ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MED12
Previous Symbol	TNRC11, FGS1
Symbol Alias	CAGH45, HOPA, OPA1, TRAP230, KIAA0192, OKS
Approved Name	mediator complex subunit 12
Previous Name	trinucleotide repeat containing 11 (THR-associated protein, 230kDa subunit), "mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae)", "FG syndrome 1"
Location	Xq13
Position	chrX:70338406-70362304, +
External Links	HGNC: 11957 Entrez Gene: 9968 Ensembl: ENSG00000184634 UCSC: uc004dyy.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 28)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0060070	canonical Wnt receptor signaling pathway	Biological Process		13
GO:0060071	Wnt receptor signaling pathway, planar cell polarity pathway	Biological Process		3
GO:0090245	axis elongation involved in somitogenesis	Biological Process		1
GO:0019827	stem cell maintenance	Biological Process		12
GO:0016592	mediator complex	Cellular Component	IDA[12037571]	17
GO:0030178	negative regulation of Wnt receptor signaling pathway	Biological Process	IMP[17000779]	8
GO:0019904	protein domain specific binding	Molecular Function	IPI[11984006]	40
GO:0008013	beta-catenin binding	Molecular Function		10
GO:0007507	heart development	Biological Process		23
GO:0010467	gene expression	Biological Process		140
GO:0008022	protein C-terminus binding	Molecular Function	IPI[17000779]	32
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[10198638]	80
GO:0042809	vitamin D receptor binding	Molecular Function	NAS[10235266]	11
GO:0046966	thyroid hormone receptor binding	Molecular Function	IDA[10198638]	18
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[12037571]	131
GO:0030518	intracellular steroid hormone receptor signaling pathway	Biological Process	IDA[11867769]	10
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Molecular Function	NAS[10235266]	19
GO:0030521	androgen receptor signaling pathway	Biological Process	IDA[12218053]	16
GO:0001104	RNA polymerase II transcription cofactor activity	Molecular Function	IDA[10198638]	16
GO:0005654	nucleoplasm	Cellular Component		183
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	IDA[12218053]	42
GO:0004872	receptor activity	Molecular Function	IDA[12218053]	36
GO:0005634	nucleus	Cellular Component	IDA[17000779]	770
GO:0003712	transcription cofactor activity	Molecular Function	IDA[12218053]	17
GO:0003713	transcription coactivator activity	Molecular Function	IDA[12037571]	52
GO:0001843	neural tube closure	Biological Process		10
GO:0003682	chromatin binding	Molecular Function		48

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MED12 (count: 42)

