene expression; nucleolus; nucleoplasm; nucleus; protein binding;
XPO1	5	gene expression; Cajal body; nucleolus; nucleoplasm; protein binding;
HINFP	5	Cajal body; nucleolus; nucleoplasm; nucleus; protein binding;
RFWD2	5	nuclear speck; nucleolus; nucleoplasm; nucleus; protein binding;
ATXN1	5	RNA processing; nucleolus; nucleoplasm; nucleus; protein binding;

Genes shared at least 2 KEGG pathways with PRPF4 (count: 0)

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Region: chr9:116037623..116055466 View in gBrowse