ADHDgene Database

Gene Report

Basic Info

Approved Symbol	PRPF18
Symbol Alias	hPrp18
Approved Name	PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
Previous Name	PRP18 pre-mRNA processing factor 18 homolog (yeast)
Location	10p12.33
Position	chr10:13628927-13672868, +
External Links	HGNC: 17351 Entrez Gene: 8559 Ensembl: ENSG00000165630 UCSC: uc001imp.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component		51

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008380	RNA splicing	Biological Process		65
GO:0016607	nuclear speck	Cellular Component		34
GO:0005634	nucleus	Cellular Component	TAS[9000057]	770
GO:0006397	mRNA processing	Biological Process		50

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with PRPF18 (count: 4)

Gene Symbol	Pathway Count	Pathway List
EFTUD2	5	RNA splicing; nuclear speck; nucleus; mRNA processing; spliceosomal complex;
SF3A3	5	RNA splicing; nuclear speck; nucleus; mRNA processing; spliceosomal complex;
SMNDC1	5	RNA splicing; nuclear speck; nucleus; mRNA processing; spliceosomal complex;
U2AF1	5	RNA splicing; nuclear speck; nucleus; mRNA processing; spliceosomal complex;

Genes shared at least 2 KEGG pathways with PRPF18 (count: 0)

View in gBrowse

Region: chr10:13628927..13672868 View in gBrowse