ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SF3B2
Symbol Alias	SAP145, SF3b1, Cus1, SF3b145
Approved Name	splicing factor 3b, subunit 2, 145kDa
Previous Name	splicing factor 3b, subunit 2, 145kD
Location	11q13
Position	chr11:65818200-65836779, +
External Links	HGNC: 10769 Entrez Gene: 10992 Ensembl: ENSG00000087365 UCSC: uc001ogy.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component	IDA[9731529]	51

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005634	nucleus	Cellular Component		770
GO:0003676	nucleic acid binding	Molecular Function		41
GO:0008380	RNA splicing	Biological Process		65
GO:0006397	mRNA processing	Biological Process	TAS[8566756]	50
GO:0005730	nucleolus	Cellular Component		243
GO:0005689	U12-type spliceosomal complex	Cellular Component	IDA[15146077]	16
GO:0010467	gene expression	Biological Process		140
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[9731529]	54
GO:0019048	virus-host interaction	Biological Process		54
GO:0071013	catalytic step 2 spliceosome	Cellular Component	IDA[11991638]	31

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with SF3B2 (count: 51)

Gene Symbol	Pathway Count	Pathway List
HNRNPA1	10	spliceosomal complex; nucleoplasm; nucleus; RNA splicing; mRNA processing; nucleolus; gene expression; mRNA splicing, via spliceosome; virus-host interaction; catalytic step 2 spliceosome;
SF3A3	10	spliceosomal complex; nucleoplasm; nucleus; nucleic acid binding; RNA splicing; mRNA processing; nucleolus; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
DDX23	9	spliceosomal complex; nucleoplasm; nucleus; nucleic acid binding; RNA splicing; nucleolus; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
EFTUD2	9	spliceosomal complex; nucleoplasm; nucleus; RNA splicing; mRNA processing; nucleolus; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
HNRNPA2B1	9	spliceosomal complex; nucleoplasm; nucleus; RNA splicing; mRNA processing; nucleolus; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SF3A1	9	spliceosomal complex; nucleoplasm; nucleus; RNA splicing; mRNA processing; nucleolus; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SF3B3	9	spliceosomal complex; nucleoplasm; nucleic acid binding; RNA splicing; mRNA processing; U12-type spliceosomal complex; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRNP200	9	spliceosomal complex; nucleoplasm; nucleus; nucleic acid binding; RNA splicing; nucleolus; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
U2AF1	9	spliceosomal complex; nucleoplasm; nucleus; RNA splicing; mRNA processing; nucleolus; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SF3A2	8	spliceosomal complex; nucleoplasm; nucleic acid binding; RNA splicing; mRNA processing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRPB	8	spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; U12-type spliceosomal complex; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRPD3	8	spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; U12-type spliceosomal complex; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRPF	8	spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; U12-type spliceosomal complex; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRPG	8	spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; U12-type spliceosomal complex; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNW1	8	spliceosomal complex; nucleoplasm; nucleus; nucleolus; gene expression; mRNA splicing, via spliceosome; virus-host interaction; catalytic step 2 spliceosome;
DHX15	7	spliceosomal complex; nucleus; nucleic acid binding; RNA splicing; mRNA processing; nucleolus; U12-type spliceosomal complex;
HSPA8	7	spliceosomal complex; nucleus; RNA splicing; mRNA processing; nucleolus; gene expression; virus-host interaction;
PRPF4	7	spliceosomal complex; nucleoplasm; nucleus; RNA splicing; nucleolus; gene expression; mRNA splicing, via spliceosome;
PRPF6	7	spliceosomal complex; nucleoplasm; nucleus; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
PRPF8	7	spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SF3B4	7	spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; U12-type spliceosomal complex; gene expression; mRNA splicing, via spliceosome;
SNRPB2	7	spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRPD2	7	spliceosomal complex; nucleoplasm; RNA splicing; U12-type spliceosomal complex; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
ZMAT5	7	spliceosomal complex; nucleus; nucleic acid binding; RNA splicing; mRNA processing; nucleolus; U12-type spliceosomal complex;
HNRNPH1	7	nucleoplasm; nucleus; RNA splicing; nucleolus; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRPD1	7	nucleoplasm; nucleus; RNA splicing; U12-type spliceosomal complex; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
CDC40	6	spliceosomal complex; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
DHX8	6	spliceosomal complex; nucleus; RNA splicing; nucleolus; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
HNRNPC	6	spliceosomal complex; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
PHF5A	6	spliceosomal complex; nucleoplasm; RNA splicing; U12-type spliceosomal complex; gene expression; mRNA splicing, via spliceosome;
SNRPA1	6	spliceosomal complex; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
U2AF2	6	spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; gene expression; mRNA splicing, via spliceosome;
CPSF7	6	nucleoplasm; nucleus; RNA splicing; mRNA processing; gene expression; mRNA splicing, via spliceosome;
DHX9	6	nucleoplasm; nucleus; RNA splicing; nucleolus; gene expression; mRNA splicing, via spliceosome;
FUS	6	nucleoplasm; nucleus; RNA splicing; nucleolus; gene expression; mRNA splicing, via spliceosome;
NCBP1	6	nucleoplasm; nucleus; RNA splicing; mRNA processing; gene expression; mRNA splicing, via spliceosome;
SMC1A	6	nucleoplasm; nucleus; RNA splicing; nucleolus; gene expression; mRNA splicing, via spliceosome;
SCAF8	5	spliceosomal complex; nucleus; RNA splicing; mRNA processing; nucleolus;
SF1	5	spliceosomal complex; nucleus; nucleic acid binding; nucleolus; mRNA splicing, via spliceosome;
SLU7	5	spliceosomal complex; nucleus; nucleolus; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRPA	5	spliceosomal complex; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome;
TXNL4A	5	spliceosomal complex; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome;
ZCRB1	5	spliceosomal complex; nucleoplasm; RNA splicing; mRNA processing; U12-type spliceosomal complex;
CD2BP2	5	nucleoplasm; nucleus; RNA splicing; gene expression; mRNA splicing, via spliceosome;
CLP1	5	nucleoplasm; RNA splicing; mRNA processing; gene expression; mRNA splicing, via spliceosome;
CPSF3	5	nucleoplasm; RNA splicing; mRNA processing; gene expression; mRNA splicing, via spliceosome;
MAPK3	5	nucleoplasm; nucleus; nucleolus; gene expression; virus-host interaction;
PCF11	5	nucleoplasm; RNA splicing; mRNA processing; gene expression; mRNA splicing, via spliceosome;
POLR2G	5	nucleoplasm; nucleus; RNA splicing; gene expression; mRNA splicing, via spliceosome;
RBM4	5	nucleoplasm; nucleus; RNA splicing; mRNA processing; nucleolus;
SART1	5	nucleoplasm; nucleus; nucleolus; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;

Genes shared at least 2 KEGG pathways with SF3B2 (count: 0)

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Region: chr11:65818200..65836779 View in gBrowse