Gene Symbol	Pathway Count	Pathway List
MED14	18	stem cell maintenance; mediator complex; gene expression; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway; RNA polymerase II transcription cofactor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter; receptor activity; nucleus; transcription cofactor activity; transcription coactivator activity;
MED17	18	stem cell maintenance; mediator complex; gene expression; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway; RNA polymerase II transcription cofactor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter; receptor activity; nucleus; transcription cofactor activity; transcription coactivator activity;
MED1	18	mediator complex; gene expression; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway; RNA polymerase II transcription cofactor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter; receptor activity; nucleus; transcription cofactor activity; transcription coactivator activity; chromatin binding;
MED13	17	mediator complex; gene expression; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway; RNA polymerase II transcription cofactor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter; receptor activity; nucleus; transcription cofactor activity; transcription coactivator activity;
MED24	16	stem cell maintenance; mediator complex; gene expression; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway; RNA polymerase II transcription cofactor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter; receptor activity; nucleus; transcription cofactor activity;
MED30	16	stem cell maintenance; mediator complex; gene expression; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway; RNA polymerase II transcription cofactor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter; receptor activity; nucleus; transcription cofactor activity;
MED4	15	mediator complex; gene expression; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway; RNA polymerase II transcription cofactor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter; receptor activity; nucleus; transcription cofactor activity;
THRAP3	15	mediator complex; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; intracellular steroid hormone receptor signaling pathway; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; androgen receptor signaling pathway; RNA polymerase II transcription cofactor activity; transcription initiation from RNA polymerase II promoter; receptor activity; nucleus; transcription cofactor activity; transcription coactivator activity;
MED16	14	mediator complex; gene expression; positive regulation of transcription, DNA-dependent; vitamin D receptor binding; thyroid hormone receptor binding; intracellular steroid hormone receptor signaling pathway; nuclear hormone receptor binding; androgen receptor signaling pathway; nucleoplasm; transcription initiation from RNA polymerase II promoter; receptor activity; nucleus; transcription cofactor activity; transcription coactivator activity;
NCOA6	11	heart development; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; positive regulation of transcription from RNA polymerase II promoter; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; nucleus; transcription coactivator activity; chromatin binding;
SNW1	8	gene expression; vitamin D receptor binding; positive regulation of transcription from RNA polymerase II promoter; nuclear hormone receptor binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; nucleus; transcription coactivator activity;
MED15	7	stem cell maintenance; mediator complex; gene expression; RNA polymerase II transcription cofactor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter; nucleus;
MED7	7	stem cell maintenance; mediator complex; gene expression; RNA polymerase II transcription cofactor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter; transcription coactivator activity;
NR5A1	7	gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription initiation from RNA polymerase II promoter; nucleus; transcription coactivator activity; chromatin binding;
YAP1	7	gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription initiation from RNA polymerase II promoter; nucleus; transcription coactivator activity; chromatin binding;
PPARGC1B	6	mediator complex; positive regulation of transcription from RNA polymerase II promoter; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; RNA polymerase II transcription cofactor activity; nucleus;
ESRRA	6	protein domain specific binding; gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription initiation from RNA polymerase II promoter; nucleus;
MAML1	6	gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription initiation from RNA polymerase II promoter; nucleus; transcription coactivator activity;
MAML2	6	gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription initiation from RNA polymerase II promoter; nucleus; transcription coactivator activity;
MEN1	6	gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription initiation from RNA polymerase II promoter; nucleus; chromatin binding;
NCOR1	6	gene expression; thyroid hormone receptor binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; nucleus; chromatin binding;
PRPF6	6	gene expression; positive regulation of transcription from RNA polymerase II promoter; nuclear hormone receptor binding; nucleoplasm; nucleus; transcription coactivator activity;
RAN	6	gene expression; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; nucleoplasm; transcription coactivator activity; chromatin binding;
NRIP1	6	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nuclear hormone receptor binding; androgen receptor signaling pathway; nucleus; transcription coactivator activity;
NSD1	6	positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; nuclear hormone receptor binding; nucleus; transcription cofactor activity; chromatin binding;
SMARCD3	6	positive regulation of transcription, DNA-dependent; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; nucleoplasm; nucleus; transcription coactivator activity;
BCL9L	5	canonical Wnt receptor signaling pathway; beta-catenin binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription coactivator activity;
SMC1A	5	stem cell maintenance; gene expression; nucleoplasm; nucleus; chromatin binding;
MED23	5	mediator complex; gene expression; nucleoplasm; transcription initiation from RNA polymerase II promoter; transcription coactivator activity;
RBM14	5	mediator complex; positive regulation of transcription from RNA polymerase II promoter; ligand-dependent nuclear receptor transcription coactivator activity; RNA polymerase II transcription cofactor activity; nucleus;
NCOR2	5	gene expression; nucleoplasm; transcription initiation from RNA polymerase II promoter; nucleus; chromatin binding;
NR4A2	5	gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription initiation from RNA polymerase II promoter; nucleus;
RBPJ	5	gene expression; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription initiation from RNA polymerase II promoter; nucleus;
TAF10	5	gene expression; nucleoplasm; transcription initiation from RNA polymerase II promoter; nucleus; transcription coactivator activity;
TAF13	5	gene expression; protein C-terminus binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; nucleus;
HINFP	5	positive regulation of transcription, DNA-dependent; nucleoplasm; nucleus; transcription coactivator activity; chromatin binding;
HMGA1	5	positive regulation of transcription, DNA-dependent; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; nucleoplasm; nucleus;
KAT5	5	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; androgen receptor signaling pathway; nucleus; transcription coactivator activity;
RELA	5	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; chromatin binding;
TFAP2A	5	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription coactivator activity; chromatin binding;
TP53BP1	5	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; RNA polymerase II transcription cofactor activity; nucleoplasm; nucleus;
KDM1A	5	positive regulation of transcription from RNA polymerase II promoter; ligand-dependent nuclear receptor transcription coactivator activity; nucleoplasm; nucleus; chromatin binding;

Genes shared at least 2 KEGG pathways with MED12 (count: 0)

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Region: chrX:70338406..70362304 View in gBrowse