ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FUS
Previous Symbol	ALS6
Symbol Alias	TLS, FUS1, hnRNP-P2
Approved Name	fused in sarcoma
Previous Name	fusion, derived from t(12;16) malignant liposarcoma, "amyotrophic lateral sclerosis 6", "fusion (involved in t(12;16) in malignant liposarcoma)"
Name Alias	heterogeneous nuclear ribonucleoprotein P2, "translocated in liposarcoma"
Location	16p11.2
Position	chr16:31191431-31206192, +
External Links	HGNC: 4010 Entrez Gene: 2521 Ensembl: ENSG00000089280 UCSC: uc002ebf.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_34	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813248	16p11.2	Loss	De novo
CNV_Williams[2010]_39	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813247	16p11.2	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	No. of Genes in ADHDgene
GO:0000166	nucleotide binding	Molecular Function	73
GO:0000398	mRNA splicing, via spliceosome	Biological Process	54
GO:0003677	DNA binding	Molecular Function	220
GO:0003723	RNA binding	Molecular Function	104
GO:0005515	protein binding	Molecular Function	910
GO:0005634	nucleus	Cellular Component	770
GO:0005730	nucleolus	Cellular Component	243
GO:0005654	nucleoplasm	Cellular Component	183
GO:0008219	cell death	Biological Process	33
GO:0005737	cytoplasm	Cellular Component	690
GO:0008380	RNA splicing	Biological Process	65
GO:0008270	zinc ion binding	Molecular Function	323
GO:0010467	gene expression	Biological Process	140

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with FUS (count: 123)

Gene Symbol	Pathway Count	Pathway List
HNRNPA2B1	10	nucleotide binding; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm; RNA splicing; gene expression;
HNRNPH1	10	nucleotide binding; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm; RNA splicing; gene expression;
U2AF1	10	nucleotide binding; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleus; nucleolus; nucleoplasm; RNA splicing; zinc ion binding; gene expression;
HNRNPA1	9	nucleotide binding; mRNA splicing, via spliceosome; RNA binding; nucleus; nucleolus; nucleoplasm; cytoplasm; RNA splicing; gene expression;
RBM4	9	nucleotide binding; RNA binding; protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm; RNA splicing; zinc ion binding;
DHX9	9	mRNA splicing, via spliceosome; DNA binding; protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm; RNA splicing; gene expression;
CPSF7	8	nucleotide binding; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleus; nucleoplasm; RNA splicing; gene expression;
EFTUD2	8	mRNA splicing, via spliceosome; protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm; RNA splicing; gene expression;
NCBP1	8	mRNA splicing, via spliceosome; DNA binding; RNA binding; protein binding; nucleus; nucleoplasm; RNA splicing; gene expression;
SF3A1	8	mRNA splicing, via spliceosome; RNA binding; protein binding; nucleus; nucleolus; nucleoplasm; RNA splicing; gene expression;
SF3A3	8	mRNA splicing, via spliceosome; protein binding; nucleus; nucleolus; nucleoplasm; RNA splicing; zinc ion binding; gene expression;
SMC1A	8	mRNA splicing, via spliceosome; protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm; RNA splicing; gene expression;
PGR	8	DNA binding; protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm; zinc ion binding; gene expression;
HNRNPC	7	nucleotide binding; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression;
SF3B4	7	nucleotide binding; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression;
SNRPA	7	nucleotide binding; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression;
TARDBP	7	nucleotide binding; RNA binding; protein binding; nucleus; nucleolus; cell death; RNA splicing;
U2AF2	7	nucleotide binding; mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression;
CD2BP2	7	mRNA splicing, via spliceosome; protein binding; nucleus; nucleoplasm; cytoplasm; RNA splicing; gene expression;
DDX23	7	mRNA splicing, via spliceosome; protein binding; nucleus; nucleolus; nucleoplasm; RNA splicing; gene expression;
PRPF4	7	mRNA splicing, via spliceosome; protein binding; nucleus; nucleolus; nucleoplasm; RNA splicing; gene expression;
PRPF6	7	mRNA splicing, via spliceosome; RNA binding; protein binding; nucleus; nucleoplasm; RNA splicing; gene expression;
