Gene Report
Basic Info
Approved Symbol |
PRPF19
|
Previous Symbol |
PRP19 |
Symbol Alias |
UBOX4, NMP200, PSO4, hPSO4 |
Approved Name |
PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) |
Previous Name |
PRP19/PSO4 homolog (S. cerevisiae) |
Name Alias |
nuclear matrix protein NMP200 related to splicing factor PRP19 |
Location |
11q12.2 |
Position |
chr11:60658019-60674061, - |
External Links |
HGNC: 17896
Entrez Gene: 27339
Ensembl: ENSG00000110107
UCSC: uc001nqf.2
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 22)
Gene related KEGG pathways (count: 2)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa03040 |
Spliceosome |
47 |
After transcription, eukaryotic mRNA precursors contain prot......
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
More...
|
hsa04120 |
Ubiquitin mediated proteolysis |
29 |
Protein ubiquitination plays an important role in eukaryotic......
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
More...
|
Genes shared at least 5 GO terms with PRPF19 (count: 45)
Gene Symbol |
Pathway Count |
Pathway List |
PRPF6 |
6 |
spliceosomal complex assembly;
mRNA splicing, via spliceosome;
protein binding;
nucleus;
catalytic step 2 spliceosome;
nuclear speck;
|
EFTUD2 |
6 |
mRNA splicing, via spliceosome;
cytoplasm;
protein binding;
nucleus;
catalytic step 2 spliceosome;
nuclear speck;
|
BARD1 |
6 |
ubiquitin ligase complex;
DNA repair;
cytoplasm;
protein binding;
nucleus;
ubiquitin-protein ligase activity;
|
RCHY1 |
6 |
ubiquitin ligase complex;
cytoplasm;
protein binding;
nucleus;
ubiquitin-protein ligase activity;
nuclear speck;
|
SNRPD1 |
5 |
spliceosomal complex assembly;
mRNA splicing, via spliceosome;
protein binding;
nucleus;
catalytic step 2 spliceosome;
|
CD2BP2 |
5 |
mRNA splicing, via spliceosome;
cytoplasm;
protein binding;
nucleus;
nuclear speck;
|
DHX9 |
5 |
mRNA splicing, via spliceosome;
cytoplasm;
protein binding;
nucleus;
DNA binding;
|
FUS |
5 |
mRNA splicing, via spliceosome;
cytoplasm;
protein binding;
nucleus;
DNA binding;
|
HNRNPA2B1 |
5 |
mRNA splicing, via spliceosome;
cytoplasm;
protein binding;
nucleus;
catalytic step 2 spliceosome;
|
HNRNPH1 |
5 |
mRNA splicing, via spliceosome;
cytoplasm;
protein binding;
nucleus;
catalytic step 2 spliceosome;
|
SART1 |
5 |
mRNA splicing, via spliceosome;
cytoplasm;
protein binding;
nucleus;
catalytic step 2 spliceosome;
|
SF3A3 |
5 |
mRNA splicing, via spliceosome;
protein binding;
nucleus;
catalytic step 2 spliceosome;
nuclear speck;
|
SLU7 |
5 |
mRNA splicing, via spliceosome;
cytoplasm;
nucleus;
catalytic step 2 spliceosome;
nuclear speck;
|
SMC1A |
5 |
mRNA splicing, via spliceosome;
DNA repair;
cytoplasm;
protein binding;
nucleus;
|
SNW1 |
5 |
mRNA splicing, via spliceosome;
protein binding;
nucleus;
catalytic step 2 spliceosome;
positive regulation of mRNA splicing, via spliceosome;
|
U2AF1 |
5 |
mRNA splicing, via spliceosome;
protein binding;
nucleus;
catalytic step 2 spliceosome;
nuclear speck;
|
FBXO4 |
5 |
ubiquitin ligase complex;
