ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HTR3B
Symbol Alias	5-HT3B
Approved Name	5-hydroxytryptamine (serotonin) receptor 3B
Location	11q23.1
Position	chr11:113775519-113817283, +
External Links	HGNC: 5298 Entrez Gene: 9177 Ensembl: ENSG00000149305 UCSC: uc001pok.2
No. of Studies	3 (significant: 1; non-significant: 2; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region

Gene related studies (count: 3)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Ribases M, 2009(b)	little evidence of association with ADHD was found.	Non-significant
Brookes K, 2006	UNPHASED TDT P-value=0.121, global P-value=0.778, WHAP TDT P_sum P-value=0.81, no SNP with nominal P-value<0.05 located in this gene	Non-significant
Oades RD, 2008	2 SNPs showed significant association	Significant

Gene related SNPs (count: 6)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs3782025	Chr11:113807607(Fwd)	intron_variant	1(1/0/0)
rs1672717	Chr11:113812733(Fwd)	intron_variant	2(2/0/0)

LD-proxies (count: 4)

rs_ID	Location	Functional Annotation
rs1185027	Chr11:113817656(Fwd)	downstream_gene_variant
rs1176746	Chr11:113802601(Fwd)	intron_variant
rs11214782	Chr11:113821793(Fwd)	downstream_gene_variant
rs7129190	Chr11:113818752(Fwd)	downstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004993	serotonin receptor activity	Molecular Function		13
GO:0005232	serotonin-activated cation-selective channel activity	Molecular Function		2
GO:0005216	ion channel activity	Molecular Function	TAS[9950429]	6
GO:0055085	transmembrane transport	Biological Process		82
GO:0034220	ion transmembrane transport	Biological Process		11
GO:0045211	postsynaptic membrane	Cellular Component		41
GO:0006810	transport	Biological Process	TAS[9950429]	62
GO:0007268	synaptic transmission	Biological Process	TAS[9950429]	96
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component		220

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with HTR3B (count: 12)

Gene Symbol	Pathway Count	Pathway List
HTR3A	9	serotonin receptor activity; serotonin-activated cation-selective channel activity; transmembrane transport; ion transmembrane transport; postsynaptic membrane; transport; synaptic transmission; plasma membrane; integral to plasma membrane;
GABRA5	7	transmembrane transport; ion transmembrane transport; postsynaptic membrane; transport; synaptic transmission; plasma membrane; integral to plasma membrane;
GABRB3	7	transmembrane transport; ion transmembrane transport; postsynaptic membrane; transport; synaptic transmission; plasma membrane; integral to plasma membrane;
FXYD2	5	ion channel activity; transmembrane transport; ion transmembrane transport; transport; plasma membrane;
GABRG3	5	transmembrane transport; ion transmembrane transport; postsynaptic membrane; synaptic transmission; plasma membrane;
SLC6A1	5	transmembrane transport; transport; synaptic transmission; plasma membrane; integral to plasma membrane;
SLC6A2	5	transmembrane transport; transport; synaptic transmission; plasma membrane; integral to plasma membrane;
SLC6A3	5	transmembrane transport; transport; synaptic transmission; plasma membrane; integral to plasma membrane;
GRIK1	5	postsynaptic membrane; transport; synaptic transmission; plasma membrane; integral to plasma membrane;
GRIK4	5	postsynaptic membrane; transport; synaptic transmission; plasma membrane; integral to plasma membrane;
GRIN2A	5	postsynaptic membrane; transport; synaptic transmission; plasma membrane; integral to plasma membrane;
GRIN2B	5	postsynaptic membrane; transport; synaptic transmission; plasma membrane; integral to plasma membrane;

Genes shared at least 2 KEGG pathways with HTR3B (count: 0)

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Region: chr11:113775519..113817283 View in gBrowse