SNRNP200	7	mRNA splicing, via spliceosome; protein binding; nucleus; nucleolus; nucleoplasm; RNA splicing; gene expression;
SNRPD1	7	mRNA splicing, via spliceosome; RNA binding; protein binding; nucleus; nucleoplasm; RNA splicing; gene expression;
ATXN1	7	DNA binding; protein binding; nucleus; nucleolus; nucleoplasm; cell death; cytoplasm;
IGHMBP2	7	DNA binding; RNA binding; protein binding; nucleus; cell death; cytoplasm; zinc ion binding;
RBPJ	7	DNA binding; protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm; gene expression;
SSRP1	7	DNA binding; protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm; gene expression;
ZFR	7	DNA binding; RNA binding; protein binding; nucleus; nucleolus; cytoplasm; zinc ion binding;
CHD1L	6	nucleotide binding; DNA binding; protein binding; nucleus; nucleolus; cytoplasm;
NOL8	6	nucleotide binding; RNA binding; protein binding; nucleus; nucleolus; cytoplasm;
PSPC1	6	nucleotide binding; RNA binding; protein binding; nucleus; nucleolus; cytoplasm;
RBFOX1	6	nucleotide binding; RNA binding; protein binding; nucleus; cytoplasm; RNA splicing;
SNRPB2	6	nucleotide binding; mRNA splicing, via spliceosome; protein binding; nucleoplasm; RNA splicing; gene expression;
CPSF3	6	mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression;
DHX8	6	mRNA splicing, via spliceosome; RNA binding; protein binding; nucleus; nucleolus; RNA splicing;
POLR2G	6	mRNA splicing, via spliceosome; RNA binding; nucleus; nucleoplasm; RNA splicing; gene expression;
PRPF8	6	mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression;
SART1	6	mRNA splicing, via spliceosome; protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm;
SF3B2	6	mRNA splicing, via spliceosome; nucleus; nucleolus; nucleoplasm; RNA splicing; gene expression;
SNRPA1	6	mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression;
SNRPG	6	mRNA splicing, via spliceosome; RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression;
SNW1	6	mRNA splicing, via spliceosome; protein binding; nucleus; nucleolus; nucleoplasm; gene expression;
ESRRA	6	DNA binding; protein binding; nucleus; nucleoplasm; zinc ion binding; gene expression;
HINFP	6	DNA binding; protein binding; nucleus; nucleolus; nucleoplasm; zinc ion binding;
MAPK1	6	DNA binding; protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm;
NCOR2	6	DNA binding; protein binding; nucleus; nucleolus; nucleoplasm; gene expression;
NR5A1	6	DNA binding; protein binding; nucleus; nucleoplasm; zinc ion binding; gene expression;
TAF13	6	DNA binding; protein binding; nucleus; nucleolus; nucleoplasm; gene expression;
TAF4B	6	DNA binding; nucleus; nucleolus; nucleoplasm; cytoplasm; gene expression;
XRCC5	6	DNA binding; protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm;
ATXN2	6	RNA binding; protein binding; nucleus; nucleolus; cell death; cytoplasm;
XPO1	6	RNA binding; protein binding; nucleolus; nucleoplasm; cytoplasm; gene expression;
DGCR8	6	protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm; gene expression;
MEN1	6	protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm; gene expression;
NR4A2	6	protein binding; nucleus; nucleoplasm; cytoplasm; zinc ion binding; gene expression;
RFWD2	6	protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm; zinc ion binding;
CELF1	5	nucleotide binding; RNA binding; protein binding; nucleus; cytoplasm;
IGF2BP3	5	nucleotide binding; RNA binding; protein binding; nucleus; cytoplasm;
LARP7	5	nucleotide binding; RNA binding; nucleus; nucleoplasm; cytoplasm;
POLE	5	nucleotide binding; DNA binding; nucleus; nucleoplasm; zinc ion binding;
RBM14	5	nucleotide binding; RNA binding; protein binding; nucleus; nucleolus;
RBM4B	5	nucleotide binding; RNA binding; nucleolus; RNA splicing; zinc ion binding;
SCAF8	5	nucleotide binding; RNA binding; nucleus; nucleolus; RNA splicing;
SETD1A	5	nucleotide binding; RNA binding; protein binding; nucleus; nucleolus;
ZCRB1	5	nucleotide binding; RNA binding; nucleoplasm; RNA splicing; zinc ion binding;
ZRSR2	5	nucleotide binding; mRNA splicing, via spliceosome; protein binding; RNA splicing; zinc ion binding;
PHF5A	5	mRNA splicing, via spliceosome; DNA binding; nucleoplasm; RNA splicing; gene expression;
PRPF19	5	mRNA splicing, via spliceosome; DNA binding; protein binding; nucleus; cytoplasm;
