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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Study Report

Basic Info

Reference	Hinney, A., 201122012869
Citation	Hinney A., Scherag A., Jarick I., Albayrak O., Putter C., Pechlivanis S., Dauvermann M. R., Beck S., Weber H., Scherag S., Nguyen T. T., Volckmar A. L., Knoll N., Faraone S. V., Neale B. M., Franke B., Cichon S., Hoffmann P., Nothen M. M., Schreiber S., Jockel K. H., Wichmann H. E., Freitag C., Lempp T., Meyer J., Gilsbach S., Herpertz-Dahlmann B., Sinzig J., Lehmkuhl G., Renner T. J., Warnke A., Romanos M., Lesch K. P., Reif A., Schimmelmann B. G. and Hebebrand J. (2011) "Genome-wide association study in German patients with attention deficit/hyperactivity disorder." Am J Med Genet B Neuropsychiatr Genet, 156B(8): 888-97.
Study Design	case-control and family-based
Study Type	GWAS
Sample Size	495 cases and 1300 controls for GWAS approach
Predominant Ethnicity	Caucasian
Population	German
Gender	400 male and 95 female patients
Age Group	Children/Adolescents : age range 6-18 years; mean age=11, SD=2.7 years of patients

Detail Info

Summary	The heritability of attention deficit hyperactivity disorder (ADHD) is approximately 0.8. Despite several larger scale attempts, genome-wide association studies (GWAS) have not led to the identification of significant results. We performed a GWAS based on 495 German young patients with ADHD (according to DSM-IV criteria; Human660W-Quadv1; Illumina, San Diego, CA) and on 1,300 population-based adult controls (HumanHap550v3; Illumina). None of the combined analyses revealed a genome-wide significant result. SNPs in previously described autosomal candidate genes did not show significantly lower P-values compared to SNPs within random sets of genes of the same size. We did not find genome-wide significant results in a GWAS of German children with ADHD compared to controls. The second best SNP is located in an intron of GRM5, a gene located within a recently described region with an infrequent copy number variation in patients with ADHD.
Total Sample	Four hundred ninety-five German young patients with ADHD were recruited; One thousand three hundred adult controls were drawn from three populationbased epidemiological studies; The 'Wurzburg sample' consisted of 149 families (510 individuals) The 'Frankfurt/Homburg/Trier sample' consisted of 171 trios (513 individuals).
Replication Size	320 families for replication
Sample Collection	Four hundred ninety-five German young patients with ADHD were recruited and phenotypically characterized in six psychiatric outpatient units for children and adolescents (Aachen, Cologne, Essen, Marburg, Regensburg, and Wurzburg). One thousand three hundred adult controls were drawn from three population-based epidemiological studies: (a) the Heinz Nixdorf Recall study, (b) PopGen, (c) KORA. The recruitment areas were Essen, Bochum, and Mulheim (Ruhr area) for (a), Schleswig-Holstein (Northern Germany) for (b), and Augsburg (Southern Germany) for (c), respectively. Replication: All children were recruited from outpatient clinics at the Departments of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy of the Universities ofW€urzburg, Frankfurt, and Homburg and the local child psychiatry clinic in Trier.
Diagnosis Description	Patients were included if they were diagnosed with ADHD according to DSM-IV. GWAS approach: Combined type 362 (73.1%); Predominantly inattentive type 108 (21.8%); Predominantly hyperactive-impulsive type 25 (5.1%). Replication: ADHD (DSM-IV criteria)
Technique	The genome-wide genotyping was performed on HumanHap550v3 (Illumina; controls) and Human660W-Quadv1 BeadArrays (Illumina; cases). We applied a quality control (QC) protocol to filter genotypes and individuals to the overlapping genotype content of all GWAS data sets. After QC we validated the three (rs4862110, rs2556378, and rs5016282) initially best GWAS SNPs (according to P-value) by genotyping the GWAS cases by independent genotyping methods; The 30 best, independent SNPs which passed the QC filter were genotyped in the independent 'Wurzburg sample'. SNP genotyping of 28 of these SNPs was performed using Sequenom's MassArray system (Sequenom, San Diego, CA) according to the instructions supplied by the manufacturer.
Analysis Method	Using PLINK v1.07 we applied Cochran-Armitage Trend tests to assess all autosomal SNPs for association with the disorder as recommended while X chromosomal SNPs were tested by the allelic test which basically weights X alleles of women and men equally. We used the family-based association test (FBAT) for the association analysis to address the impact of one or more offspring affected with ADHD for each family. We also report the findings from the meta-analyses of both the GWAS and the replication data sets applying Fisher's combined probability test which weights each data set equally. For 64 previously described autosomal ADHD candidate genes we performed a gene-set enrichment analysis (GSEA) by testing in the style of the Meta-Analysis Gene-set Enrichment of variaNT Associations (MAGENTA) algorithm; For a total of 17,680 unique autosomal genes, PLINK v1.07 was used to calculate gene-wise empirical P-values based on 1,000,000 permutations of the trait status.
Result Description	Some genes neighboring the single nucleotide polymorphisms (SNPs) with the lowest P-values (best P-value: 8.38 x 10(-7)) have potential relevance for ADHD (e.g., glutamate receptor, metabotropic 5 gene, GRM5). After quality control, the 30 independent SNPs with the lowest P-values (P-values

