ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CDK12
Previous Symbol	CRKRS
Symbol Alias	CRK7, CRKR, KIAA0904
Approved Name	cyclin-dependent kinase 12
Previous Name	Cdc2-related kinase, arginine/serine-rich
Name Alias	CDC2 related protein kinase 7
Location	17q12
Position	chr17:37617739-37690800, +
External Links	HGNC: 24224 Entrez Gene: 51755 Ensembl: ENSG00000167258 UCSC: uc010cvv.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 34)

Literature-origin SNPs (count: 0)

LD-proxies (count: 34)

rs_ID	Location	Functional Annotation
rs6503521	Chr17:37715551(Fwd)	intron_variant; nc_transcript_variant
rs6503518	Chr17:37660469(Fwd)	intron_variant
rs4488484	Chr17:37717377(Fwd)	intron_variant; nc_transcript_variant
rs11078906	Chr17:37662767(Fwd)	intron_variant
rs12947506	Chr17:37707592(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs11078907	Chr17:37662954(Fwd)	intron_variant
rs7503377	Chr17:37708841(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs7225096	Chr17:37664443(Fwd)	intron_variant
rs11657058	Chr17:37699378(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant
rs11657899	Chr17:37626963(Fwd)	intron_variant; upstream_gene_variant
rs11657153	Chr17:37699729(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant
rs12948906	Chr17:37644854(Fwd)	intron_variant; nc_transcript_variant
rs4795379	Chr17:37674683(Fwd)	intron_variant
rs11870631	Chr17:37645129(Fwd)	intron_variant; nc_transcript_variant
rs8069074	Chr17:37685401(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant
rs2018026	Chr17:37659606(Fwd)	intron_variant
rs11658678	Chr17:37680096(Fwd)	intron_variant; upstream_gene_variant
rs12938099	Chr17:37612910(Fwd)	upstream_gene_variant
rs12937013	Chr17:37665571(Fwd)	intron_variant
rs8065963	Chr17:37681332(Fwd)	intron_variant; upstream_gene_variant
rs12450559	Chr17:37694709(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant
rs4239222	Chr17:37696235(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs12936996	Chr17:37665554(Fwd)	intron_variant
rs7503705	Chr17:37669704(Fwd)	intron_variant
rs11078912	Chr17:37671490(Fwd)	intron_variant
rs11078913	Chr17:37671714(Fwd)	intron_variant
rs11078901	Chr17:37625912(Fwd)	intron_variant; upstream_gene_variant
rs2303316	Chr17:37704217(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs11654018	Chr17:37703740(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant
rs7503069	Chr17:37697128(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs4794814	Chr17:37696852(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs4795384	Chr17:37716771(Fwd)	intron_variant; nc_transcript_variant
rs11078915	Chr17:37715426(Fwd)	intron_variant; nc_transcript_variant
rs7216086	Chr17:37709422(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0046777	protein autophosphorylation	Biological Process	IDA[11683387]	23
GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	Biological Process		1
GO:0030332	cyclin binding	Molecular Function		4
GO:0043405	regulation of MAP kinase activity	Biological Process	IMP[19651820]	2
GO:0016607	nuclear speck	Cellular Component	IDA[11683387]	34
GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex	Cellular Component		1
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	Molecular Function		3
GO:0008380	RNA splicing	Biological Process		65
GO:0005730	nucleolus	Cellular Component		243
GO:0006397	mRNA processing	Biological Process		50
GO:0005524	ATP binding	Molecular Function		228
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[12841360]	910
GO:0004693	cyclin-dependent protein kinase activity	Molecular Function		4
GO:0004672	protein kinase activity	Molecular Function	IDA[11683387]	27
GO:0002944	cyclin K-CDK12 complex	Cellular Component		1

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CDK12 (count: 21)

Gene Symbol	Pathway Count	Pathway List
EFTUD2	6	nuclear speck; RNA splicing; nucleolus; mRNA processing; nucleus; protein binding;
RBM4	6	nuclear speck; RNA splicing; nucleolus; mRNA processing; nucleus; protein binding;
SF3A3	6	nuclear speck; RNA splicing; nucleolus; mRNA processing; nucleus; protein binding;
U2AF1	6	nuclear speck; RNA splicing; nucleolus; mRNA processing; nucleus; protein binding;
HSPA8	6	RNA splicing; nucleolus; mRNA processing; ATP binding; nucleus; protein binding;
THRAP3	6	RNA splicing; nucleolus; mRNA processing; ATP binding; nucleus; protein binding;
NEK6	5	protein autophosphorylation; nuclear speck; ATP binding; nucleus; protein binding;
SMG1	5	protein autophosphorylation; ATP binding; nucleus; protein binding; protein kinase activity;
NSRP1	5	nuclear speck; RNA splicing; mRNA processing; nucleus; protein binding;
PRPF4	5	nuclear speck; RNA splicing; nucleolus; nucleus; protein binding;
SMNDC1	5	nuclear speck; RNA splicing; mRNA processing; nucleus; protein binding;
MAPK1	5	RNA polymerase II carboxy-terminal domain kinase activity; nucleolus; ATP binding; nucleus; protein binding;
DDX23	5	RNA splicing; nucleolus; ATP binding; nucleus; protein binding;
DHX15	5	RNA splicing; nucleolus; mRNA processing; ATP binding; nucleus;
DHX8	5	RNA splicing; nucleolus; ATP binding; nucleus; protein binding;
DHX9	5	RNA splicing; nucleolus; ATP binding; nucleus; protein binding;
HNRNPA2B1	5	RNA splicing; nucleolus; mRNA processing; nucleus; protein binding;
SF3A1	5	RNA splicing; nucleolus; mRNA processing; nucleus; protein binding;
SMC1A	5	RNA splicing; nucleolus; ATP binding; nucleus; protein binding;
SNRNP200	5	RNA splicing; nucleolus; ATP binding; nucleus; protein binding;
TARDBP	5	RNA splicing; nucleolus; mRNA processing; nucleus; protein binding;

Genes shared at least 2 KEGG pathways with CDK12 (count: 0)

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Region: chr17:37617739..37690800 View in gBrowse