ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SNRPD1
Previous Symbol	SNRPD
Symbol Alias	HsT2456, Sm-D1
Approved Name	small nuclear ribonucleoprotein D1 polypeptide 16kDa
Previous Name	small nuclear ribonucleoprotein D1 polypeptide (16kD)
Location	18q11.2
Position	chr18:19192260-19210208, +
External Links	HGNC: 11158 Entrez Gene: 6632 Ensembl: ENSG00000167088 UCSC: uc002ktj.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
18q11.2-12.3	chr18:19000000-43500000	1 (1/0/0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003723	RNA binding	Molecular Function	TAS[3260384]	104
GO:0005515	protein binding	Molecular Function	IPI[18984161]	910
GO:0005634	nucleus	Cellular Component	TAS[3260384]	770
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005689	U12-type spliceosomal complex	Cellular Component	IDA[15146077]	16
GO:0005829	cytosol	Cellular Component		447
GO:0008380	RNA splicing	Biological Process		65
GO:0010467	gene expression	Biological Process		140
GO:0000245	spliceosomal complex assembly	Biological Process	TAS[7527560]	8
GO:0000387	spliceosomal snRNP assembly	Biological Process		10
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[11991638]	54
GO:0071013	catalytic step 2 spliceosome	Cellular Component	IDA[11991638]	31
GO:0034660	ncRNA metabolic process	Biological Process		8
GO:0030532	small nuclear ribonucleoprotein complex	Cellular Component	TAS[7527560]	12
GO:0016070	RNA metabolic process	Biological Process		46

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...
hsa05322	Systemic lupus erythematosus	19	Systemic lupus erythematosus (SLE) is a prototypic autoimmun...... Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components, in association with a diverse array of clinical manifestations. The primary pathological findings in patients with SLE are those of inflammation, vasculitis, immune complex deposition, and vasculopathy. Immune complexes comprising autoantibody and self-antigen is deposited particulary in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc{gamma}R-mediated neutrophil and macrophage activation. Activation of complement (C5) leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases. More...

Genes shared at least 5 GO terms with SNRPD1 (count: 69)

