ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PCF11
Symbol Alias	KIAA0824
Approved Name	PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)
Previous Name	PCF11, cleavage and polyadenylation factor II subunit, homolog (S. cerevisiae)
Location	11q13
Position	chr11:82868030-82898493, +
External Links	HGNC: 30097 Entrez Gene: 51585 Ensembl: ENSG00000165494 UCSC: uc001ozx.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0010467	gene expression	Biological Process		140
GO:0008380	RNA splicing	Biological Process		65
GO:0031124	mRNA 3'-end processing	Biological Process		8
GO:0006369	termination of RNA polymerase II transcription	Biological Process		14
GO:0006366	transcription from RNA polymerase II promoter	Biological Process		62
GO:0006397	mRNA processing	Biological Process		50
GO:0006379	mRNA cleavage	Biological Process	NAS[11060040]	4
GO:0000398	mRNA splicing, via spliceosome	Biological Process		54
GO:0005849	mRNA cleavage factor complex	Cellular Component	NAS[11060040]	2
GO:0005654	nucleoplasm	Cellular Component		183

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03015	mRNA surveillance pathway	17	The mRNA surveillance pathway is a quality control mechanism...... The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins. More...

Genes shared at least 5 GO terms with PCF11 (count: 24)

Gene Symbol	Pathway Count	Pathway List
CPSF3	9	gene expression; RNA splicing; mRNA 3'-end processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; mRNA processing; mRNA cleavage; mRNA splicing, via spliceosome; nucleoplasm;
CPSF7	9	gene expression; RNA splicing; mRNA 3'-end processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; mRNA processing; mRNA splicing, via spliceosome; mRNA cleavage factor complex; nucleoplasm;
NCBP1	9	gene expression; RNA splicing; mRNA 3'-end processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; mRNA processing; mRNA cleavage; mRNA splicing, via spliceosome; nucleoplasm;
CLP1	8	gene expression; RNA splicing; mRNA 3'-end processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
U2AF1	8	gene expression; RNA splicing; mRNA 3'-end processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
U2AF2	8	gene expression; RNA splicing; mRNA 3'-end processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
CDC40	7	gene expression; RNA splicing; mRNA 3'-end processing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; mRNA splicing, via spliceosome; nucleoplasm;
SNRPB	7	gene expression; RNA splicing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
SNRPD3	7	gene expression; RNA splicing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
SNRPF	7	gene expression; RNA splicing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
SNRPG	7	gene expression; RNA splicing; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
EFTUD2	5	gene expression; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
HNRNPA1	5	gene expression; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
HNRNPA2B1	5	gene expression; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
LSM11	5	gene expression; termination of RNA polymerase II transcription; transcription from RNA polymerase II promoter; mRNA processing; nucleoplasm;
POLR2G	5	gene expression; RNA splicing; transcription from RNA polymerase II promoter; mRNA splicing, via spliceosome; nucleoplasm;
PRPF8	5	gene expression; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
SF3A1	5	gene expression; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
SF3A2	5	gene expression; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
SF3A3	5	gene expression; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
SF3B2	5	gene expression; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
SF3B3	5	gene expression; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
SF3B4	5	gene expression; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;
SNRPB2	5	gene expression; RNA splicing; mRNA processing; mRNA splicing, via spliceosome; nucleoplasm;

Genes shared at least 2 KEGG pathways with PCF11 (count: 0)

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Region: chr11:82868030..82898493 View in gBrowse