SNPs reported by this study (count: 30)

SNP	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
rs7105122	C	GWAS P-value=9.10E-06, OR=1.47, Replication FBAT P-value=0.5279, Combination P-value=1.76E-05	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend
rs9844608	A	GWAS P-value=9.31E-06, OR=1.45, Replication FBAT P-value=0.5347, Combination P-value=1.82E-05	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend
rs11757000	T	GWAS P-value=1.17E-05, OR=1.72, Replication FBAT P-value=0.9177, Combination P-value=7.63E-05	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs4804149	C	GWAS P-value=1.20E-05, OR=1.42, Replication FBAT P-value=0.1096, Combination P-value=7.81E-05	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs6458351	T	GWAS P-value=1.39E-05, OR=1.72, Replication FBAT P-value=0.1967, Combination P-value=8.95E-05	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs7984422	A	GWAS P-value=1.42E-05, OR=2.41, Replication FBAT P-value=0.0896, Combination P-value=5.08E-06	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend
rs1430961	C	GWAS P-value=1.49E-05, OR=1.76, Replication FBAT P-value=0.6698, Combination P-value=3.47E-05	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs17031719	G	GWAS P-value=1.62E-05, OR=1.53, Replication FBAT P-value=0.2489, Combination P-value=1.03E-04	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs2556378	T	GWAS P-value=8.08E-07, OR=1.61, Replication FBAT P-value=0.4751, Combination P-value=1.70E-06	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend
rs5016282	A	GWAS P-value=1.78E-06, OR=1.85, Replication FBAT P-value=0.3428, Combination P-value=2.55E-06	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend
rs2532274	C	GWAS P-value=5.82E-06, OR=1.49, Replication FBAT P-value=0.1585, Combination P-value=3.76E-06	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend
rs7694947	T	GWAS P-value=4.22E-05, OR=1.36, Replication FBAT P-value=0.5637, Combination P-value=2.48E-04	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs655824	C	GWAS P-value=3.98E-05, OR=1.85, Replication FBAT P-value=0.6473, Combination P-value=8.34E-05	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs2773822	C	GWAS P-value=5.04E-05, OR=1.66, Replication FBAT P-value=0.7357, Combination P-value=1.17E-04	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs6732434	A	GWAS P-value=4.68E-05, OR=1.41, Replication FBAT P-value=0.0042, Combination P-value=2.73E-04	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs13270024	C	GWAS P-value=5.75E-05, OR=1.46	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs9929758	T	GWAS P-value=5.47E-05, OR=1.57, Replication FBAT P-value=0.5485, Combination P-value=9.60E-05	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs2580817	A	GWAS P-value=6.15E-05, OR=1.54, Replication FBAT P-value=0.2763, Combination P-value=3.50E-04	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs1859063	G	GWAS P-value=5.83E-05, OR=2.35, Replication FBAT P-value=0.3173, Combination P-value=3.34E-04	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs11142062	T	GWAS P-value=2.05E-05, OR=1.59, Replication FBAT P-value=0.9013, Combination P-value=6.14E-05	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs13119057	T	GWAS P-value=1.86E-05, OR=1.43, Replication FBAT P-value=0.0265, Combination P-value=1.17E-04	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs10838881	T	GWAS P-value=2.24E-05, OR=1.66, Replication FBAT P-value=0.1083, Combination P-value=9.29E-06	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend
rs3760201	T	GWAS P-value=2.05E-05, OR=1.44, Replication FBAT P-value=0.2466, Combination P-value=1.84E-05	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs2509689	C	GWAS P-value=2.84E-05, OR=1.52, Replication FBAT P-value=0.0499, Combination P-value=5.62E-06	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend
rs2114961	T	GWAS P-value=2.70E-05, OR=1.46, Replication FBAT P-value=1, Combination P-value=1.65E-04	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs3741410	A	GWAS P-value=3.84E-05, OR=1.62, Replication FBAT P-value=0.0792, Combination P-value=1.15E-05	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs4549394	T	GWAS P-value=3.58E-05, OR=1.52, Replication FBAT P-value=0.425, Combination P-value=5.13E-05	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs1623319	A	GWAS P-value=7.57E-05, OR=1.38, Replication FBAT P-value=0.4862, Combination P-value=1.16E-04	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs10515549	G	GWAS P-value=6.55E-05, OR=1.34, Replication FBAT P-value=0.8175, Combination P-value=1.64E-04	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
rs650957	T	GWAS P-value=7.38E-05, OR=1.33, Replication FBAT P-value=0.5858, Combination P-value=1.34E-04	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant

Genes reported by this study (count: 30)

Gene	Statistical Values/Author Comments	Result of Statistical Analysis
GRM5	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend
KANK2	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
KIAA1267	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend
GRIK4	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
SSFA2	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
COX7B2	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
MYBPC1	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
H2AFY	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
SNCA	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
MMP7	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend
MAP2K3	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
GFI1B	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
CDK20	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
CLASP2	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend
GPX6	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
GPR125	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
GPC5	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend
PHLDA1	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
PRELID2	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
DENND3	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
PGRMC2	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
RGS18	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
PSMC3	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend
PTPRJ	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
OR4C3	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend
ATP2C2	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
VEGFA	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
NPPC	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant
BCL11A	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Trend
LOC151121	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant