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- Data Summary
GO Report
Basic Info
| ID | GO:0035257 |
|---|---|
| Name | nuclear hormone receptor binding |
| Type | molecular function |
| No. of Genes in ADHDgene | 5 |
| Source | Pathway by PBA (with statistical significance of FDR<0.05) |
PBA Result (with statistical significance of FDR<0.05)
| Data Set Reference | Gene Set | Mapping Rule | P-value | FDR | Result Link |
|---|---|---|---|---|---|
| Neale BM, 2008 | MsigDB 3.0 c5.mf | 500kb upstream and downstream of gene | 0.004 | 0.04475 | Link |
Comments for this pathway (count: 1)
| PMID | Citation | Comment |
|---|---|---|
| 15579758 | Vermiglio F, Lo Presti VP, et al.Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: A possible novel iodine deficiency disorder in developed countries. J Clin Endocrinol Metab 2004, 89(12):6054-6060. | So far, a similar prevalence of ADHD has been reported only ...... So far, a similar prevalence of ADHD has been reported only in children with generalized resistance to thyroid hormones. This might suggest a common ADHD pathogenetic mechanism consisting either of reduced sensitivity of the nuclear receptors to thyroid hormone ( generalized resistance to thyroid hormones) or reduced availability of intracellular T-3 for nuclear receptor binding. More... |
GO related genes in ADHDgene (count: 5)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 5)
| Approved Symbol | Approved Name | Source | Evidence[PMID] |
|---|---|---|---|
| NCOA7 | nuclear receptor coactivator 7 | Mapped by significant region | IDA[11971969] |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | Mapped by PBA pathway | IDA[15207008] |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | Mapped by PBA pathway | IPI[14701856] |
| SNW1 | SNW domain containing 1 | Mapped by PBA pathway | IDA[19934264] |
| NRIP1 | nuclear receptor interacting protein 1 | Mapped by PBA pathway | IPI[11518808] |