ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0035257
Name nuclear hormone receptor binding
Type molecular function
No. of Genes in ADHDgene  5
Source Pathway by PBA (with statistical significance of FDR<0.05)

PBA Result (with statistical significance of FDR<0.05)
Data Set Reference Gene Set Mapping Rule P-value FDR Result Link
Neale BM, 2008 MsigDB 3.0 c5.mf 500kb upstream and downstream of gene 0.004 0.04475 Link

Comments for this pathway (count: 1)
PMID Citation Comment
15579758 Vermiglio F, Lo Presti VP, et al.Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: A possible novel iodine deficiency disorder in developed countries. J Clin Endocrinol Metab 2004, 89(12):6054-6060. So far, a similar prevalence of ADHD has been reported only ...... So far, a similar prevalence of ADHD has been reported only in children with generalized resistance to thyroid hormones. This might suggest a common ADHD pathogenetic mechanism consisting either of reduced sensitivity of the nuclear receptors to thyroid hormone ( generalized resistance to thyroid hormones) or reduced availability of intracellular T-3 for nuclear receptor binding. More...

GO related genes in ADHDgene (count: 5)

Literature-origin genes (count: 0)

Genes from other sources Help (count: 5)

Approved Symbol Approved Name Source Evidence[PMID]
NCOA7 nuclear receptor coactivator 7 Mapped by significant region IDA[11971969]
TACC2 transforming, acidic coiled-coil containing protein 2 Mapped by PBA pathway IDA[15207008]
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Mapped by PBA pathway IPI[14701856]
SNW1 SNW domain containing 1 Mapped by PBA pathway IDA[19934264]
NRIP1 nuclear receptor interacting protein 1 Mapped by PBA pathway IPI[11518808]