ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	LSM4
Symbol Alias	YER112W
Approved Name	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Location	19p13.1
Position	chr19:18417717-18434001, -
External Links	HGNC: 17259 Entrez Gene: 25804 Ensembl: ENSG00000130520 UCSC: uc002niq.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component		51

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	Biological Process		7
GO:0003723	RNA binding	Molecular Function		104
GO:0005515	protein binding	Molecular Function		910
GO:0005688	U6 snRNP	Cellular Component	TAS[10369684]	1
GO:0005829	cytosol	Cellular Component		447
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	Biological Process		4
GO:0030532	small nuclear ribonucleoprotein complex	Cellular Component	TAS[10369684]	12
GO:0016071	mRNA metabolic process	Biological Process		34
GO:0016070	RNA metabolic process	Biological Process		46
GO:0010467	gene expression	Biological Process		140
GO:0008380	RNA splicing	Biological Process		65
GO:0006397	mRNA processing	Biological Process		50

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...
hsa03018	RNA degradation	8	The correct processing, quality control and turnover of cell...... The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex. More...

Genes shared at least 5 GO terms with LSM4 (count: 53)

Gene Symbol	Pathway Count	Pathway List
SNRPG	9	RNA binding; protein binding; spliceosomal complex; cytosol; small nuclear ribonucleoprotein complex; RNA metabolic process; gene expression; RNA splicing; mRNA processing;
DDX6	8	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; RNA binding; protein binding; cytosol; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; mRNA metabolic process; RNA metabolic process; gene expression;
PATL1	8	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; RNA binding; protein binding; cytosol; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; mRNA metabolic process; RNA metabolic process; gene expression;
NCBP1	8	RNA binding; protein binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression; RNA splicing; mRNA processing;
SNRPF	8	RNA binding; spliceosomal complex; cytosol; small nuclear ribonucleoprotein complex; RNA metabolic process; gene expression; RNA splicing; mRNA processing;
HSPA8	8	protein binding; spliceosomal complex; cytosol; mRNA metabolic process; RNA metabolic process; gene expression; RNA splicing; mRNA processing;
SNRPB	8	protein binding; spliceosomal complex; cytosol; small nuclear ribonucleoprotein complex; RNA metabolic process; gene expression; RNA splicing; mRNA processing;
SNRPD3	8	protein binding; spliceosomal complex; cytosol; small nuclear ribonucleoprotein complex; RNA metabolic process; gene expression; RNA splicing; mRNA processing;
CNOT6	7	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; RNA binding; protein binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
DCPS	7	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; protein binding; cytosol; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; mRNA metabolic process; RNA metabolic process; gene expression;
SNRPD1	7	RNA binding; protein binding; cytosol; small nuclear ribonucleoprotein complex; RNA metabolic process; gene expression; RNA splicing;
SNRPD2	7	protein binding; spliceosomal complex; cytosol; small nuclear ribonucleoprotein complex; RNA metabolic process; gene expression; RNA splicing;
RQCD1	6	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; protein binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
HNRNPA2B1	6	RNA binding; protein binding; spliceosomal complex; gene expression; RNA splicing; mRNA processing;
PRPF8	6	RNA binding; protein binding; spliceosomal complex; gene expression; RNA splicing; mRNA processing;
RPL13	6	RNA binding; protein binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
RPL14	6	RNA binding; protein binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
SF3A1	6	RNA binding; protein binding; spliceosomal complex; gene expression; RNA splicing; mRNA processing;
SF3B4	6	RNA binding; protein binding; spliceosomal complex; gene expression; RNA splicing; mRNA processing;
SNRPA1	6	RNA binding; protein binding; spliceosomal complex; small nuclear ribonucleoprotein complex; gene expression; RNA splicing;
U2AF1	6	RNA binding; protein binding; spliceosomal complex; gene expression; RNA splicing; mRNA processing;
U2AF2	6	RNA binding; protein binding; spliceosomal complex; gene expression; RNA splicing; mRNA processing;
XPO1	6	RNA binding; protein binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
TNKS1BP1	5	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
CPSF3	5	RNA binding; protein binding; gene expression; RNA splicing; mRNA processing;
CPSF7	5	RNA binding; protein binding; gene expression; RNA splicing; mRNA processing;
FAU	5	RNA binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
HNRNPA1	5	RNA binding; spliceosomal complex; gene expression; RNA splicing; mRNA processing;
HNRNPC	5	RNA binding; protein binding; spliceosomal complex; gene expression; RNA splicing;
PRPF6	5	RNA binding; protein binding; spliceosomal complex; gene expression; RNA splicing;
RPL12	5	RNA binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
RPL37	5	RNA binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
RPL38	5	RNA binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
RPS15A	5	RNA binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
RPS25	5	RNA binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
SMNDC1	5	RNA binding; protein binding; spliceosomal complex; RNA splicing; mRNA processing;
SNRPA	5	RNA binding; protein binding; spliceosomal complex; gene expression; RNA splicing;
SNRPN	5	RNA binding; protein binding; spliceosomal complex; small nuclear ribonucleoprotein complex; RNA splicing;
EFTUD2	5	protein binding; spliceosomal complex; gene expression; RNA splicing; mRNA processing;
PSMB7	5	protein binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
PSMC3	5	protein binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
PSMD5	5	protein binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
PSMD7	5	protein binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
RPS3	5	protein binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
RPS9	5	protein binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
SF3A3	5	protein binding; spliceosomal complex; gene expression; RNA splicing; mRNA processing;
SMG1	5	protein binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
SMG7	5	protein binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
SNRPB2	5	protein binding; spliceosomal complex; gene expression; RNA splicing; mRNA processing;
UBB	5	protein binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
UBC	5	protein binding; cytosol; mRNA metabolic process; RNA metabolic process; gene expression;
SF3A2	5	spliceosomal complex; small nuclear ribonucleoprotein complex; gene expression; RNA splicing; mRNA processing;
SF3B3	5	spliceosomal complex; small nuclear ribonucleoprotein complex; gene expression; RNA splicing; mRNA processing;

Genes shared at least 2 KEGG pathways with LSM4 (count: 0)

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Region: chr19:18417717..18434001 View in gBrowse