ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PDCD4
Symbol Alias	H731
Approved Name	programmed cell death 4 (neoplastic transformation inhibitor)
Name Alias	nuclear antigen H731
Location	10q24
Position	chr10:112631565-112659764, +
External Links	HGNC: 8763 Entrez Gene: 27250 Ensembl: ENSG00000150593 UCSC: uc001kzh.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 0)

LD-proxies (count: 1)

rs_ID	Location	Functional Annotation
rs10787289	Chr10:112657207(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045786	negative regulation of cell cycle	Biological Process	NAS[12054647]	9
GO:0043508	negative regulation of JUN kinase activity	Biological Process		2
GO:0016070	RNA metabolic process	Biological Process		46
GO:0007569	cell aging	Biological Process	IDA[12054647]	4
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA[16357133]	64
GO:0005634	nucleus	Cellular Component	IMP[16357133]	770
GO:0005515	protein binding	Molecular Function		910
GO:0003723	RNA binding	Molecular Function		104
GO:0006915	apoptotic process	Biological Process	NAS[12054647]	111
GO:0005829	cytosol	Cellular Component	IDA[12054647]	447
GO:0005737	cytoplasm	Cellular Component	IMP[16357133]	690
GO:0005730	nucleolus	Cellular Component		243

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PDCD4 (count: 61)

