ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0035257
Name nuclear hormone receptor binding
Type Molecular Function
No. of Genes in ADHDgene  30
Source Pathway by PBA (with statistical significance of FDR<0.05)

PBA Result (with statistical significance of FDR<0.05)
Data Set Reference Gene Set Mapping Rule P-value FDR Result Link
Neale BM, 2008 MsigDB 3.0 c5.mf 500kb upstream and downstream of gene 0.004 0.04475 Link

Comments for this pathway (count: 1)
PMID Citation Comment
15579758 Vermiglio F, Lo Presti VP, et al.Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: A possible novel iodine deficiency disorder in developed countries. J Clin Endocrinol Metab 2004, 89(12):6054-6060. So far, a similar prevalence of ADHD has been reported only ...... So far, a similar prevalence of ADHD has been reported only in children with generalized resistance to thyroid hormones. This might suggest a common ADHD pathogenetic mechanism consisting either of reduced sensitivity of the nuclear receptors to thyroid hormone ( generalized resistance to thyroid hormones) or reduced availability of intracellular T-3 for nuclear receptor binding. More...

GO related genes in ADHDgene (count: 30)

Literature-origin genes (count: 0)

Genes from other sources Help (count: 30)

Approved Symbol Approved Name Source Evidence[PMID]
HMGA1 high mobility group AT-hook 1 Mapped by PBA pathway
MED1 mediator complex subunit 1 Mapped by LD-proxy; Mapped by PBA pathway
NCOA6 nuclear receptor coactivator 6 Mapped by PBA pathway
MED14 mediator complex subunit 14 Mapped by PBA pathway
TGFB1I1 transforming growth factor beta 1 induced transcript 1 Mapped by PBA pathway
JMJD1C jumonji domain containing 1C Mapped by PBA pathway
TACC2 transforming, acidic coiled-coil containing protein 2 Mapped by PBA pathway IDA[15207008]
MED13 mediator complex subunit 13 Mapped by PBA pathway
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 Mapped by PBA pathway
MED24 mediator complex subunit 24 Mapped by PBA pathway
NRIP1 nuclear receptor interacting protein 1 Mapped by PBA pathway IPI[11518808]
MED17 mediator complex subunit 17 Mapped by PBA pathway; Mapped by significant region
PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) Mapped by PBA pathway
NCOA7 nuclear receptor coactivator 7 Mapped by significant region IDA[11971969]
NSD1 nuclear receptor binding SET domain protein 1 Mapped by PBA pathway
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta Mapped by PBA pathway
DAXX death-domain associated protein Mapped by LD-proxy; Mapped by PBA pathway
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Mapped by PBA pathway IPI[14701856]
THRAP3 thyroid hormone receptor associated protein 3 Mapped by PBA pathway
NUP62 nucleoporin 62kDa Mapped by PBA pathway
MED4 mediator complex subunit 4 Mapped by PBA pathway
MED12 mediator complex subunit 12 Mapped by PBA pathway
MED30 mediator complex subunit 30 Mapped by PBA pathway
SNW1 SNW domain containing 1 Mapped by PBA pathway IDA[19934264]
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide Mapped by PBA pathway
OASL 2'-5'-oligoadenylate synthetase-like Mapped by PBA pathway
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) Mapped by PBA pathway
TRIP12 thyroid hormone receptor interactor 12 Mapped by PBA pathway
ZNHIT3 zinc finger, HIT-type containing 3 Mapped by CNV; Mapped by PBA pathway
MED16 mediator complex subunit 16 Mapped by PBA pathway

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014