ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SF3A3
Symbol Alias	SF3a60, SAP61, PRP9, PRPF9
Approved Name	splicing factor 3a, subunit 3, 60kDa
Previous Name	splicing factor 3a, subunit 3, 60kD
Location	1p
Position	chr1:38422647-38456593, -
External Links	HGNC: 10767 Entrez Gene: 10946 Ensembl: ENSG00000183431 UCSC: uc001cci.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component	IDA[9731529]	51

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[9731529]	54
GO:0003676	nucleic acid binding	Molecular Function		41
GO:0000375	RNA splicing, via transesterification reactions	Biological Process	TAS[7816610]	11
GO:0000389	mRNA 3'-splice site recognition	Biological Process	TAS[15647371]	5
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005515	protein binding	Molecular Function		910
GO:0005634	nucleus	Cellular Component		770
GO:0008380	RNA splicing	Biological Process		65
GO:0008270	zinc ion binding	Molecular Function		323
GO:0006397	mRNA processing	Biological Process	IMP[15647371]	50
GO:0005730	nucleolus	Cellular Component		243
GO:0071013	catalytic step 2 spliceosome	Cellular Component	IDA[11991638]	31
GO:0016607	nuclear speck	Cellular Component		34
GO:0010467	gene expression	Biological Process		140

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with SF3A3 (count: 79)

