ADHDgene Database

Gene Report

Basic Info

Approved Symbol	GPC5
Approved Name	glypican 5
Name Alias	glypican proteoglycan 5
Location	13q32
Position	chr13:92050929-93519490, +
External Links	HGNC: 4453 Entrez Gene: 2262 Ensembl: ENSG00000179399 UCSC: uc010tif.1
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hinney, A., 2011	This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08.	Trend

Gene related SNPs (count: 10)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs7984422	Chr13:92808689(Fwd)	intron_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005578	proteinaceous extracellular matrix	Cellular Component		47
GO:0005615	extracellular space	Cellular Component		126
GO:0005796	Golgi lumen	Cellular Component		12
GO:0005886	plasma membrane	Cellular Component		772
GO:0030203	glycosaminoglycan metabolic process	Biological Process		20
GO:0030204	chondroitin sulfate metabolic process	Biological Process		7
GO:0031225	anchored to membrane	Cellular Component		29
GO:0043202	lysosomal lumen	Cellular Component		10
GO:0005887	integral to plasma membrane	Cellular Component	TAS[7657705]	220
GO:0005975	carbohydrate metabolic process	Biological Process		50
GO:0006024	glycosaminoglycan biosynthetic process	Biological Process		7
GO:0006027	glycosaminoglycan catabolic process	Biological Process		3
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0043395	heparan sulfate proteoglycan binding	Molecular Function		3

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with GPC5 (count: 6)

Gene Symbol	Pathway Count	Pathway List
GPC6	14	proteinaceous extracellular matrix; extracellular space; Golgi lumen; plasma membrane; glycosaminoglycan metabolic process; chondroitin sulfate metabolic process; anchored to membrane; lysosomal lumen; integral to plasma membrane; carbohydrate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; small molecule metabolic process; heparan sulfate proteoglycan binding;
OGN	7	proteinaceous extracellular matrix; extracellular space; Golgi lumen; glycosaminoglycan metabolic process; lysosomal lumen; carbohydrate metabolic process; small molecule metabolic process;
OMD	6	proteinaceous extracellular matrix; Golgi lumen; glycosaminoglycan metabolic process; lysosomal lumen; carbohydrate metabolic process; small molecule metabolic process;
HAS3	5	plasma membrane; glycosaminoglycan metabolic process; integral to plasma membrane; carbohydrate metabolic process; small molecule metabolic process;
STAB2	5	plasma membrane; glycosaminoglycan metabolic process; integral to plasma membrane; carbohydrate metabolic process; small molecule metabolic process;
B3GAT3	5	glycosaminoglycan metabolic process; chondroitin sulfate metabolic process; carbohydrate metabolic process; glycosaminoglycan biosynthetic process; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with GPC5 (count: 0)

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Region: chr13:92050929..93519490 View in gBrowse