ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NUP62
Symbol Alias	p62, DKFZp547L134, IBSN, SNDI, MGC841, FLJ20822, FLJ43869
Approved Name	nucleoporin 62kDa
Previous Name	nucleoporin 62kD
Name Alias	nuclear pore glycoprotein p62
Location	19
Position	chr19:50410082-50432988, -
External Links	HGNC: 8066 Entrez Gene: 23636 Ensembl: ENSG00000213024 UCSC: uc002prb.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 41)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 40)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[15625236]	80
GO:0046578	regulation of Ras protein signal transduction	Biological Process	NAS[11553620]	3
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	Biological Process	NAS[11244088]	1
GO:0043130	ubiquitin binding	Molecular Function	IDA[8702753]	9
GO:0043231	intracellular membrane-bounded organelle	Cellular Component		62
GO:0043069	negative regulation of programmed cell death	Biological Process	IDA[11244088]	4
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IDA[10356400]	27
GO:0051028	mRNA transport	Biological Process		8
GO:0055085	transmembrane transport	Biological Process		82
GO:0046930	pore complex	Cellular Component	NAS[15175862]	1
GO:0046966	thyroid hormone receptor binding	Molecular Function	IPI[15625236]	18
GO:0017056	structural constituent of nuclear pore	Molecular Function		2
GO:0016032	viral reproduction	Biological Process		57
GO:0015758	glucose transport	Biological Process		13
GO:0015031	protein transport	Biological Process		75
GO:0010827	regulation of glucose transport	Biological Process		3
GO:0009966	regulation of signal transduction	Biological Process	NAS[8702753]	4
GO:0009755	hormone-mediated signaling pathway	Biological Process	NAS[15625236]	4
GO:0008645	hexose transport	Biological Process		6
GO:0043066	negative regulation of apoptotic process	Biological Process	IDA[11755531]	77
GO:0042169	SH2 domain binding	Molecular Function	IDA[8650207]	7
GO:0031965	nuclear membrane	Cellular Component		27
GO:0031074	nucleocytoplasmic shuttling complex	Cellular Component	NAS[8589458]	1
GO:0030529	ribonucleoprotein complex	Cellular Component	IDA[18809582]	23
GO:0030159	receptor signaling complex scaffold activity	Molecular Function	IDA[11244088]	8
GO:0019221	cytokine-mediated signaling pathway	Biological Process		28
GO:0000922	spindle pole	Cellular Component		22
GO:0003682	chromatin binding	Molecular Function	NAS[11852044]	48
GO:0005487	nucleocytoplasmic transporter activity	Molecular Function	NAS[8589458]	2
GO:0005515	protein binding	Molecular Function		910
GO:0005635	nuclear envelope	Cellular Component		19
GO:0005643	nuclear pore	Cellular Component	IDA[1915414]	9
GO:0005737	cytoplasm	Cellular Component	NAS[10373430]	690
GO:0005975	carbohydrate metabolic process	Biological Process		50
GO:0006351	transcription, DNA-dependent	Biological Process	IDA[10373430]	247
GO:0006913	nucleocytoplasmic transport	Biological Process	NAS[8589458]	2
GO:0007166	cell surface receptor signaling pathway	Biological Process	IDA[10799545]; NAS[10373430]	35
GO:0008219	cell death	Biological Process	IMP[11244088]	33
GO:0008285	negative regulation of cell proliferation	Biological Process	IDA[11013214]	59

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03013	RNA transport	15	RNA transport from the nucleus to the cytoplasm is fundamen...... RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation. More...

Genes shared at least 5 GO terms with NUP62 (count: 33)

