ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SMG7
Previous Symbol	C1orf16
Symbol Alias	KIAA0250, EST1C, SGA56M, SMG-7
Approved Name	SMG7 nonsense mediated mRNA decay factor
Previous Name	"chromosome 1 open reading frame 16", "smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)"
Name Alias	"EST1 telomerase component homolog C (S. cerevisiae)"
Location	1q25
Position	chr1:183441351-183567381, 1
External Links	HGNC: 16792 Entrez Gene: 9887 Ensembl: ENSG00000116698 UCSC: uc001gqf.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.3	chr1:180300000-185800000	1 (1/0/0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035303	regulation of dephosphorylation	biological process	TAS[15721257]	1
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0051721	protein phosphatase 2A binding	molecular function	IDA[14636577]	5
GO:0005829	cytosol	cellular component	TAS	485
GO:0016071	mRNA metabolic process	biological process	TAS	41
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	biological process	TAS	23
GO:0006406	mRNA export from nucleus	biological process	TAS[16488880]	15
GO:0005634	nucleus	cellular component	IDA[14636577]	877
GO:0010467	gene expression	biological process	TAS	154
GO:0016070	RNA metabolic process	biological process	TAS	54
GO:0045111	intermediate filament cytoskeleton	cellular component	IDA	6
GO:0005515	protein binding	molecular function	IPI[14636577]	1015

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with SMG7 (count: 47)

Gene Symbol	Pathway Count	Pathway List
RNPS1	9	cytoplasm; cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; nucleus; gene expression; RNA metabolic process; protein binding;
SMG1	9	cytoplasm; cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; nucleus; gene expression; RNA metabolic process; protein binding;
PARN	8	cytoplasm; cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; gene expression; RNA metabolic process; protein binding;
RPS3	8	cytoplasm; cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nucleus; gene expression; RNA metabolic process; protein binding;
NCBP1	8	cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; nucleus; gene expression; RNA metabolic process; protein binding;
DCPS	7	cytoplasm; cytosol; mRNA metabolic process; nucleus; gene expression; RNA metabolic process; protein binding;
RPS9	7	cytoplasm; cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; gene expression; RNA metabolic process; protein binding;
RPL14	7	cytoplasm; cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; gene expression; RNA metabolic process; protein binding;
PSMC3	7	cytoplasm; cytosol; mRNA metabolic process; nucleus; gene expression; RNA metabolic process; protein binding;
GEMIN2	6	cytoplasm; cytosol; nucleus; gene expression; RNA metabolic process; protein binding;
TNKS1BP1	6	cytoplasm; cytosol; mRNA metabolic process; nucleus; gene expression; RNA metabolic process;
RPS15A	6	cytoplasm; cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; gene expression; RNA metabolic process;
XPO1	6	cytoplasm; cytosol; mRNA metabolic process; gene expression; RNA metabolic process; protein binding;
RPS25	6	cytoplasm; cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; gene expression; RNA metabolic process;
RPL35	6	cytoplasm; cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; gene expression; RNA metabolic process;
PAIP1	6	cytoplasm; cytosol; mRNA metabolic process; gene expression; RNA metabolic process; protein binding;
HSPA8	6	cytosol; mRNA metabolic process; nucleus; gene expression; RNA metabolic process; protein binding;
CNOT6	6	cytosol; mRNA metabolic process; nucleus; gene expression; RNA metabolic process; protein binding;
RQCD1	6	cytosol; mRNA metabolic process; nucleus; gene expression; RNA metabolic process; protein binding;
RPL13	6	cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; gene expression; RNA metabolic process; protein binding;
RPL27A	6	cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; gene expression; RNA metabolic process; protein binding;
RPS2	6	cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; gene expression; RNA metabolic process; protein binding;
RPS10	6	cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; gene expression; RNA metabolic process; protein binding;
NEDD4L	5	cytoplasm; cytosol; nucleus; gene expression; protein binding;
PSME1	5	cytoplasm; cytosol; mRNA metabolic process; gene expression; RNA metabolic process;
YAP1	5	cytoplasm; cytosol; nucleus; gene expression; protein binding;
IARS	5	cytoplasm; cytosol; nucleus; gene expression; protein binding;
MEN1	5	cytoplasm; cytosol; nucleus; gene expression; protein binding;
PDCD4	5	cytoplasm; cytosol; nucleus; RNA metabolic process; protein binding;
RPL37	5	cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; gene expression; RNA metabolic process;
UBC	5	cytosol; mRNA metabolic process; gene expression; RNA metabolic process; protein binding;
RPL12	5	cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; gene expression; RNA metabolic process;
RPL38	5	cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; gene expression; RNA metabolic process;
PSMD5	5	cytosol; mRNA metabolic process; gene expression; RNA metabolic process; protein binding;
DDX6	5	cytosol; mRNA metabolic process; gene expression; RNA metabolic process; protein binding;
RPS12	5	cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; gene expression; RNA metabolic process;
RPL3L	5	cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; gene expression; RNA metabolic process;
CLNS1A	5	cytosol; nucleus; gene expression; RNA metabolic process; protein binding;
PSMD7	5	cytosol; mRNA metabolic process; gene expression; RNA metabolic process; protein binding;
RPL37A	5	cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; gene expression; RNA metabolic process;
LSM4	5	cytosol; mRNA metabolic process; gene expression; RNA metabolic process; protein binding;
UBB	5	cytosol; mRNA metabolic process; gene expression; RNA metabolic process; protein binding;
PATL1	5	cytosol; mRNA metabolic process; gene expression; RNA metabolic process; protein binding;
SNRPD1	5	cytosol; nucleus; gene expression; RNA metabolic process; protein binding;
FAU	5	cytosol; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; gene expression; RNA metabolic process;
PSMA8	5	cytosol; mRNA metabolic process; nucleus; gene expression; RNA metabolic process;
PSMB7	5	cytosol; mRNA metabolic process; gene expression; RNA metabolic process; protein binding;

Genes shared at least 2 KEGG pathways with SMG7 (count: 0)

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Region: chr1:183441351..183567381 View in gBrowse