ADHDgene Database

Gene Report

Basic Info

Approved Symbol	IGF2BP3
Symbol Alias	IMP-3, CT98
Approved Name	insulin-like growth factor 2 mRNA binding protein 3
Name Alias	IGF II mRNA binding protein 3, "cancer/testis antigen 98"
Location	7p15.3
Position	chr7:23349828-23510086, -
External Links	HGNC: 28868 Entrez Gene: 10643 Ensembl: ENSG00000136231 UCSC: uc003swg.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Lesch[2011]_6	chr7:23010000-26070000 (NCBI Build 35 (hg17))	3060000	7p15.2-7p15.3	Duplication	Paternal (affected)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
7p15	chr7:20900000-28800000	2 (1/1/0)

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0009653	anatomical structure morphogenesis	Biological Process	TAS[9891060]	26
GO:0017148	negative regulation of translation	Biological Process	ISS[9891060]	5
GO:0005829	cytosol	Cellular Component		447
GO:0006412	translation	Biological Process	TAS[9891060]	42
GO:0048027	mRNA 5'-UTR binding	Molecular Function	IDA[9891060]	1
GO:0042035	regulation of cytokine biosynthetic process	Biological Process	IC[9891060]	4
GO:0045182	translation regulator activity	Molecular Function	ISS[9891060]	2
GO:0003723	RNA binding	Molecular Function	TAS[9891060]	104
GO:0000166	nucleotide binding	Molecular Function		73
GO:0005515	protein binding	Molecular Function	IPI[17289661]	910
GO:0003730	mRNA 3'-UTR binding	Molecular Function		7
GO:0005737	cytoplasm	Cellular Component		690
GO:0005634	nucleus	Cellular Component		770

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with IGF2BP3 (count: 17)

Gene Symbol	Pathway Count	Pathway List
RBM4	7	negative regulation of translation; RNA binding; nucleotide binding; protein binding; mRNA 3'-UTR binding; cytoplasm; nucleus;
TH	5	anatomical structure morphogenesis; cytosol; protein binding; cytoplasm; nucleus;
ALKBH8	5	cytosol; RNA binding; protein binding; cytoplasm; nucleus;
PDCD4	5	cytosol; RNA binding; protein binding; cytoplasm; nucleus;
RPL14	5	cytosol; translation; RNA binding; protein binding; cytoplasm;
RPS3	5	cytosol; translation; protein binding; cytoplasm; nucleus;
RPS9	5	cytosol; translation; translation regulator activity; protein binding; cytoplasm;
WWOX	5	cytosol; nucleotide binding; protein binding; cytoplasm; nucleus;
IGHMBP2	5	translation; RNA binding; protein binding; cytoplasm; nucleus;
CELF1	5	RNA binding; nucleotide binding; protein binding; cytoplasm; nucleus;
FUS	5	RNA binding; nucleotide binding; protein binding; cytoplasm; nucleus;
HNRNPA2B1	5	RNA binding; nucleotide binding; protein binding; cytoplasm; nucleus;
HNRNPH1	5	RNA binding; nucleotide binding; protein binding; cytoplasm; nucleus;
NOL8	5	RNA binding; nucleotide binding; protein binding; cytoplasm; nucleus;
PSPC1	5	RNA binding; nucleotide binding; protein binding; cytoplasm; nucleus;
RBFOX1	5	RNA binding; nucleotide binding; protein binding; cytoplasm; nucleus;
TARDBP	5	RNA binding; nucleotide binding; protein binding; mRNA 3'-UTR binding; nucleus;

Genes shared at least 2 KEGG pathways with IGF2BP3 (count: 0)

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Region: chr7:23349828..23510086 View in gBrowse