Gene Symbol	Pathway Count	Pathway List
U2AF1	12	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; nucleus; RNA splicing; zinc ion binding; mRNA processing; nucleolus; catalytic step 2 spliceosome; nuclear speck; gene expression;
DDX23	11	mRNA splicing, via spliceosome; nucleic acid binding; RNA splicing, via transesterification reactions; nucleoplasm; spliceosomal complex; protein binding; nucleus; RNA splicing; nucleolus; catalytic step 2 spliceosome; gene expression;
EFTUD2	11	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; nucleus; RNA splicing; mRNA processing; nucleolus; catalytic step 2 spliceosome; nuclear speck; gene expression;
SF3A1	11	mRNA splicing, via spliceosome; mRNA 3'-splice site recognition; nucleoplasm; spliceosomal complex; protein binding; nucleus; RNA splicing; mRNA processing; nucleolus; catalytic step 2 spliceosome; gene expression;
HNRNPA2B1	10	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; nucleus; RNA splicing; mRNA processing; nucleolus; catalytic step 2 spliceosome; gene expression;
PRPF4	10	mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; nucleoplasm; spliceosomal complex; protein binding; nucleus; RNA splicing; nucleolus; nuclear speck; gene expression;
PRPF6	10	mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; nucleoplasm; spliceosomal complex; protein binding; nucleus; RNA splicing; catalytic step 2 spliceosome; nuclear speck; gene expression;
PRPF8	10	mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; nucleoplasm; spliceosomal complex; protein binding; RNA splicing; mRNA processing; catalytic step 2 spliceosome; nuclear speck; gene expression;
SF3A2	10	mRNA splicing, via spliceosome; nucleic acid binding; mRNA 3'-splice site recognition; nucleoplasm; spliceosomal complex; RNA splicing; zinc ion binding; mRNA processing; catalytic step 2 spliceosome; gene expression;
SF3B2	10	mRNA splicing, via spliceosome; nucleic acid binding; nucleoplasm; spliceosomal complex; nucleus; RNA splicing; mRNA processing; nucleolus; catalytic step 2 spliceosome; gene expression;
SNRNP200	10	mRNA splicing, via spliceosome; nucleic acid binding; nucleoplasm; spliceosomal complex; protein binding; nucleus; RNA splicing; nucleolus; catalytic step 2 spliceosome; gene expression;
HNRNPA1	9	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; nucleus; RNA splicing; mRNA processing; nucleolus; catalytic step 2 spliceosome; gene expression;
SF3B3	9	mRNA splicing, via spliceosome; nucleic acid binding; RNA splicing, via transesterification reactions; nucleoplasm; spliceosomal complex; RNA splicing; mRNA processing; catalytic step 2 spliceosome; gene expression;
SLU7	9	mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; mRNA 3'-splice site recognition; spliceosomal complex; nucleus; zinc ion binding; nucleolus; catalytic step 2 spliceosome; nuclear speck;
FUS	8	mRNA splicing, via spliceosome; nucleoplasm; protein binding; nucleus; RNA splicing; zinc ion binding; nucleolus; gene expression;
HNRNPH1	8	mRNA splicing, via spliceosome; nucleoplasm; protein binding; nucleus; RNA splicing; nucleolus; catalytic step 2 spliceosome; gene expression;
SF3B4	8	mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; nucleoplasm; spliceosomal complex; protein binding; RNA splicing; mRNA processing; gene expression;
SNRPB	8	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; RNA splicing; mRNA processing; catalytic step 2 spliceosome; gene expression;
SNRPB2	8	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; RNA splicing; mRNA processing; catalytic step 2 spliceosome; gene expression;
SNRPD3	8	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; RNA splicing; mRNA processing; catalytic step 2 spliceosome; gene expression;
SNRPG	8	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; RNA splicing; mRNA processing; catalytic step 2 spliceosome; gene expression;
SNW1	8	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; nucleus; nucleolus; catalytic step 2 spliceosome; gene expression;
RBM4	8	nucleoplasm; protein binding; nucleus; RNA splicing; zinc ion binding; mRNA processing; nucleolus; nuclear speck;
CD2BP2	7	mRNA splicing, via spliceosome; nucleoplasm; protein binding; nucleus; RNA splicing; nuclear speck; gene expression;
CPSF7	7	mRNA splicing, via spliceosome; nucleoplasm; protein binding; nucleus; RNA splicing; mRNA processing; gene expression;
DHX8	7	mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleus; RNA splicing; nucleolus; catalytic step 2 spliceosome;
DHX9	7	mRNA splicing, via spliceosome; nucleoplasm; protein binding; nucleus; RNA splicing; nucleolus; gene expression;
HNRNPC	7	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; RNA splicing; catalytic step 2 spliceosome; gene expression;
NCBP1	7	mRNA splicing, via spliceosome; nucleoplasm; protein binding; nucleus; RNA splicing; mRNA processing; gene expression;
SF1	7	mRNA splicing, via spliceosome; nucleic acid binding; mRNA 3'-splice site recognition; spliceosomal complex; nucleus; zinc ion binding; nucleolus;