SF1	5	mRNA splicing, via spliceosome; RNA binding; nucleus; nucleolus; zinc ion binding;
SF3A2	5	mRNA splicing, via spliceosome; nucleoplasm; RNA splicing; zinc ion binding; gene expression;
SLU7	5	mRNA splicing, via spliceosome; nucleus; nucleolus; cytoplasm; zinc ion binding;
SNRPB	5	mRNA splicing, via spliceosome; protein binding; nucleoplasm; RNA splicing; gene expression;
SNRPD2	5	mRNA splicing, via spliceosome; protein binding; nucleoplasm; RNA splicing; gene expression;
SNRPD3	5	mRNA splicing, via spliceosome; protein binding; nucleoplasm; RNA splicing; gene expression;
SNRPF	5	mRNA splicing, via spliceosome; RNA binding; nucleoplasm; RNA splicing; gene expression;
TXNL4A	5	mRNA splicing, via spliceosome; protein binding; nucleoplasm; RNA splicing; gene expression;
BCLAF1	5	DNA binding; protein binding; nucleus; nucleolus; cytoplasm;
DDB1	5	DNA binding; protein binding; nucleus; nucleoplasm; cytoplasm;
DEAF1	5	DNA binding; protein binding; nucleus; cytoplasm; zinc ion binding;
E2F5	5	DNA binding; protein binding; nucleoplasm; cytoplasm; gene expression;
FEN1	5	DNA binding; protein binding; nucleus; nucleolus; nucleoplasm;
IRF7	5	DNA binding; protein binding; nucleus; nucleoplasm; cytoplasm;
MRE11A	5	DNA binding; protein binding; nucleus; nucleolus; nucleoplasm;
NR4A3	5	DNA binding; nucleus; nucleoplasm; zinc ion binding; gene expression;
POLA2	5	DNA binding; nucleus; nucleolus; nucleoplasm; cytoplasm;
POLR1A	5	DNA binding; protein binding; nucleoplasm; zinc ion binding; gene expression;
RELA	5	DNA binding; protein binding; nucleus; nucleoplasm; cytoplasm;
TCF25	5	DNA binding; protein binding; nucleus; nucleolus; cytoplasm;
TNFAIP3	5	DNA binding; protein binding; nucleus; cytoplasm; zinc ion binding;
ZFPM1	5	DNA binding; protein binding; nucleoplasm; cytoplasm; zinc ion binding;
ZNF263	5	DNA binding; nucleus; nucleolus; cytoplasm; zinc ion binding;
ZNF367	5	DNA binding; nucleus; nucleolus; cytoplasm; zinc ion binding;
ZNF74	5	DNA binding; RNA binding; nucleus; nucleolus; zinc ion binding;
ZNF77	5	DNA binding; nucleus; nucleolus; cytoplasm; zinc ion binding;
ALKBH8	5	RNA binding; protein binding; nucleus; nucleolus; cytoplasm;
BARD1	5	RNA binding; protein binding; nucleus; cytoplasm; zinc ion binding;
MPHOSPH6	5	RNA binding; protein binding; nucleus; nucleolus; cytoplasm;
PDCD4	5	RNA binding; protein binding; nucleus; nucleolus; cytoplasm;
SMNDC1	5	RNA binding; protein binding; nucleus; cytoplasm; RNA splicing;
TRIM32	5	RNA binding; protein binding; nucleus; cytoplasm; zinc ion binding;
BNIP3	5	protein binding; nucleus; nucleoplasm; cell death; cytoplasm;
DCPS	5	protein binding; nucleus; nucleolus; cytoplasm; gene expression;
HSPA8	5	protein binding; nucleus; nucleolus; RNA splicing; gene expression;
IARS	5	protein binding; nucleus; nucleolus; cytoplasm; gene expression;
MAML1	5	protein binding; nucleus; nucleolus; nucleoplasm; gene expression;
MAPK3	5	protein binding; nucleus; nucleolus; nucleoplasm; gene expression;
MED1	5	protein binding; nucleus; nucleolus; nucleoplasm; gene expression;
MED4	5	protein binding; nucleus; nucleolus; nucleoplasm; gene expression;
NCOR1	5	protein binding; nucleus; nucleoplasm; cytoplasm; gene expression;
NEDD4L	5	protein binding; nucleus; nucleoplasm; cytoplasm; gene expression;
NUMA1	5	protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm;
PARK2	5	protein binding; nucleus; cell death; cytoplasm; zinc ion binding;
PSMC3	5	protein binding; nucleus; nucleoplasm; cytoplasm; gene expression;
RAD23B	5	protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm;
RAD9A	5	protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm;
RCC1	5	protein binding; nucleus; nucleolus; nucleoplasm; cytoplasm;
RCHY1	5	protein binding; nucleus; nucleolus; cytoplasm; zinc ion binding;
RNF40	5	protein binding; nucleus; nucleolus; cytoplasm; zinc ion binding;
TAF10	5	protein binding; nucleus; nucleoplasm; cytoplasm; gene expression;
TRIM5	5	protein binding; nucleus; nucleolus; cytoplasm; zinc ion binding;
YAP1	5	protein binding; nucleus; nucleoplasm; cytoplasm; gene expression;
ZMAT5	5	nucleus; nucleolus; cytoplasm; RNA splicing; zinc ion binding;

Genes shared at least 2 KEGG pathways with FUS (count: 0)

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Region: chr16:31191431..31206192 View in gBrowse