Gene Symbol	Pathway Count	Pathway List
MEN1	7	negative regulation of cell cycle; negative regulation of transcription, DNA-dependent; nucleus; protein binding; cytosol; cytoplasm; nucleolus;
DAXX	7	negative regulation of transcription, DNA-dependent; nucleus; protein binding; apoptotic process; cytosol; cytoplasm; nucleolus;
ATXN2	6	RNA metabolic process; nucleus; protein binding; RNA binding; cytoplasm; nucleolus;
DCPS	6	RNA metabolic process; nucleus; protein binding; cytosol; cytoplasm; nucleolus;
HSPA8	6	RNA metabolic process; negative regulation of transcription, DNA-dependent; nucleus; protein binding; cytosol; nucleolus;
PSMC3	6	RNA metabolic process; nucleus; protein binding; apoptotic process; cytosol; cytoplasm;
XPO1	6	RNA metabolic process; protein binding; RNA binding; cytosol; cytoplasm; nucleolus;
GSK3B	6	negative regulation of transcription, DNA-dependent; nucleus; protein binding; cytosol; cytoplasm; nucleolus;
ID2	6	negative regulation of transcription, DNA-dependent; nucleus; protein binding; cytosol; cytoplasm; nucleolus;
ALKBH8	6	nucleus; protein binding; RNA binding; cytosol; cytoplasm; nucleolus;
MAPK1	6	nucleus; protein binding; apoptotic process; cytosol; cytoplasm; nucleolus;
GSTP1	5	negative regulation of JUN kinase activity; nucleus; protein binding; cytosol; cytoplasm;
CNOT6	5	RNA metabolic process; nucleus; protein binding; RNA binding; cytosol;
NCBP1	5	RNA metabolic process; nucleus; protein binding; RNA binding; cytosol;
RPL14	5	RNA metabolic process; protein binding; RNA binding; cytosol; cytoplasm;
RPS25	5	RNA metabolic process; RNA binding; cytosol; cytoplasm; nucleolus;
RPS3	5	RNA metabolic process; nucleus; protein binding; cytosol; cytoplasm;
RPS9	5	RNA metabolic process; protein binding; cytosol; cytoplasm; nucleolus;
SMG1	5	RNA metabolic process; nucleus; protein binding; cytosol; cytoplasm;
SMG7	5	RNA metabolic process; nucleus; protein binding; cytosol; cytoplasm;
SNRPD1	5	RNA metabolic process; nucleus; protein binding; RNA binding; cytosol;
ATXN1	5	negative regulation of transcription, DNA-dependent; nucleus; protein binding; cytoplasm; nucleolus;
BCLAF1	5	negative regulation of transcription, DNA-dependent; nucleus; protein binding; cytoplasm; nucleolus;
BRMS1	5	negative regulation of transcription, DNA-dependent; nucleus; protein binding; apoptotic process; cytoplasm;
KAT5	5	negative regulation of transcription, DNA-dependent; nucleus; protein binding; cytosol; nucleolus;
RBPJ	5	negative regulation of transcription, DNA-dependent; nucleus; protein binding; cytoplasm; nucleolus;
RELA	5	negative regulation of transcription, DNA-dependent; nucleus; protein binding; cytosol; cytoplasm;
TFAP2A	5	negative regulation of transcription, DNA-dependent; nucleus; protein binding; cytoplasm; nucleolus;
WWP1	5	negative regulation of transcription, DNA-dependent; nucleus; protein binding; cytosol; cytoplasm;
XRCC5	5	negative regulation of transcription, DNA-dependent; nucleus; protein binding; cytoplasm; nucleolus;
AATF	5	nucleus; protein binding; apoptotic process; cytoplasm; nucleolus;
AIP	5	nucleus; protein binding; cytosol; cytoplasm; nucleolus;
APC	5	nucleus; protein binding; apoptotic process; cytosol; cytoplasm;
BAIAP2	5	nucleus; protein binding; cytosol; cytoplasm; nucleolus;
CEP164	5	nucleus; protein binding; cytosol; cytoplasm; nucleolus;
CEP57	5	nucleus; protein binding; cytosol; cytoplasm; nucleolus;
EGLN3	5	nucleus; protein binding; apoptotic process; cytosol; cytoplasm;
FUS	5	nucleus; protein binding; RNA binding; cytoplasm; nucleolus;
GZMB	5	nucleus; protein binding; apoptotic process; cytosol; cytoplasm;
HNRNPA2B1	5	nucleus; protein binding; RNA binding; cytoplasm; nucleolus;
HNRNPH1	5	nucleus; protein binding; RNA binding; cytoplasm; nucleolus;
IARS	5	nucleus; protein binding; cytosol; cytoplasm; nucleolus;
IGF2BP3	5	nucleus; protein binding; RNA binding; cytosol; cytoplasm;
MALT1	5	nucleus; protein binding; cytosol; cytoplasm; nucleolus;
MAPK3	5	nucleus; protein binding; apoptotic process; cytosol; nucleolus;
MPHOSPH6	5	nucleus; protein binding; RNA binding; cytoplasm; nucleolus;
NOL8	5	nucleus; protein binding; RNA binding; cytoplasm; nucleolus;
NUMA1	5	nucleus; protein binding; cytosol; cytoplasm; nucleolus;
PAFAH1B1	5	nucleus; protein binding; cytosol; cytoplasm; nucleolus;
PPP1CA	5	nucleus; protein binding; cytosol; cytoplasm; nucleolus;
PRKCB	5	nucleus; protein binding; apoptotic process; cytosol; cytoplasm;
PRKD1	5	nucleus; protein binding; apoptotic process; cytosol; cytoplasm;
PSPC1	5	nucleus; protein binding; RNA binding; cytoplasm; nucleolus;
RBM4	5	nucleus; protein binding; RNA binding; cytoplasm; nucleolus;
RFWD2	5	nucleus; protein binding; cytosol; cytoplasm; nucleolus;
SART1	5	nucleus; protein binding; cytosol; cytoplasm; nucleolus;
SMNDC1	5	nucleus; protein binding; RNA binding; apoptotic process; cytoplasm;
STXBP3	5	nucleus; protein binding; cytosol; cytoplasm; nucleolus;
TJP1	5	nucleus; protein binding; apoptotic process; cytosol; cytoplasm;
WWOX	5	nucleus; protein binding; apoptotic process; cytosol; cytoplasm;
ZFR	5	nucleus; protein binding; RNA binding; cytoplasm; nucleolus;

Genes shared at least 2 KEGG pathways with PDCD4 (count: 0)

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Region: chr10:112631565..112659764 View in gBrowse