ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GRIK4
Previous Symbol	GRIK
Symbol Alias	GluK4, KA1
Approved Name	glutamate receptor, ionotropic, kainate 4
Location	11q23.3
Position	chr11:120382468-120859613, 1
External Links	HGNC: 4582 Entrez Gene: 2900 Ensembl: ENSG00000149403 UCSC: uc009zax.1
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by Literature SNP; Mapped by significant region

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hinney, A., 2011	This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08.	Non-significant

Gene related SNPs (count: 31)

Literature-origin SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs10892592	chr11:120522003(Fwd)	intron_variant; nc_transcript_variant	1(0/1/0)
rs655824	chr11:120834480(Fwd)	downstream_gene_variant; intron_variant	1(0/1/0)
rs4935750	chr11:120521066(Fwd)	intron_variant; nc_transcript_variant	1(0/1/0)
rs4245040	chr11:120520629(Fwd)	intron_variant; nc_transcript_variant	1(0/1/0)
rs4936537	chr11:120526365(Fwd)	intron_variant; nc_transcript_variant	1(0/1/0)
rs4570590	chr11:120523139(Fwd)	intron_variant; nc_transcript_variant	1(0/1/0)

LD-proxies (count: 25)

rs_ID	Location	Functional Annotation
rs11218091	chr11:120848006(Fwd)	intron_variant
rs524792	chr11:120830413(Fwd)	intron_variant; nc_transcript_variant
rs10750178	chr11:120823528(Fwd)	intron_variant; nc_transcript_variant
rs11217941	chr11:120531656(Fwd)	intron_variant; nc_transcript_variant
rs582718	chr11:120823104(Fwd)	intron_variant; nc_transcript_variant
rs6589829	chr11:120530973(Fwd)	intron_variant; nc_transcript_variant; splice_region_variant
rs684913	chr11:120819562(Fwd)	intron_variant; nc_transcript_variant
rs471403	chr11:120816277(Fwd)	intron_variant; nc_transcript_variant
rs609989	chr11:120814342(Fwd)	intron_variant; nc_transcript_variant
rs511939	chr11:120813715(Fwd)	intron_variant; nc_transcript_variant
rs580711	chr11:120809198(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs509566	chr11:120801460(Fwd)	intron_variant; nc_transcript_variant
rs2850807	chr11:120797893(Fwd)	intron_variant; nc_transcript_variant
rs2852241	chr11:120797584(Fwd)	intron_variant; nc_transcript_variant
rs10892591	chr11:120521766(Fwd)	intron_variant; nc_transcript_variant
rs1893907	chr11:120524884(Fwd)	intron_variant; nc_transcript_variant
rs4935749	chr11:120518929(Fwd)	intron_variant; nc_transcript_variant
rs4936536	chr11:120521485(Fwd)	intron_variant; nc_transcript_variant
rs6589826	chr11:120517643(Fwd)	intron_variant; nc_transcript_variant
rs6589827	chr11:120517844(Fwd)	intron_variant; nc_transcript_variant
rs1317514	chr11:120513914(Fwd)	intron_variant; nc_transcript_variant
rs2000874	chr11:120516717(Fwd)	intron_variant; nc_transcript_variant
rs7939968	chr11:120531435(Fwd)	intron_variant; nc_transcript_variant
rs1893906	chr11:120525032(Fwd)	intron_variant; nc_transcript_variant
rs4936538	chr11:120530316(Fwd)	intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005886	plasma membrane	cellular component	TAS	839
GO:0030054	cell junction	cellular component	IEA	84
GO:0007215	glutamate receptor signaling pathway	biological process	TAS[8263508]	6
GO:0045211	postsynaptic membrane	cellular component	IEA	45
GO:0005234	extracellular-glutamate-gated ion channel activity	molecular function	IEA	8
GO:0007268	synaptic transmission	biological process	TAS	103
GO:0042734	presynaptic membrane	cellular component	IEA	16
GO:0006810	transport	biological process	TAS[8263508]	67
GO:0005887	integral to plasma membrane	cellular component	TAS[8263508]	236
GO:0032983	kainate selective glutamate receptor complex	cellular component	IEA	3
GO:0015277	kainate selective glutamate receptor activity	molecular function	TAS[8263508]	3

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	89

Genes shared at least 5 GO terms with GRIK4 (count: 14)

Gene Symbol	Pathway Count	Pathway List
GRIK1	11	plasma membrane; cell junction; glutamate receptor signaling pathway; postsynaptic membrane; extracellular-glutamate-gated ion channel activity; synaptic transmission; presynaptic membrane; transport; integral to plasma membrane; kainate selective glutamate receptor complex; kainate selective glutamate receptor activity;
GRIN2A	9	plasma membrane; cell junction; glutamate receptor signaling pathway; postsynaptic membrane; extracellular-glutamate-gated ion channel activity; synaptic transmission; presynaptic membrane; transport; integral to plasma membrane;
GRIA4	9	plasma membrane; cell junction; glutamate receptor signaling pathway; postsynaptic membrane; extracellular-glutamate-gated ion channel activity; synaptic transmission; transport; kainate selective glutamate receptor complex; kainate selective glutamate receptor activity;
GRIN2B	8	plasma membrane; cell junction; glutamate receptor signaling pathway; postsynaptic membrane; extracellular-glutamate-gated ion channel activity; synaptic transmission; transport; integral to plasma membrane;
GRID2	7	plasma membrane; cell junction; glutamate receptor signaling pathway; postsynaptic membrane; extracellular-glutamate-gated ion channel activity; transport; integral to plasma membrane;
GABRB3	6	plasma membrane; cell junction; postsynaptic membrane; synaptic transmission; transport; integral to plasma membrane;
GABRA5	6	plasma membrane; cell junction; postsynaptic membrane; synaptic transmission; transport; integral to plasma membrane;
HTR3A	6	plasma membrane; cell junction; postsynaptic membrane; synaptic transmission; transport; integral to plasma membrane;
CHRNB4	5	plasma membrane; cell junction; postsynaptic membrane; synaptic transmission; integral to plasma membrane;
HTR3B	5	plasma membrane; postsynaptic membrane; synaptic transmission; transport; integral to plasma membrane;
GABBR2	5	plasma membrane; cell junction; postsynaptic membrane; synaptic transmission; integral to plasma membrane;
CHRNA5	5	plasma membrane; cell junction; postsynaptic membrane; synaptic transmission; transport;
ACHE	5	plasma membrane; cell junction; postsynaptic membrane; synaptic transmission; presynaptic membrane;
GRM7	5	plasma membrane; postsynaptic membrane; synaptic transmission; presynaptic membrane; integral to plasma membrane;

Genes shared at least 2 KEGG pathways with GRIK4 (count: 0)

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Region: chr11:120382468..120859613 View in gBrowse