Gene Symbol	Pathway Count	Pathway List
NUP155	12	small molecule metabolic process; transmembrane transport; structural constituent of nuclear pore; viral reproduction; glucose transport; regulation of glucose transport; hexose transport; nuclear membrane; cytokine-mediated signaling pathway; nuclear envelope; nuclear pore; carbohydrate metabolic process;
NUPL2	11	small molecule metabolic process; mRNA transport; transmembrane transport; viral reproduction; glucose transport; regulation of glucose transport; hexose transport; nuclear membrane; cytokine-mediated signaling pathway; nuclear pore; carbohydrate metabolic process;
MED1	7	positive regulation of transcription, DNA-dependent; small molecule metabolic process; thyroid hormone receptor binding; negative regulation of apoptotic process; nuclear hormone receptor binding; chromatin binding; protein binding;
NCOA6	7	positive regulation of transcription, DNA-dependent; small molecule metabolic process; intracellular membrane-bounded organelle; thyroid hormone receptor binding; nuclear hormone receptor binding; chromatin binding; protein binding;
RELA	7	positive regulation of transcription, DNA-dependent; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of apoptotic process; cytokine-mediated signaling pathway; chromatin binding; protein binding; cytoplasm;
TFAP2A	7	positive regulation of transcription, DNA-dependent; intracellular membrane-bounded organelle; negative regulation of apoptotic process; chromatin binding; protein binding; cytoplasm; negative regulation of cell proliferation;
XPO1	7	mRNA transport; viral reproduction; ribonucleoprotein complex; protein binding; nuclear envelope; nuclear pore; cytoplasm;
HMGA1	6	positive regulation of transcription, DNA-dependent; viral reproduction; nuclear hormone receptor binding; protein binding; transcription, DNA-dependent; negative regulation of cell proliferation;
MMS19	6	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; receptor signaling complex scaffold activity; protein binding; cytoplasm; transcription, DNA-dependent;
RAN	6	positive regulation of transcription, DNA-dependent; viral reproduction; chromatin binding; protein binding; nuclear pore; cytoplasm;
SMARCD3	6	positive regulation of transcription, DNA-dependent; small molecule metabolic process; nuclear hormone receptor binding; protein binding; cytoplasm; transcription, DNA-dependent;
HK1	6	small molecule metabolic process; transmembrane transport; glucose transport; hexose transport; protein binding; carbohydrate metabolic process;
NCOR1	6	small molecule metabolic process; thyroid hormone receptor binding; chromatin binding; protein binding; cytoplasm; transcription, DNA-dependent;
MVP	6	mRNA transport; protein transport; ribonucleoprotein complex; protein binding; nuclear pore; cytoplasm;
APBB1	5	positive regulation of transcription, DNA-dependent; chromatin binding; protein binding; cytoplasm; transcription, DNA-dependent;
NSD1	5	positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; nuclear hormone receptor binding; chromatin binding; transcription, DNA-dependent;
TGFB1I1	5	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; protein binding; cytoplasm; negative regulation of cell proliferation;
THRAP3	5	positive regulation of transcription, DNA-dependent; intracellular membrane-bounded organelle; thyroid hormone receptor binding; nuclear hormone receptor binding; protein binding;
INPPL1	5	small molecule metabolic process; SH2 domain binding; protein binding; cytoplasm; negative regulation of cell proliferation;
SLC2A3	5	small molecule metabolic process; transmembrane transport; glucose transport; hexose transport; carbohydrate metabolic process;
SLC37A4	5	small molecule metabolic process; transmembrane transport; glucose transport; hexose transport; carbohydrate metabolic process;
ATXN1	5	intracellular membrane-bounded organelle; protein binding; cytoplasm; transcription, DNA-dependent; cell death;
KANK2	5	negative regulation of programmed cell death; protein binding; cytoplasm; transcription, DNA-dependent; negative regulation of cell proliferation;
BIRC2	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of apoptotic process; protein binding; transcription, DNA-dependent; cell surface receptor signaling pathway;
BIRC3	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of apoptotic process; protein binding; cytoplasm; cell surface receptor signaling pathway;
PRKCB	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; chromatin binding; protein binding; cytoplasm; transcription, DNA-dependent;
UBB	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; cytokine-mediated signaling pathway; protein binding; transcription, DNA-dependent;
UBC	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; cytokine-mediated signaling pathway; protein binding; transcription, DNA-dependent;
RCC1	5	viral reproduction; nuclear membrane; chromatin binding; protein binding; cytoplasm;
XRCC5	5	viral reproduction; negative regulation of apoptotic process; protein binding; cytoplasm; transcription, DNA-dependent;
BNIP3	5	negative regulation of apoptotic process; protein binding; nuclear envelope; cytoplasm; cell death;
IGHMBP2	5	ribonucleoprotein complex; protein binding; cytoplasm; transcription, DNA-dependent; cell death;
MEN1	5	chromatin binding; protein binding; cytoplasm; transcription, DNA-dependent; negative regulation of cell proliferation;

Genes shared at least 2 KEGG pathways with NUP62 (count: 0)

View in gBrowse

Region: chr19:50410082..50432988 View in gBrowse