ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MED16
Previous Symbol	THRAP5
Symbol Alias	DRIP92, TRAP95
Approved Name	mediator complex subunit 16
Previous Name	thyroid hormone receptor associated protein 5
Location	19p13.3
Position	chr19:867962-893218, -
External Links	HGNC: 17556 Entrez Gene: 10025 Ensembl: ENSG00000175221 UCSC: uc002lqd.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0046966	thyroid hormone receptor binding	Molecular Function	IDA[10198638]	18
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	TAS[10198638]	62
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	IDA[12218053]	42
GO:0005654	nucleoplasm	Cellular Component		183
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	NAS[10198638]	42
GO:0004872	receptor activity	Molecular Function	IDA[12218053]	36
GO:0005634	nucleus	Cellular Component	NAS[10198638]	770
GO:0003712	transcription cofactor activity	Molecular Function	IDA[12218053]	17
GO:0003713	transcription coactivator activity	Molecular Function	TAS[10198638]	52
GO:0042809	vitamin D receptor binding	Molecular Function	NAS[10235266]	11
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[10198638]	80
GO:0030521	androgen receptor signaling pathway	Biological Process	IDA[12218053]	16
GO:0030375	thyroid hormone receptor coactivator activity	Molecular Function	IDA[10198638]	2
GO:0030518	intracellular steroid hormone receptor signaling pathway	Biological Process	IDA[11867769]	10
GO:0010467	gene expression	Biological Process		140
GO:0016592	mediator complex	Cellular Component	IDA[10198638]	17

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MED16 (count: 30)

Gene Symbol	Pathway Count	Pathway List
MED1	15	thyroid hormone receptor binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; receptor activity; nucleus; transcription cofactor activity; transcription coactivator activity; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; nuclear hormone receptor binding; thyroid hormone receptor coactivator activity; intracellular steroid hormone receptor signaling pathway; gene expression; mediator complex;
MED14	15	thyroid hormone receptor binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; regulation of transcription from RNA polymerase II promoter; receptor activity; nucleus; transcription cofactor activity; transcription coactivator activity; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; nuclear hormone receptor binding; intracellular steroid hormone receptor signaling pathway; gene expression; mediator complex;
MED17	15	thyroid hormone receptor binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; regulation of transcription from RNA polymerase II promoter; receptor activity; nucleus; transcription cofactor activity; transcription coactivator activity; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; nuclear hormone receptor binding; intracellular steroid hormone receptor signaling pathway; gene expression; mediator complex;
MED12	14	thyroid hormone receptor binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; receptor activity; nucleus; transcription cofactor activity; transcription coactivator activity; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; nuclear hormone receptor binding; intracellular steroid hormone receptor signaling pathway; gene expression; mediator complex;
MED13	14	thyroid hormone receptor binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; receptor activity; nucleus; transcription cofactor activity; transcription coactivator activity; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; nuclear hormone receptor binding; intracellular steroid hormone receptor signaling pathway; gene expression; mediator complex;
MED4	14	thyroid hormone receptor binding; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; receptor activity; nucleus; transcription cofactor activity; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; nuclear hormone receptor binding; intracellular steroid hormone receptor signaling pathway; gene expression; mediator complex;
MED24	13	thyroid hormone receptor binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; receptor activity; nucleus; transcription cofactor activity; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; nuclear hormone receptor binding; intracellular steroid hormone receptor signaling pathway; gene expression; mediator complex;
MED30	13	thyroid hormone receptor binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; receptor activity; nucleus; transcription cofactor activity; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; nuclear hormone receptor binding; intracellular steroid hormone receptor signaling pathway; gene expression; mediator complex;
THRAP3	12	thyroid hormone receptor binding; transcription initiation from RNA polymerase II promoter; receptor activity; nucleus; transcription cofactor activity; transcription coactivator activity; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; nuclear hormone receptor binding; intracellular steroid hormone receptor signaling pathway; mediator complex;
SNW1	8	transcription initiation from RNA polymerase II promoter; nucleoplasm; regulation of transcription from RNA polymerase II promoter; nucleus; transcription coactivator activity; vitamin D receptor binding; nuclear hormone receptor binding; gene expression;
NCOA6	7	thyroid hormone receptor binding; transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; transcription coactivator activity; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding;
NCOR1	6	thyroid hormone receptor binding; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; gene expression;
TAF10	6	transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; transcription coactivator activity; gene expression;
MED23	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; gene expression; mediator complex;
MED7	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; gene expression; mediator complex;
SMARCD3	6	nucleoplasm; regulation of transcription from RNA polymerase II promoter; nucleus; transcription coactivator activity; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding;
NSD1	5	thyroid hormone receptor binding; nucleus; transcription cofactor activity; positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding;
POLR2G	5	transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; gene expression;
SUPT3H	5	transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; nucleus; transcription coactivator activity; positive regulation of transcription, DNA-dependent;
TAF13	5	transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; gene expression;
TAF4B	5	transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; gene expression;
TGFB1I1	5	transcription from RNA polymerase II promoter; transcription coactivator activity; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; nuclear hormone receptor binding;
MAML1	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; transcription coactivator activity; gene expression;
MAML2	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; transcription coactivator activity; gene expression;
MED15	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; gene expression; mediator complex;
NR5A1	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; transcription coactivator activity; gene expression;
YAP1	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleus; transcription coactivator activity; gene expression;
PRPF6	5	nucleoplasm; nucleus; transcription coactivator activity; nuclear hormone receptor binding; gene expression;
RAN	5	nucleoplasm; transcription coactivator activity; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; gene expression;
NRIP1	5	nucleus; transcription coactivator activity; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; nuclear hormone receptor binding;

Genes shared at least 2 KEGG pathways with MED16 (count: 0)

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Region: chr19:867962..893218 View in gBrowse