ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TXNL4A
Previous Symbol	TXNL4
Symbol Alias	U5-15kD, DIM1, HsT161, DIB1
Approved Name	thioredoxin-like 4A
Previous Name	thioredoxin-like 4
Name Alias	similar to S. pombe dim1+
Location	18q23
Position	chr18:77732867-77748532, -
External Links	HGNC: 30551 Entrez Gene: 10907 Ensembl: ENSG00000141759 UCSC: uc002lnp.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component	TAS[10610776]	51

GO terms by database search (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051301	cell division	Biological Process		58
GO:0008380	RNA splicing	Biological Process		65
GO:0010467	gene expression	Biological Process		140
GO:0000375	RNA splicing, via transesterification reactions	Biological Process	TAS[10610776]	11
GO:0000398	mRNA splicing, via spliceosome	Biological Process		54
GO:0000245	spliceosomal complex assembly	Biological Process	TAS[10610776]	8
GO:0007067	mitosis	Biological Process		39
GO:0005515	protein binding	Molecular Function	IPI[15840814]	910
GO:0005654	nucleoplasm	Cellular Component		183

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with TXNL4A (count: 39)

Gene Symbol	Pathway Count	Pathway List
PRPF6	8	RNA splicing; gene expression; RNA splicing, via transesterification reactions; mRNA splicing, via spliceosome; spliceosomal complex assembly; spliceosomal complex; protein binding; nucleoplasm;
DDX23	7	RNA splicing; gene expression; RNA splicing, via transesterification reactions; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
PRPF4	7	RNA splicing; gene expression; RNA splicing, via transesterification reactions; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
PRPF8	7	RNA splicing; gene expression; RNA splicing, via transesterification reactions; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
SF3A3	7	RNA splicing; gene expression; RNA splicing, via transesterification reactions; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
SF3B4	7	RNA splicing; gene expression; RNA splicing, via transesterification reactions; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
SNRPD2	7	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex assembly; spliceosomal complex; protein binding; nucleoplasm;
SNRPG	7	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex assembly; spliceosomal complex; protein binding; nucleoplasm;
SMC1A	6	cell division; RNA splicing; gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm;
EFTUD2	6	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
HNRNPA2B1	6	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
HNRNPC	6	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
SF3A1	6	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
SF3B3	6	RNA splicing; gene expression; RNA splicing, via transesterification reactions; mRNA splicing, via spliceosome; spliceosomal complex; nucleoplasm;
SNRNP200	6	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
SNRPA	6	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
SNRPA1	6	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
SNRPB	6	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
SNRPB2	6	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
SNRPD1	6	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex assembly; protein binding; nucleoplasm;
SNRPD3	6	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
U2AF1	6	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
U2AF2	6	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;
RAN	5	cell division; gene expression; mitosis; protein binding; nucleoplasm;
CD2BP2	5	RNA splicing; gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm;
CDC40	5	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; nucleoplasm;
CPSF3	5	RNA splicing; gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm;
CPSF7	5	RNA splicing; gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm;
DHX9	5	RNA splicing; gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm;
FUS	5	RNA splicing; gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm;
HNRNPA1	5	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; nucleoplasm;
HNRNPH1	5	RNA splicing; gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm;
NCBP1	5	RNA splicing; gene expression; mRNA splicing, via spliceosome; protein binding; nucleoplasm;
PHF5A	5	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; nucleoplasm;
SF3A2	5	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; nucleoplasm;
SF3B2	5	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; nucleoplasm;
SNRPF	5	RNA splicing; gene expression; mRNA splicing, via spliceosome; spliceosomal complex; nucleoplasm;
ZRSR2	5	RNA splicing; mRNA splicing, via spliceosome; spliceosomal complex assembly; spliceosomal complex; protein binding;
SNW1	5	gene expression; mRNA splicing, via spliceosome; spliceosomal complex; protein binding; nucleoplasm;

Genes shared at least 2 KEGG pathways with TXNL4A (count: 0)

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Region: chr18:77732867..77748532 View in gBrowse