Gene Symbol	Pathway Count	Pathway List
SNRPG	14	RNA binding; protein binding; nucleoplasm; U12-type spliceosomal complex; cytosol; RNA splicing; gene expression; spliceosomal complex assembly; spliceosomal snRNP assembly; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; ncRNA metabolic process; small nuclear ribonucleoprotein complex; RNA metabolic process;
SNRPD2	13	protein binding; nucleoplasm; U12-type spliceosomal complex; cytosol; RNA splicing; gene expression; spliceosomal complex assembly; spliceosomal snRNP assembly; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; ncRNA metabolic process; small nuclear ribonucleoprotein complex; RNA metabolic process;
SNRPF	12	RNA binding; nucleoplasm; U12-type spliceosomal complex; cytosol; RNA splicing; gene expression; spliceosomal snRNP assembly; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; ncRNA metabolic process; small nuclear ribonucleoprotein complex; RNA metabolic process;
SNRPB	12	protein binding; nucleoplasm; U12-type spliceosomal complex; cytosol; RNA splicing; gene expression; spliceosomal snRNP assembly; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; ncRNA metabolic process; small nuclear ribonucleoprotein complex; RNA metabolic process;
SNRPD3	12	protein binding; nucleoplasm; U12-type spliceosomal complex; cytosol; RNA splicing; gene expression; spliceosomal snRNP assembly; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; ncRNA metabolic process; small nuclear ribonucleoprotein complex; RNA metabolic process;
NCBP1	11	RNA binding; protein binding; nucleus; nucleoplasm; cytosol; RNA splicing; gene expression; spliceosomal snRNP assembly; mRNA splicing, via spliceosome; ncRNA metabolic process; RNA metabolic process;
PRPF6	9	RNA binding; protein binding; nucleus; nucleoplasm; RNA splicing; gene expression; spliceosomal complex assembly; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
HNRNPA2B1	8	RNA binding; protein binding; nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
HNRNPH1	8	RNA binding; protein binding; nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SF3A1	8	RNA binding; protein binding; nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRPA1	8	RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; small nuclear ribonucleoprotein complex;
U2AF1	8	RNA binding; protein binding; nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
CPSF7	7	RNA binding; protein binding; nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome;
FUS	7	RNA binding; protein binding; nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome;
HNRNPA1	7	RNA binding; nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
HNRNPC	7	RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
LSM4	7	RNA binding; protein binding; cytosol; RNA splicing; gene expression; small nuclear ribonucleoprotein complex; RNA metabolic process;
PRPF8	7	RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SF3B4	7	RNA binding; protein binding; nucleoplasm; U12-type spliceosomal complex; RNA splicing; gene expression; mRNA splicing, via spliceosome;
CLNS1A	7	protein binding; nucleus; cytosol; gene expression; spliceosomal snRNP assembly; ncRNA metabolic process; RNA metabolic process;
DDX23	7	protein binding; nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
EFTUD2	7	protein binding; nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SART1	7	protein binding; nucleus; nucleoplasm; cytosol; spliceosomal snRNP assembly; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SF3A3	7	protein binding; nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNRNP200	7	protein binding; nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SF3B2	7	nucleus; nucleoplasm; U12-type spliceosomal complex; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SF3B3	7	nucleoplasm; U12-type spliceosomal complex; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; small nuclear ribonucleoprotein complex;
CNOT6	6	RNA binding; protein binding; nucleus; cytosol; gene expression; RNA metabolic process;
CPSF3	6	RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome;
DHX8	6	RNA binding; protein binding; nucleus; RNA splicing; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
POLR2G	6	RNA binding; nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome;
SNRPA	6	RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome;
U2AF2	6	RNA binding; protein binding; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome;
XPO1	6	RNA binding; protein binding; nucleoplasm; cytosol; gene expression; RNA metabolic process;
CD2BP2	6	protein binding; nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome;
DHX9	6	protein binding; nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome;
HSPA8	6	protein binding; nucleus; cytosol; RNA splicing; gene expression; RNA metabolic process;
PRPF4	6	protein binding; nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome;
PSMC3	6	protein binding; nucleus; nucleoplasm; cytosol; gene expression; RNA metabolic process;
SMC1A	6	protein binding; nucleus; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome;
SNRPB2	6	protein binding; nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SNW1	6	protein binding; nucleus; nucleoplasm; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
TXNL4A	6	protein binding; nucleoplasm; RNA splicing; gene expression; spliceosomal complex assembly; mRNA splicing, via spliceosome;
SF3A2	6	nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome; small nuclear ribonucleoprotein complex;
CWC15	5	RNA binding; protein binding; nucleus; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
DDX6	5	RNA binding; protein binding; cytosol; gene expression; RNA metabolic process;
PATL1	5	RNA binding; protein binding; cytosol; gene expression; RNA metabolic process;
PDCD4	5	RNA binding; protein binding; nucleus; cytosol; RNA metabolic process;
RBM4	5	RNA binding; protein binding; nucleus; nucleoplasm; RNA splicing;
RPL13	5	RNA binding; protein binding; cytosol; gene expression; RNA metabolic process;
RPL14	5	RNA binding; protein binding; cytosol; gene expression; RNA metabolic process;
DCPS	5	protein binding; nucleus; cytosol; gene expression; RNA metabolic process;
MAPK3	5	protein binding; nucleus; nucleoplasm; cytosol; gene expression;
MEN1	5	protein binding; nucleus; nucleoplasm; cytosol; gene expression;
NEDD4L	5	protein binding; nucleus; nucleoplasm; cytosol; gene expression;
PRPF19	5	protein binding; nucleus; spliceosomal complex assembly; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
PSMB7	5	protein binding; nucleoplasm; cytosol; gene expression; RNA metabolic process;
PSMD5	5	protein binding; nucleoplasm; cytosol; gene expression; RNA metabolic process;
PSMD7	5	protein binding; nucleoplasm; cytosol; gene expression; RNA metabolic process;
RPS3	5	protein binding; nucleus; cytosol; gene expression; RNA metabolic process;
RQCD1	5	protein binding; nucleus; cytosol; gene expression; RNA metabolic process;
SMG1	5	protein binding; nucleus; cytosol; gene expression; RNA metabolic process;
SMG7	5	protein binding; nucleus; cytosol; gene expression; RNA metabolic process;
UBB	5	protein binding; nucleoplasm; cytosol; gene expression; RNA metabolic process;
UBC	5	protein binding; nucleoplasm; cytosol; gene expression; RNA metabolic process;
YAP1	5	protein binding; nucleus; nucleoplasm; cytosol; gene expression;
ZRSR2	5	protein binding; U12-type spliceosomal complex; RNA splicing; spliceosomal complex assembly; mRNA splicing, via spliceosome;
CDC40	5	nucleoplasm; RNA splicing; gene expression; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
PHF5A	5	nucleoplasm; U12-type spliceosomal complex; RNA splicing; gene expression; mRNA splicing, via spliceosome;

Genes shared at least 2 KEGG pathways with SNRPD1 (count: 2)

Gene Symbol	Pathway Count	Pathway List
SNRPB	2	Spliceosome; Systemic lupus erythematosus;
SNRPD3	2	Spliceosome; Systemic lupus erythematosus;

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Region: chr18:19192260..19210208 View in gBrowse