ADHDgene Database

Gene Report

Basic Info

Approved Symbol	KANK2
Previous Symbol	MXRA3, ANKRD25
Symbol Alias	KIAA1518
Approved Name	KN motif and ankyrin repeat domains 2
Previous Name	matrix-remodelling associated 3, "ankyrin repeat domain 25"
Location	19p13.2
Position	chr19:11274943-11308243, -
External Links	HGNC: 29300 Entrez Gene: 25959 Ensembl: ENSG00000197256 UCSC: uc002mqo.3
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hinney, A., 2011	This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08.	Non-significant

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs4804149	Chr19:11284028(Fwd)	intron_variant; upstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0005739	mitochondrion	Cellular Component		183
GO:0008285	negative regulation of cell proliferation	Biological Process	IDA[17476305]	59
GO:0006915	apoptotic process	Biological Process		111
GO:0043069	negative regulation of programmed cell death	Biological Process		4
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	Biological Process	IDA[17476305]	4
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	Biological Process	IDA[17476305]	2
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[17476305]	78
GO:0005737	cytoplasm	Cellular Component	IDA[17476305]	690
GO:0005515	protein binding	Molecular Function		910

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with KANK2 (count: 4)

Gene Symbol	Pathway Count	Pathway List
MAPK1	5	transcription, DNA-dependent; mitochondrion; apoptotic process; cytoplasm; protein binding;
MEN1	5	transcription, DNA-dependent; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding;
NUP62	5	transcription, DNA-dependent; negative regulation of cell proliferation; negative regulation of programmed cell death; cytoplasm; protein binding;
TCF25	5	transcription, DNA-dependent; mitochondrion; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding;

Genes shared at least 2 KEGG pathways with KANK2 (count: 0)

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Region: chr19:11274943..11308243 View in gBrowse