protein polyubiquitination;
cytoplasm;
protein binding;
ubiquitin-protein ligase activity;
|
FBXO7 |
5 |
ubiquitin ligase complex;
cytoplasm;
protein binding;
nucleus;
ubiquitin-protein ligase activity;
|
RNF20 |
5 |
ubiquitin ligase complex;
protein polyubiquitination;
protein binding;
nucleus;
ubiquitin-protein ligase activity;
|
RNF40 |
5 |
ubiquitin ligase complex;
cytoplasm;
protein binding;
nucleus;
ubiquitin-protein ligase activity;
|
UBE4A |
5 |
ubiquitin ligase complex;
protein polyubiquitination;
cytoplasm;
protein binding;
ubiquitin-ubiquitin ligase activity;
|
WWP1 |
5 |
ubiquitin ligase complex;
cytoplasm;
protein binding;
nucleus;
ubiquitin-protein ligase activity;
|
ERCC8 |
5 |
protein polyubiquitination;
DNA repair;
protein binding;
nucleus;
ubiquitin-protein ligase activity;
|
PARK2 |
5 |
protein polyubiquitination;
cytoplasm;
protein binding;
nucleus;
ubiquitin-protein ligase activity;
|
TRIM32 |
5 |
protein polyubiquitination;
cytoplasm;
protein binding;
nucleus;
ubiquitin-protein ligase activity;
|
KIF22 |
5 |
spindle;
DNA repair;
cytoplasm;
nucleus;
DNA binding;
|
MAP1S |
5 |
spindle;
protein binding;
nucleus;
DNA binding;
identical protein binding;
|
MAPK1 |
5 |
spindle;
cytoplasm;
protein binding;
nucleus;
DNA binding;
|
MMS19 |
5 |
spindle;
DNA repair;
cytoplasm;
protein binding;
nucleus;
|
PRC1 |
5 |
spindle;
cytoplasm;
protein binding;
nucleus;
identical protein binding;
|
CHD1L |
5 |
DNA repair;
cytoplasm;
protein binding;
nucleus;
DNA binding;
|
DDB1 |
5 |
DNA repair;
cytoplasm;
protein binding;
nucleus;
DNA binding;
|
HERC2 |
5 |
DNA repair;
cytoplasm;
protein binding;
nucleus;
ubiquitin-protein ligase activity;
|
IGHMBP2 |
5 |
DNA repair;
cytoplasm;
protein binding;
nucleus;
DNA binding;
|
SSRP1 |
5 |
DNA repair;
cytoplasm;
protein binding;
nucleus;
DNA binding;
|
TRIP12 |
5 |
DNA repair;
cytoplasm;
protein binding;
nucleus;
ubiquitin-protein ligase activity;
|
XRCC5 |
5 |
DNA repair;
cytoplasm;
protein binding;
nucleus;
DNA binding;
|
APBB1 |
5 |
cytoplasm;
protein binding;
nucleus;
negative regulation of neuron differentiation;
nuclear speck;
|
ATXN1 |
5 |
cytoplasm;
protein binding;
nucleus;
DNA binding;
identical protein binding;
|
HES1 |
5 |
cytoplasm;
protein binding;
nucleus;
DNA binding;
positive regulation of astrocyte differentiation;
|
ID2 |
5 |
cytoplasm;
protein binding;
nucleus;
positive regulation of astrocyte differentiation;
negative regulation of neuron differentiation;
|
RELA |
5 |
cytoplasm;
protein binding;
nucleus;
DNA binding;
identical protein binding;
|
TNFAIP3 |
5 |
cytoplasm;
protein binding;
nucleus;
DNA binding;
ubiquitin-protein ligase activity;
|
TRIM5 |
5 |
cytoplasm;
protein binding;
nucleus;
ubiquitin-protein ligase activity;
identical protein binding;
|
ZBTB16 |
5 |
protein binding;
nucleus;
DNA binding;
identical protein binding;
nuclear speck;
|
Genes shared at least 2 KEGG pathways with PRPF19 (count: 0)
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