SMC1A	7	mRNA splicing, via spliceosome; nucleoplasm; protein binding; nucleus; RNA splicing; nucleolus; gene expression;
SNRPA1	7	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; RNA splicing; catalytic step 2 spliceosome; gene expression;
SNRPD1	7	mRNA splicing, via spliceosome; nucleoplasm; protein binding; nucleus; RNA splicing; catalytic step 2 spliceosome; gene expression;
SNRPD2	7	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; RNA splicing; catalytic step 2 spliceosome; gene expression;
SNRPF	7	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing; mRNA processing; catalytic step 2 spliceosome; gene expression;
TXNL4A	7	mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; nucleoplasm; spliceosomal complex; protein binding; RNA splicing; gene expression;
U2AF2	7	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; RNA splicing; mRNA processing; gene expression;
ZMAT5	7	nucleic acid binding; spliceosomal complex; nucleus; RNA splicing; zinc ion binding; mRNA processing; nucleolus;
SMNDC1	7	RNA splicing, via transesterification reactions; spliceosomal complex; protein binding; nucleus; RNA splicing; mRNA processing; nuclear speck;
HSPA8	7	spliceosomal complex; protein binding; nucleus; RNA splicing; mRNA processing; nucleolus; gene expression;
CDC40	6	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing; catalytic step 2 spliceosome; gene expression;
CPSF3	6	mRNA splicing, via spliceosome; nucleoplasm; protein binding; RNA splicing; mRNA processing; gene expression;
PHF5A	6	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; RNA splicing; nuclear speck; gene expression;
SART1	6	mRNA splicing, via spliceosome; nucleoplasm; protein binding; nucleus; nucleolus; catalytic step 2 spliceosome;
SNRPA	6	mRNA splicing, via spliceosome; nucleoplasm; spliceosomal complex; protein binding; RNA splicing; gene expression;
DHX15	6	nucleic acid binding; spliceosomal complex; nucleus; RNA splicing; mRNA processing; nucleolus;
BCAS2	6	RNA splicing, via transesterification reactions; spliceosomal complex; protein binding; RNA splicing; mRNA processing; nucleolus;
MAML1	6	nucleoplasm; protein binding; nucleus; nucleolus; nuclear speck; gene expression;
PGR	6	nucleoplasm; protein binding; nucleus; zinc ion binding; nucleolus; gene expression;
RFWD2	6	nucleoplasm; protein binding; nucleus; zinc ion binding; nucleolus; nuclear speck;
CDK12	6	protein binding; nucleus; RNA splicing; mRNA processing; nucleolus; nuclear speck;
CLP1	5	mRNA splicing, via spliceosome; nucleoplasm; RNA splicing; mRNA processing; gene expression;
CWC15	5	mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleus; catalytic step 2 spliceosome;
PCF11	5	mRNA splicing, via spliceosome; nucleoplasm; RNA splicing; mRNA processing; gene expression;
POLR2G	5	mRNA splicing, via spliceosome; nucleoplasm; nucleus; RNA splicing; gene expression;
PRPF19	5	mRNA splicing, via spliceosome; protein binding; nucleus; catalytic step 2 spliceosome; nuclear speck;
ZRSR2	5	mRNA splicing, via spliceosome; spliceosomal complex; protein binding; RNA splicing; zinc ion binding;
DGCR8	5	nucleoplasm; protein binding; nucleus; nucleolus; gene expression;
ESRRA	5	nucleoplasm; protein binding; nucleus; zinc ion binding; gene expression;
HINFP	5	nucleoplasm; protein binding; nucleus; zinc ion binding; nucleolus;
LSM11	5	nucleoplasm; protein binding; nucleus; mRNA processing; gene expression;
MAPK3	5	nucleoplasm; protein binding; nucleus; nucleolus; gene expression;
MED1	5	nucleoplasm; protein binding; nucleus; nucleolus; gene expression;
MED4	5	nucleoplasm; protein binding; nucleus; nucleolus; gene expression;
MEN1	5	nucleoplasm; protein binding; nucleus; nucleolus; gene expression;
NCOR2	5	nucleoplasm; protein binding; nucleus; nucleolus; gene expression;
NR4A2	5	nucleoplasm; protein binding; nucleus; zinc ion binding; gene expression;
NR5A1	5	nucleoplasm; protein binding; nucleus; zinc ion binding; gene expression;
RBPJ	5	nucleoplasm; protein binding; nucleus; nucleolus; gene expression;
SSRP1	5	nucleoplasm; protein binding; nucleus; nucleolus; gene expression;
TAF13	5	nucleoplasm; protein binding; nucleus; nucleolus; gene expression;
ZCRB1	5	nucleoplasm; spliceosomal complex; RNA splicing; zinc ion binding; mRNA processing;
LSM4	5	spliceosomal complex; protein binding; RNA splicing; mRNA processing; gene expression;
PRPF18	5	spliceosomal complex; nucleus; RNA splicing; mRNA processing; nuclear speck;
SCAF8	5	spliceosomal complex; nucleus; RNA splicing; mRNA processing; nucleolus;
NSRP1	5	protein binding; nucleus; RNA splicing; mRNA processing; nuclear speck;
RCHY1	5	protein binding; nucleus; zinc ion binding; nucleolus; nuclear speck;
TARDBP	5	protein binding; nucleus; RNA splicing; mRNA processing; nucleolus;
THRAP3	5	protein binding; nucleus; RNA splicing; mRNA processing; nucleolus;

Genes shared at least 2 KEGG pathways with SF3A3 (count: 0)

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Region: chr1:38422647..38456593 View in gBrowse