ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CDC40
Symbol Alias	PRP17, EHB3, PRPF17, FLJ10564
Approved Name	cell division cycle 40 homolog (S. cerevisiae)
Previous Name	cell division cycle 40 homolog (yeast)
Location	6q22.1
Position	chr6:110501344-110575478, +
External Links	HGNC: 17350 Entrez Gene: 51362 Ensembl: ENSG00000168438 UCSC: uc003pua.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component	TAS[9524131]	51

GO terms by database search (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006406	mRNA export from nucleus	Biological Process		12
GO:0008380	RNA splicing	Biological Process		65
GO:0010467	gene expression	Biological Process		140
GO:0031124	mRNA 3'-end processing	Biological Process		8
GO:0005654	nucleoplasm	Cellular Component		183
GO:0006366	transcription from RNA polymerase II promoter	Biological Process		62
GO:0006369	termination of RNA polymerase II transcription	Biological Process		14
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[11991638]	54
GO:0071013	catalytic step 2 spliceosome	Cellular Component	IDA[11991638]	31

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with CDC40 (count: 36)

Gene Symbol	Pathway Count	Pathway List
U2AF1	10	mRNA export from nucleus; RNA splicing; gene expression; mRNA 3'-end processing; nucleoplasm; spliceosomal complex; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
U2AF2	9	mRNA export from nucleus; RNA splicing; gene expression; mRNA 3'-end processing; nucleoplasm; spliceosomal complex; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA splicing, via spliceosome;
CPSF3	8	mRNA export from nucleus; RNA splicing; gene expression; mRNA 3'-end processing; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA splicing, via spliceosome;
NCBP1	8	mRNA export from nucleus; RNA splicing; gene expression; mRNA 3'-end processing; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA splicing, via spliceosome;
SNRPB	8	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRPD3	8	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRPF	8	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRPG	8	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
CLP1	7	RNA splicing; gene expression; mRNA 3'-end processing; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA splicing, via spliceosome;
CPSF7	7	RNA splicing; gene expression; mRNA 3'-end processing; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA splicing, via spliceosome;
PCF11	7	RNA splicing; gene expression; mRNA 3'-end processing; nucleoplasm; transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription; mRNA splicing, via spliceosome;
DDX23	6	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
EFTUD2	6	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
HNRNPA1	6	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
HNRNPA2B1	6	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
HNRNPC	6	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
PRPF6	6	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
PRPF8	6	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SF3A1	6	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SF3A2	6	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SF3A3	6	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SF3B2	6	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SF3B3	6	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRNP200	6	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRPA1	6	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRPB2	6	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRPD2	6	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
HNRNPH1	5	RNA splicing; gene expression; nucleoplasm; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
PHF5A	5	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome;
POLR2G	5	RNA splicing; gene expression; nucleoplasm; transcription from RNA polymerase II promoter; mRNA splicing, via spliceosome;
PRPF4	5	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome;
SF3B4	5	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome;
SNRPA	5	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome;
SNRPD1	5	RNA splicing; gene expression; nucleoplasm; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
TXNL4A	5	RNA splicing; gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome;
SNW1	5	gene expression; nucleoplasm; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;

Genes shared at least 2 KEGG pathways with CDC40 (count: 0)

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Region: chr6:110501344..110575478 View in gBrowse