ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MMS19
Previous Symbol	MMS19L
Symbol Alias	MET18, hMMS19
Approved Name	MMS19 nucleotide excision repair homolog (S. cerevisiae)
Name Alias	MET18 homolog (S. cerevisiae)
Location	10q24-q25
Position	chr10:99218081-99258551, -
External Links	HGNC: 13824 Entrez Gene: 64210 Ensembl: ENSG00000155229 UCSC: uc001kns.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 22)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005737	cytoplasm	Cellular Component		690
GO:0005675	holo TFIIH complex	Cellular Component	NAS[11279242]	2
GO:0005634	nucleus	Cellular Component	TAS[11071939]	770
GO:0005515	protein binding	Molecular Function		910
GO:0006289	nucleotide-excision repair	Biological Process	NAS[11279242]; TAS[11071939]	12
GO:0006281	DNA repair	Biological Process		62
GO:0006259	DNA metabolic process	Biological Process		4
GO:0005819	spindle	Cellular Component		29
GO:0009725	response to hormone stimulus	Biological Process	NAS[11279242]	11
GO:0007059	chromosome segregation	Biological Process		14
GO:0006974	response to DNA damage stimulus	Biological Process		37
GO:0006351	transcription, DNA-dependent	Biological Process	NAS[11071939]	247
GO:0030674	protein binding, bridging	Molecular Function	NAS[11279242]	11
GO:0030331	estrogen receptor binding	Molecular Function	IPI[11279242]	10
GO:0030159	receptor signaling complex scaffold activity	Molecular Function	NAS[11279242]	8
GO:0016226	iron-sulfur cluster assembly	Biological Process		2
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IMP[11279242]	80
GO:0071817	MMXD complex	Cellular Component		2
GO:0097361	CIA complex	Cellular Component		2
GO:0000160	phosphorelay signal transduction system	Biological Process	NAS[11279242]	1
GO:0003713	transcription coactivator activity	Molecular Function	IMP[11279242]	52

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MMS19 (count: 36)

Gene Symbol	Pathway Count	Pathway List
NCOA6	9	nucleus; protein binding; DNA repair; response to hormone stimulus; response to DNA damage stimulus; estrogen receptor binding; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; transcription coactivator activity;
MAPK1	7	cytoplasm; nucleus; protein binding; spindle; response to DNA damage stimulus; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent;
MEN1	7	cytoplasm; nucleus; protein binding; DNA repair; response to DNA damage stimulus; transcription, DNA-dependent; protein binding, bridging;
SMARCD3	7	cytoplasm; nucleus; protein binding; transcription, DNA-dependent; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; transcription coactivator activity;
NRIP1	7	nucleus; protein binding; transcription, DNA-dependent; estrogen receptor binding; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; transcription coactivator activity;
APBB1	6	cytoplasm; nucleus; protein binding; response to DNA damage stimulus; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent;
NUP62	6	cytoplasm; protein binding; transcription, DNA-dependent; receptor signaling complex scaffold activity; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent;
TP53BP1	6	cytoplasm; nucleus; protein binding; DNA repair; response to DNA damage stimulus; positive regulation of transcription, DNA-dependent;
TRIP12	6	cytoplasm; nucleus; protein binding; DNA repair; response to DNA damage stimulus; nuclear hormone receptor binding;
HINFP	6	nucleus; protein binding; DNA repair; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; transcription coactivator activity;
MED1	6	nucleus; protein binding; estrogen receptor binding; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; transcription coactivator activity;
BARD1	5	cytoplasm; nucleus; protein binding; DNA repair; response to DNA damage stimulus;
CHD1L	5	cytoplasm; nucleus; protein binding; DNA repair; response to DNA damage stimulus;
DAXX	5	cytoplasm; nucleus; protein binding; transcription, DNA-dependent; nuclear hormone receptor binding;
DDB1	5	cytoplasm; nucleus; protein binding; nucleotide-excision repair; DNA repair;
FANCC	5	cytoplasm; nucleus; protein binding; nucleotide-excision repair; DNA repair;
HERC2	5	cytoplasm; nucleus; protein binding; DNA repair; response to DNA damage stimulus;
IGHMBP2	5	cytoplasm; nucleus; protein binding; DNA repair; transcription, DNA-dependent;
IRF7	5	cytoplasm; nucleus; protein binding; response to DNA damage stimulus; positive regulation of transcription, DNA-dependent;
PRPF19	5	cytoplasm; nucleus; protein binding; DNA repair; spindle;
PTTG1	5	cytoplasm; nucleus; protein binding; DNA repair; chromosome segregation;
RAD23B	5	cytoplasm; nucleus; protein binding; nucleotide-excision repair; DNA repair;
RAD9A	5	cytoplasm; nucleus; protein binding; DNA repair; response to DNA damage stimulus;
RAN	5	cytoplasm; protein binding; DNA metabolic process; positive regulation of transcription, DNA-dependent; transcription coactivator activity;
TAF10	5	cytoplasm; nucleus; protein binding; estrogen receptor binding; transcription coactivator activity;
TFAP2A	5	cytoplasm; nucleus; protein binding; positive regulation of transcription, DNA-dependent; transcription coactivator activity;
TGFB1I1	5	cytoplasm; protein binding; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; transcription coactivator activity;
XRCC5	5	cytoplasm; nucleus; protein binding; DNA repair; transcription, DNA-dependent;
YAP1	5	cytoplasm; nucleus; protein binding; response to DNA damage stimulus; transcription coactivator activity;
ERCC8	5	nucleus; protein binding; nucleotide-excision repair; DNA repair; response to DNA damage stimulus;
HMGA1	5	nucleus; protein binding; transcription, DNA-dependent; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent;
KAT5	5	nucleus; protein binding; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; transcription coactivator activity;
NPAT	5	nucleus; protein binding; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; transcription coactivator activity;
NSD1	5	nucleus; transcription, DNA-dependent; estrogen receptor binding; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent;
RBM14	5	nucleus; protein binding; DNA repair; response to hormone stimulus; protein binding, bridging;
THRAP3	5	nucleus; protein binding; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; transcription coactivator activity;

Genes shared at least 2 KEGG pathways with MMS19 (count: 0)

View in gBrowse

Region: chr10:99218081..99258551 View in gBrowse