ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CLNS1A
Previous Symbol	CLCI
Symbol Alias	ICln
Approved Name	chloride channel, nucleotide-sensitive, 1A
Location	11q13.5-q14
Position	chr11:77225981-77348851, -
External Links	HGNC: 2080 Entrez Gene: 1207 Ensembl: ENSG00000074201 UCSC: uc001oyk.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000387	spliceosomal snRNP assembly	Biological Process		10
GO:0005829	cytosol	Cellular Component		447
GO:0005856	cytoskeleton	Cellular Component		54
GO:0005515	protein binding	Molecular Function		910
GO:0005634	nucleus	Cellular Component		770
GO:0006821	chloride transport	Biological Process		4
GO:0006884	cell volume homeostasis	Biological Process		2
GO:0005886	plasma membrane	Cellular Component	TAS[9359436]	772
GO:0006810	transport	Biological Process	TAS[7887970]	62
GO:0016070	RNA metabolic process	Biological Process		46
GO:0034660	ncRNA metabolic process	Biological Process		8
GO:0008015	blood circulation	Biological Process	TAS[9359436]	12
GO:0010467	gene expression	Biological Process		140

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03013	RNA transport	15	RNA transport from the nucleus to the cytoplasm is fundamen...... RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation. More...

Genes shared at least 5 GO terms with CLNS1A (count: 20)

Gene Symbol	Pathway Count	Pathway List
NCBP1	7	spliceosomal snRNP assembly; cytosol; protein binding; nucleus; RNA metabolic process; ncRNA metabolic process; gene expression;
SNRPD1	7	spliceosomal snRNP assembly; cytosol; protein binding; nucleus; RNA metabolic process; ncRNA metabolic process; gene expression;
SNRPB	6	spliceosomal snRNP assembly; cytosol; protein binding; RNA metabolic process; ncRNA metabolic process; gene expression;
SNRPD2	6	spliceosomal snRNP assembly; cytosol; protein binding; RNA metabolic process; ncRNA metabolic process; gene expression;
SNRPD3	6	spliceosomal snRNP assembly; cytosol; protein binding; RNA metabolic process; ncRNA metabolic process; gene expression;
SNRPG	6	spliceosomal snRNP assembly; cytosol; protein binding; RNA metabolic process; ncRNA metabolic process; gene expression;
HSPA8	6	cytosol; protein binding; nucleus; plasma membrane; RNA metabolic process; gene expression;
SNRPF	5	spliceosomal snRNP assembly; cytosol; RNA metabolic process; ncRNA metabolic process; gene expression;
AKAP7	5	cytosol; protein binding; nucleus; plasma membrane; RNA metabolic process;
CNOT6	5	cytosol; protein binding; nucleus; RNA metabolic process; gene expression;
DCPS	5	cytosol; protein binding; nucleus; RNA metabolic process; gene expression;
MAPK3	5	cytosol; cytoskeleton; protein binding; nucleus; gene expression;
PSMC3	5	cytosol; protein binding; nucleus; RNA metabolic process; gene expression;
RPS3	5	cytosol; protein binding; nucleus; RNA metabolic process; gene expression;
RQCD1	5	cytosol; protein binding; nucleus; RNA metabolic process; gene expression;
SMG1	5	cytosol; protein binding; nucleus; RNA metabolic process; gene expression;
SMG7	5	cytosol; protein binding; nucleus; RNA metabolic process; gene expression;
TNKS1BP1	5	cytosol; cytoskeleton; nucleus; RNA metabolic process; gene expression;
UBB	5	cytosol; protein binding; plasma membrane; RNA metabolic process; gene expression;
UBC	5	cytosol; protein binding; plasma membrane; RNA metabolic process; gene expression;

Genes shared at least 2 KEGG pathways with CLNS1A (count: 0)

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Region: chr11:77225981..77348851 View in gBrowse